Crystallography matters!

International Year of Crystallography 2014

Crystallography matters!
Published by the United Nations Educational,
Scientific and Cultural Organization
7, place de Fontenoy, 75352 Paris 07 SP, France
UNESCO 2013
All rights reserved
Original title: Crystallography matters!
Coordinator/Editor: Susan Schneegans
Front cover photos : Aeroplane Shutterstock/IM_photo; Scientist in Africa @ FAO
Back cover photo: Young family watching TV @ Shutterstock/Andrey_Popov
Composed and printed
in the workshops of UNESCO
The printer is certified ImprimVert,
the French printing industrys environmental initiative.
Printed in France
SC-2013/WS/9
CLD 1251.13

What is crystallography?
Crystals can be found everywhere in nature. They are particularly abundant in rock
formations as minerals (gemstones, graphite, etc.) but can also be found elsewhere,
examples being snowflakes, ice and grains of salt. Since ancient times, scholars have
been intrigued by the beauty of crystals, their symmetrical shape and variety of
colours. These early crystallographers used geometry to study the shape of crystals in
the natural world.
In the early 20th century, it was realized that X-rays could be used to see the
structure of matter in a non-intrusive manner. This marks the dawn of modern
crystallography. X-rays had been discovered in 1895. They are beams of light that
are not visible to the human eye. When X-rays hit an object, the objects atoms
scatter the beams. Crystallographers discovered that crystals, because of their
regular arrangement of atoms, scattered the rays in just a few specific directions.
Bymeasuring these directions and the intensity of the scattered beams, scientists
were able to produce a three-dimensional picture of the crystals atomic structure.
Crystals were found to be ideal subjects for studying the structure of matter at the
atomic or molecular level, on account of three common characteristics: they are
solids, three-dimensional and built from very regular and often highly symmetrical
arrangements ofatoms.
Thanks to X-ray crystallography, scientists can study the chemical bonds which draw
one atom to another. Take graphite and diamonds, for instance. These minerals
hardly look alike: one is opaque and soft (graphite is used to make pencils), whereas
the other is transparent and hard. Yet graphite and diamonds are close relatives,
chemically speaking, both being composed of carbon. It is the ability to disperse light
owing to the structure of its chemical bonds which gives a diamond its shine.
Weknow this thanks to X-ray crystallography.

Snowflakes are crystals. Their

hexagonal symmetry results from the
way in which water molecules are
bound to each other.
Image: Wikipedia

At first, X-ray crystallography could only be used to look at solid crystals with a
regular arrangement of atoms. It could study minerals, for instance, and many other
compounds, such as salt or sugar. It could also study ice but only until it melted.

The crystal structure of graphite

(left) is very different from that
ofdiamond. IUCr

Crystallography matters!

A chunk of graphite
(left) and a rough
diamond (right).
These two crystals
may not look alike
but they are actually
closely related,
as both are pure
carbon. What gives
the diamond its
shine is its ability to
disperse light, owing
to the structure of its
chemical bonds.
Photos: Wikipedia

Crystallography matters!

2
This is because, in a liquid, the movement
of molecules made it impossible to register
a scattered signal that could be interpreted.
Crystallographers discovered that they could
study biological materials, such as proteins
or DNA, by making crystals of them. This
extended the scope of crystallography to
biology and medicine. The discovery came at
a time when the growing power of computers
was making it possible to model the structure
of these more complex crystals.

3D image of a crystal structure. In

a crystal, atoms, groups of atoms,
ions or molecules have a regular
arrangement in three dimensions.
IUCr

After 100 years of development, X-ray

crystallography has become the leading
technique for studying the atomic structure
and related properties of materials. It is now at
the centre of advances in many fields of science. New crystallographic methods are
still being introduced and new sources (electrons, neutrons and synchrotron light)
have become available. These developments enable crystallographers to study the
atomic structure of objects that are not perfect crystals, including quasicrystals (see
box) and liquid crystals (see photo of television overleaf).
The development of machines capable of generating intense light and X-rays
(synchrotrons) has revolutionized crystallography. Large research facilities housing
synchrotrons are used by crystallographers working in areas such as biology, chemistry,
materials science, physics, archaeology and geology. Synchrotrons enable archaeologists
to pinpoint the composition and age of artefacts dating back tens of thousands of years,
for instance, and geologists to analyse and date meteorites and lunar rocks.

QUASICRYSTALS: DEFYING THE LAWS OF NATURE

In 1984, Dan Shechtman discovered the existence of a crystal in which the atoms were assembled in a model that could not be
strictly repeated. This defied the accepted wisdom about the symmetry of crystals. Up until then, it had been thought that only
symmetrical geometric forms with 1, 2, 3, 4 or 6 sides could occur as crystals, since only these forms could be reproduced in three
dimensions.
Yet, when Dan Shechtman
observed an alloy of aluminium
and manganese under an electron
microscope, he discovered a
pentagon (five-sided shape). This
outlaw came to be known as a
quasicrystal. Dan Shechtmans
groundbreaking discovery would
earn him the Nobel Prize in
Chemistry in 2011.
As a consequence of the way in
which their atoms are arranged,
quasicrystals have unusual
properties: they are hard and brittle
and behave almost like glass, being
resistant to corrosion and adhesion.
They are now used in a number of
industrial applications, one example
being non-stick pans.

Source: diffraction pattern image, Physical Review Letters (1984), vol. 53, pages 19511953;
image from the mosaic, Moroccan Crystallographic Association

Moroccan artisans (Maalems) have actually known about the patterns found in quasicrystals for centuries. Seven hundred
years separate the two images above. The image on the left shows the diffraction pattern of a quasicrystal obtained by Dan
Shechtman in 1984. The photo on the right shows a fine mosaic (zellije) in the Attaraine Madrasa in Fez (Morocco), dating from the
14thcentury. The images look remarkably similar, with both showing pentagonal patterns.

A brief history
Throughout history, people have been fascinated by the beauty and mystery
of crystals. Two thousand years ago, Roman naturalist Pliny the Elder admired
the regularity of the six-sided prisms of rock crystals. At the time, the process of
crystallizing sugar and salt was already known to the ancient Indian and Chinese
civilizations: cane sugar crystals were manufactured from sugar cane juice in
India and, in China, brine was boiled down into pure salt. Crystallization was also
developed in Iraq in the 8th century CE. Two hundred years later, Egypt and the
region of Andalucia in Spain would master the technique of cutting rock crystals
for use in utensils and decorative items like the box pictured here. In 1611, German
mathematician and astronomer Johannes Kepler was the first to observe the
symmetrical shape of snowflakes and infer from this their underlying structure.
Less than 200 years later, French mineralogist Ren Just Hay would discover the
geometrical law of crystallization.

Gem-studded box made in Egypt in

about 1200 CE
Muse de Cluny, France

In 1895, X-rays were discovered by William Conrad Rntgen, who was awarded the
first Nobel Prize in Physics in 1901. It was Max von Laue and his co-workers, however,
who would discover that X-rays travelling through a crystal interacted with it and, as a
result, were diffracted in particular directions, depending on the nature of the crystal.
This discovery earned von Laue the Nobel Prize in Physics in 1914.

Between the 1920s and the 1960s, X-ray crystallography helped to reveal some
of the mysteries of the structure of life, with great ramifications for health care.
DorothyHodgkin solved the structures of a number of biological molecules, including
cholesterol (1937), penicillin (1946), vitamin B12 (1956) and insulin (1969). She was
awarded the Nobel Prize in Chemistry in 1964. Sir John Kendrew and MaxPerutz were
the first to work out the crystal structure of a protein, earning them the NobelPrize
in Chemistry in 1962. Since that breakthrough, the crystal structure of over
90,000proteins, nucleic acids and other biological molecules has been determined
using X-ray crystallography.
One of the biggest milestones of the 20th century was the discovery of the crystal
structure of DNA by James Watson and Francis Crick. Perhaps less well known is the
fact that their discovery was made on the basis of diffraction experiments carried
out by Rosalind Franklin, who died prematurely in 1958. The discovery of the double
helix paved the way to macromolecule and protein crystallography, essential tools of
the biological and medical sciences today. Watson and Crick were rewarded with the
Nobel Prize in Physiology or Medicine in 1962, together with Maurice Wilkins, who
had worked with Rosalind Franklin.
Crystallography and crystallographic methods have continued to develop over the
last 50years; in 1985, for example, the Nobel Prize in Chemistry was awarded to Herb
Hauptman and Jerome Karle for developing new methods of analysing crystal structures.
As a result, the crystal structures of more and more compounds have been solved.
Recent Nobel Prizes have been awarded to Venkatraman Ramakrishnan, Thomas
Steitz and Ada Yonath (2009, see page 8), to Andre Geim and Konstantin Novoselov
(2010) for their groundbreaking work on graphene, the first of a new class of twodimensional crystalline materials with unique electronic and mechanical properties,
to Dan Shechtman (2011) for the discovery of quasicrystals (see box on facing page)
and to Robert Lefkowitz and Brian Kobilka (2012) for revealing the inner workings
of an important family of cell receptors which govern nearly every function of the
human body.

In all, 45 scientists have

been awarded the
Nobel Prize over the
past century for work
that is either directly
or indirectly related to
crystallography. There is
not enough room to list
them all in this brochure
but it is thanks to their
individual contributions
that crystallography
has come to underpin
all the sciences. Today,
crystallography remains
a fertile ground for
new and promising
fundamental research.

Crystallography matters!

Equally important was the discovery by father and son team William Henry Bragg
and William Lawrence Bragg in 1913 that X-rays could be used to determine the
positions of atoms within a crystal accurately and unravel its three-dimensional
structure. Known as Braggs Law, this discovery has largely contributed to the modern
development of all the natural sciences because the atomic structure governs the
chemical and biological properties of matter and the crystal structure most physical
properties of matter. The Bragg duo was awarded the Nobel Prize in Physics in 1915.

Crystallography matters!

Why countries need to

invest in crystallography
Crystallography underpins the development of practically all new materials, from
everyday products like computer memory cards to flat television screens, cars and
aeroplane components. Crystallographers not only study the structure of materials
but can also use this knowledge to modify a structure to give it new properties
or to make it behave differently. The crystallographer can also establish the new
materials fingerprint. A company can then use this fingerprint to prove that the new
substance is unique when applying for a patent.
In fact, crystallography has many applications. It permeates our daily lives and forms
the backbone of industries which are increasingly reliant on knowledge generation to
develop new products, including the agro-food, aeronautic, automobile, beauty care,
computer, electro-mechanical, pharmaceutical and mining industries. The following
are a few examples.

New materials are being used

to develop smart clothing.
Smart fabrics let in air or trap
heat, according to whether the
wearer is sweating or shivering.
Inner garments can be equipped
with sensors to monitor body
temperature, breathing rate
and heartbeat, for instance, and
transmit messages to a wearers
cell phone. Outer garments could
be designed to detect threats like
toxic gases, harmful bacteria or
extreme heat. Crystallographers
can identify the properties
needed to develop such new
materials. Sharee Basinger/
publicdomainpictures.net

Mineralogy is arguably the oldest branch of crystallography. X-ray crystallography

has been the main method of determining the atomic structure of minerals and
metals since the 1920s. Virtually everything we know about rocks, geological
formations and the history of the Earth is based on crystallography. Even our
knowledge of cosmic visitors like meteorites comes from crystallography. This
knowledge is obviously essential for mining and any industry which drills into the
Earth, such as the water, oil, gas and geothermal industries.
Drug design is strongly reliant on the use of crystallography. A pharmaceutical
company looking for a new drug to combat a specific bacterium or virus first needs
to find a small molecule capable of blocking the active proteins (enzymes) that are
involved in attacking the human cell. Knowing the precise shape of the protein allows
scientists to design drug compounds that can clamp onto the active sites on the
protein and thereby disable their harmful activity.
Crystallography is also essential to distinguish solid forms of a drug from one another,
as these can be soluble under different conditions, affecting the efficacy of the drug.
This is important for the generic pharmaceutical industry in Asia and Africa especially,
where anti-HIV drugs are being manufactured with compulsory licensing to make
them accessible to the poorest.

Today, crystallographers are able to study a wide variety of materials,

including liquid crystals. Liquid crystal displays are used for the flat
screens of televisions (pictured), computers, cell phones, digital clocks
and so on. The liquid crystal does not produce light itself but rather draws
on an external source such as the back light on a television to form
images, making for low-energy consumption.
@ Shutterstock/Andrey_Popov

Cocoa butter, the most important ingredient of chocolate, crystallizes in six different forms
but only one melts pleasantly in the mouth and has the surface sheen and crisp hardness
that make it so tasty. This tasty crystal form is not very stable, however, so it tends to
convert into the more stable form, which is dull, has a soft texture and melts only slowly in
the mouth, producing a coarse and sandy sensation on the tongue. Luckily, the conversion
is slow but if chocolate is stored for a long time or at a warm temperature, it can develop
a bloom, a white, filmy residue that results from recrystallization. Chocolate-makers thus
have to use a sophisticated crystallization process to obtain the most desirable crystal form,
the only one accepted by gourmets and consumers. Photo: Wikipedia

Antibodies binding to a virus.

Crystallography is used to control
the quality of processed drugs,
including antiviral drugs, at the
stage of mass production, in order to
ensure that strict health and safety
guidelines are met.
IUCr

Crystallography matters!

The Curiosity rover used X-ray crystallography in October 2012 to analyse soil samples on the planet Mars! NASA had equipped the rover
with a diffractometer. The results suggested that the Martian soil sample was similar to the weathered basaltic soils of Hawaiian volcanoes.
Photo: NASA

Crystallography matters!

Who is organizing the

International Year of
Crystallography?
The Year is being organized jointly by the International Union of Crystallography
(IUCr) and UNESCO. It will complement two other international years led by
UNESCO within the United Nations system, by contributing to the follow-up of the
International Year of Chemistry (2011) and providing an introduction to the planned
International Year of Light (2015). UNESCO is implementing all three years through its
International Basic Sciences Programme.

Why now?
The International Year of Crystallography commemorates the centennial of the birth
of X-ray crystallography, thanks to the work of Max von Laue and William Henry and
William Lawrence Bragg. The year 2014 also commemorates the 50th anniversary of
another Nobel Prize, that awarded to Dorothy Hodgkin for her work on vitamin B12
and penicillin (see page 3 A brief history).
Even though crystallography underpins all the sciences today, it remains relatively
unknown to the general public. One aim of the Year will be to promote education and
public awareness through a variety of activities (see overleaf Who will benefit from the
International Year of Crystallography?).
Crystallographers are active in more than 80 countries, 53 of which are members of
the International Union of Crystallography (see map). The Union ensures equal access
to information and data for all its members and promotes international cooperation.
There is a need to broaden the base of crystallography, in order to give more
developing countries expertise in this critical field for their scientific and industrial
development. This is all the more urgent in that crystallography will play a key role in
the transition to sustainable development in coming decades.

Countries adhering to the International Union of Crystallography

IUCr

Challenges for the future

In 2000, the worlds governments adopted the United Nations Millennium
Development Goals, which set specific targets to 2015 for reducing extreme poverty
and hunger, improving access to clean water and safe sanitation, curbing child
mortality and improving maternal health, among other challenges.
Governments are currently preparing a fresh set of goals that will determine the
development agenda for the post-2015 period. The following are some examples of
how crystallography can help to advance this agenda.

Food challenges
The world population is expected to grow from 7 billion in 2011 to 9.1 billion by 2050.
The combination of rapid population growth and a diet more heavily reliant on meat
and dairy products than in the past may increase the demand for food by 70% by
2050. This presents a major challenge for agriculture.
State-of-the-art crystallographic techniques are driving research in the agricultural and
food sectors. Crystallography can be used to analyse soils, for instance. One serious cause
of deteriorating soils is salinization, which can occur naturally or be induced by human
activities.

Crystallography can identify

new materials which can purify
water for months at a time, such
as nanosponges (tap filters)
andnanotablets.
Shutterstock/S_E

Structural studies on plant proteins can help to develop crops which are more
resistant to salty environments.
Crystallography can also contribute to the development of cures for plant and animal
diseases, one example being research into canker in crop species like tomatoes, or the
development of vaccines to prevent diseases such as avian or swine flu.
In addition, crystallographic studies of bacteria are important for the production of
food products derived from milk, meat, vegetables and other plants.

Water challenges

Crystallography can help to improve water quality in poor communities, for instance,
by identifying new materials which can purify water for months at a time, such as
nanosponges (tap filters) and nanotablets. It can also help to develop ecological
solutions to improve sanitation.

Energy challenges
Whereas energy was absent from the Millennium Development Goals, it should
be a key focus of the post-2015 development agenda. In September 2011, the
UN Secretary-General launched the Sustainable Energy for All initiative. It comes
at a time of growing concern over the impact of fossil-fuel intensive economies
on the Earths climate and recognition of the need to accelerate the transition
to sustainable sources of energy. According to the International Energy Agency,
carbon dioxide (CO2) emissions increased by 5% to 30.6 gigatons (Gt) between
2008 and 2010, despite the international financial crisis. If the world is to keep
global warming to 2C this century, CO2 emissions by the energy sector must not
exceed 32 Gt by 2020.

Crystallography matters!

Although the world recently met the Millennium Development Goal target
of halving the proportion of people without access to safe drinking water by
2015, sub-Saharan Africa and the Arab region are lagging behind, according to
the World Water Development Report (2012) produced by the United Nations.
The same target for basic sanitation currently appears out of reach, as half
the population in developing regions still lacks access. Moreover, the number
of people in cities who lack access to a clean water supply and sanitation is
estimated to have grown by 20% since the Millennium Development Goals
were established in 2000. The urban population is forecast to nearly double to
6.3billion in 2050, up from 3.4billion in 2009.

Crystallography matters!

8
Yet global energy consumption is expected to climb by 50% between 2007 and 2035,
with non-OECD countries accounting for 84% of the increase. In 2009, 1.4 billion
people still lacked access to electricity. Demand for energy from renewable resources
is expected to rise by 60% by 2035.
Crystallography can develop new products which lower a homes energy consumption
(and heating bill) while curtailing carbon emissions, such as insulating materials. It can
also identify new materials which reduce the cost of solar panels, windmills and batteries
while making them more efficient, to reduce wastage and improve access to green
technologies.

Greening the chemical industry

Greening the chemical industry will be central to greening the global economy.
The chemical industry manufactures over 70,000 different products, ranging from
plastics and fertilizers to detergents and drugs. It is highly dependent on petroleum,
consuming 10% of global oil production to make 8090% of its products. It is thus
resource- and energy-hungry.
In addition, many solvents and catalysts are toxic and disposal of chemical waste is
complicated and expensive. Toxic and carcinogenic substances are currently being
released into the air, soil and water. According to the United Nations Environment
Programme, Western Europe produced a total of 42 million tonnes of toxic waste in
2000, five million of which were exported a year later.
Crystallography can contribute to the development of ecological construction materials
in developed and developing countries. It can also help to reduce pollution by replacing
chemical solvents with green inorganic solvents based on ionic liquids and CO2. Itcan
help to reduce mining waste and related costs by contributing to methods which
selectively extract only the materials required.

Health challenges
Health challenges will remain daunting in the decades to come. There is still no
effective vaccine or cure for such pandemics as HIV/AIDs, dengue fever and malaria,
for instance, which continue to ravage the developing world in particular.
Many health problems in developing countries are linked to the lack of access to
clean water and safe sanitation, including diaorrheal diseases like cholera or the
chronic disease schistosomiasis, with an estimated 90% of cases at least reported
inAfrica.
However, developing countries are also exposed to the same chronic health burdens
as developed countries, including heart disease, cancer and, increasingly, diabetes
(see photo).
Other serious health concerns that affect rich and poor countries alike include the
emergence of new pathogens and the growing resistance of bacteria to existing
medical treatments.
Crystallography can tackle the growing resistance of bacteria to antibiotics, for instance.
Together with Venkatraman Ramakrishnan and Thomas Steitz, crystallographer
AdaYonath has managed to determine the structure of the ribosome and the way it is
disrupted by antibiotics. Ribosomes are responsible for the production of all proteins in
living cells, including those of humans, plants and bacteria. If the work of the ribosome is
impeded, the cell dies. Ribosomes are a key target for antibiotics, as antibiotics are able
to attack the ribosomal activity of harmful bacteria while leaving human ribosomes
untouched. In 2008, Prof. Yonath was awarded the LOral-UNESCO Prize for Women in
Science for her work and, a year later, all three scientists received the Nobel Prize.
The tropics in particular are blessed with a rich biodiversity that often remains
underexploited. Crystallography can help countries to identify the properties and
behaviour of endogenous plants, with a view to developing skin and health care products,
herbal remedies and so on.

Who will benefit from

the International Year
ofCrystallography?
The Year will target governments
By interacting with them and advising on the design of policies which:
L fi
 nance the establishment and operation of at least one national crystallography
centre per country;
L develop cooperation with crystallography centres abroad, as well as with
synchrotron and other large-scale facilities;
L foster the use of crystallography in research and development;
L foster research in crystallography;
L introduce crystallography into school and university curricula, or modernize
existing curricula.
In addition, a series of regional summit meetings are planned to highlight the
difficulties in conducting first-rate scientific research in parts of the world and
identify ways of overcoming these. The meetings will bring together countries that
are divided by language, ethnicity, religion, or political factors, to delineate future
perspectives for science, technology and related industrial development, and identify
job opportunities.

The Year will target schools and universities

To introduce the teaching of crystallography where it is still absent, via, inter alia:
L travelling laboratories prepared by the International Union of Crystallography
which will demonstrate how diffractometers work in countries in Asia, Africa and
Latin America, in collaboration with diffractometer manufacturers;
L the ongoing Initiative in Africa for universities (see box overleaf), which will be
intensified and extended to countries in Asia and Latin America which lack
crystallography teaching;

In the past 20 years, the number of

people with diabetes worldwide has
risen from 30 million to 230 million,
according to the International
Diabetes Federation. Seven of the top
ten countries for diabetes are either
developing countries or emerging
economies, including China and India.
In the Caribbean and Middle East, about
20% of adults suffer from diabetes.
Had the structure of natural insulin,
produced by the pancreas, not been
determined by X-ray crystallography,
it would be impossible to manufacture
the life-saving biosynthetic human
insulin today. Photo:Wikipedia

L p
 roblem-solving projects for
school pupils which use their
knowledge of crystallography,
physics and chemistry;
L a travelling exhibition for
schools and universities on
Crystallography and Geometric
Art in the Arabo-Islamic World,
organized by the Moroccan
Association of Crystallography (see
box page 12). The exhibition will
also demonstrate crystallization
and X-ray diffraction using a
portable diffractometer.

Crystallography matters!

L h
 ands-on demonstrations and
competitions in primary and
secondary schools;

Crystallography matters!

10
The Year will target the general public
To increase awareness of the way in which crystallography
underpins most of the technological developments in modern
society but also its role in cultural heritage and art history, via:
L p
 ublic conferences organized by members of the
International Union of Crystallography on themes like
the paramount importance of protein crystal structures
in drug design, crystallography and symmetry in art, or
crystallographic analysis of artworks and ancient materials;
L s ponsorship of poster exhibitions highlighting the
usefulness and marvels of crystallography;
L t he submission of articles to the press, television and other
media on the contribution crystallography makes to the
global economy.

Virus. You cannot design drugs without knowing the structure

of relevant proteins. IUCr

DEVELOPING CRYSTALLOGRAPHY AT AFRICAN UNIVERSITIES

One of the International Union of Crystallographys
main missions is to provide faculty and PhD students in
developing countries with training in crystallography
teaching and research methods.

Serah Kimani

In collaboration with South African universities and the

South African Crystallographic Association, the Union
has organized a number of courses over the past decade
in English-speaking African countries. The partnership
has also awarded a fellowship to two exceptional
PhD students from Kenya, Serah Kimani (pictured)
and Ndoria Thuku, to enable them to complete their
theses in South Africa. Serah Kimanis thesis involved
determining as many as 40 crystal structures. She took
up an appointment at the University of Cape Town in
2012. Ndoria Thukus thesis involved determining the
crystallographic structure of Rhodococcus rhodochrous,
a bacterium used as a soil inoculant to promote plant
health in agriculture and horticulture. Since graduating in
2012, Dr Thuku has been a postdoctoral research fellow in
the Division of Medical Biochemistry at the University of
Cape Town.

In 2011, the International Union of Crystallography designed an ambitious programme for sub-Saharan African countries.
Known as the Crystallography in Africa Initiative, the programme not only trains teaching staff and PhD students in
crystallography but also provides participating universities with diffractometers worth between 80,000 and 150,000 euros
each, in order to enable them to conduct international research. A key partner in this endeavour is Bruker France, a private
enterprise which has agreed to supply diffractometers in perfect working order to all the universities identified by the
Union. The Union covers the cost of delivering the diffractometer to each university. In return, the recipient universities
maintain the diffractometer and cover the cost of related equipment, such as the computer and X-ray tube.

The Year will target the scientific

community
To foster international collaboration between
scientists worldwide, with an emphasis on
NorthSouth collaboration, via:
L t he launch of an open access journal on
crystallography, which will be called IUCrJ;
L joint research projects involving large
synchrotron facilities in both developed and
developing countries, such as the facility in Brazil
or the SESAME facility in the Middle East, born of
a UNESCO project (see photo page 14);
L c onsultations to identify the best way to save all
diffraction data collected in large-scale facilities
and crystallography laboratories.

Cover of the first issue of the new open

access journal, available at: www.iucrj.org

The first faculty staff to be trained in how to use these instruments comes from the University of Dschang in Cameroon.
Teaching staff and PhD students were given an intensive 20-hour course in February 2012, in order to prepare them for the
arrival of the diffractometer the following year.
The Cameroon Crystallographic Association was founded at this time. The fledgling association ran its first course from 7
to 13 April 2013 in Dschang. The course focused on how to use diffraction to determine crystalline structures and attracted
24 professors and PhD students from universities across Cameroon and the wider sub-region. It was cofinanced by the
International Union of Crystallography, Cameroon Crystallographic Association, University of Dschang and Bruker.

The International Union of

Crystallography is currently contacting
other sponsors, in order to generalize the
Crystallography Initiative in Africa across
the entire continent.
The International Year of Crystallography
should also make it possible to extend the
initiative to developing countries in Asia
and Latin America.
For details:
[email protected]

Prof. Claude Lecomte, Vice-President of the IUCr, teaching a crystallography

course at the University of Dschang in Cameroon in February 2012
Patrice Kenfack/Cameroon Crystallographic Association

Crystallography matters!

The next countries to benefit from the

initiative will be Cte dIvoire, Gabon and
Senegal. One university is being targeted
in each country. This university will in turn
be expected to train staff at other national
universities and to act as a national
crystallographic centre. Each national
centre will be entitled to free access to the
International Union of Crystallographys
specialist publications.

11

Crystallography matters!

12
SYMMETRY IN ART AND ARCHITECTURE
Be it a human face, a flower, a fish, a butterfly or a non-living object like a seashell , symmetry pervades the natural world. It has
always fascinated human civilizations, which have reflected symmetry in their art and architecture for thousands of years.
Symmetry can be found in all human expressions of creativity: carpets and rugs, pottery, ceramics,
drawing, painting, poetry, sculpture, architecture, calligraphy, etc. There is symmetry in the Chinese
alphabet, for instance. Symmetry in Chinese art and architecture is a manifestation of the Chinese
philosophy of seeking harmony through balance.
Art and architecture may demonstrate different forms of symmetry.
A pattern that repeats itself indefinitely is said to show
translational symmetry. Itcan be one-dimensional like
the frieze below, or two-dimensional like the winged
animals in the imagehere.

Chinese
symbol for
happiness,
pronounced
shuangxi

In bilateral symmetry, the left and right sides are

mirror images of one another. One example in
nature is a butterfly. Bilateral symmetry has
always been a common feature of architecture,
historic examples being the Taj Mahal in
India (pictured), the Forbidden City in China or
the Mayan temple of Chichen Itza in Mexico
(pictured). Bilateral symmetry is also common in art,
although perfect symmetry in painting is rare.

If a figure can be
rotated about its axis or
a particular point without
changing the way it looked
originally, it is said to show
rotational symmetry. The pyramids
of Giza in Egypt, for instance, show
rotational symmetry of order four (including
the base). The interior of the dome of the Lotfollah Mosque in Iran
(pictured) shows rotational symmetry of order 32, starting around the
point located at the centre of the figure.

Yoruba bronze head from the

Nigerian city of Ife, 12thcentury CE
Photo: Wikipedia

Two-dimensional image by Maurits Cornelis Escher (Netherlands)

M C Escher Foundation

Geometric patterns have pervaded the art of many civilizations.

Examples are the sand paintings of the Navajo Indians in North America,
the kolam of south India (pictured), Indonesian batik (tie-dyeing), the art
of Australian Aborigines and Tibetan mandalas.

Taj Mahal, India, completed in 1648, today a UNESCO World

Heritage property
Photo: Muhammad Mahdi Karim/Wikipedia

Mayan temple in Chichen Itza in Mexico, which flourished from about

600 to 900 CE, today a UNESCO World Heritage property
S. Schneegans/UNESCO

Islamic civilizations from about the 7th century onwards

used geometric patterns in mosaics and other art
forms to connect spirituality visually with science and
art. Islamic art may have inspired the Western school
of geometric abstraction of the 20th century, two
proponents of which were Maurits Cornelis Escher and
Bridget Riley (pictured). Escher was reputedly inspired by
a visit to the Moorish palace of Alhambra in Spain.
Throughout 2014, the Moroccan Crystallographic
Association is organizing a travelling exhibition on
Crystallography and Geometric Art in the Arabo-Islamic
World. For details, write to:
Abdelmalek Thalal: [email protected]

Kolams like this one in Tamil Nadu are drawn in rice powder or chalk
in front of homes to bring prosperity. They can be renewed daily.
Photo: Wikipedia

Al-Attarine Madrasa (school) in Fez, Morocco, a World Heritage property. It was built by
theMarinidSultan Uthman II Abu Said in 13231325.
A. Thalal

Shadow Play by Bridget Riley, UK, 1990

Photo: Wikipedia
One-dimensional frieze
Image: Moroccan Crystallographic Association

Crystallography matters!

Dome-shaped ceiling of the Lotfollah Mosque in Iran, completed

in 1618, today a UNESCO World Heritage property
Photo: Phillip Maiwald/Wikipedia

13

Crystallography matters!

14

How can my country boost

crystallography in 2014
andbeyond?
Any country interested in developing knowledge-based industries or adding value to
raw products must have an endogenous capacity in crystallography. During the Year,
developing countries in Africa, the Arab region, Latin America, the Caribbean and Asia
can do a lot to boost crystallography on their soil.

Ways to improve training and research

The completed shielding wall

in the experimental hall of
the SESAME synchrotron light
source in the Middle East, an
intergovernmental centre in
Jordan that has been set up
under the auspices of UNESCO
and brings together Bahrain,
Cyprus, Egypt, Iran, Israel,
Jordan, Pakistan, the Palestinian
Authority and Turkey, as well as
13Observer States that include
Japan and the USA. The SESAME
building was completed in 2008
and the laboratory should be
fully operational by early 2016.
SESAME

As we have seen, crystallography is an interdisciplinary science that spans

physics, chemistry, materials science, geology, biology, pharmaceutics and
medicine. Scientists with a background in any of these fields are thus potential
crystallographers. Throughout 2014, the International Union of Crystallography
will be encouraging more countries to become members, in order to facilitate
international cooperation in training and research, as well as access to information
and knowledge.
Once trained, crystallographers need appropriate infrastructure, in order to apply
their skills. UNESCO and the International Union of Crystallography recommend
that governments set up at least one national crystallography centre equipped
with a diffractometer and that they endow it with sustained funding. Once the
diffractometer has finished analysing the structure of a crystal, the crystallography
centre can then model it using crystallographic software. As partners in the Year,
diffractometer manufacturers will guarantee an affordable price for the purchase of a
diffractometer and offer local training in maintaining these instruments.
It is important for the government to put policies in place which facilitate the
centres linkages with universities and industry within the country, as well as with
other crystallography centres around the world, in order to drive knowledge-based
sustainable development.

The government should also foster the development of ties between the national
crystallography centre and national and international synchrotron light sources like
SESAME in Jordan (see photo).
In order to share knowledge of scientific and technological developments in
crystallography and give greater visibility to the publications of crystallographers
from developing countries in particular, the International Union of Crystallography is
launching an open-access journal on crystallography, IUCrJ (see photo page 11).
UNESCO and the International Union of Crystallography are also encouraging
governments to set up regional or sub-regional hubs offering training and
experimentation in crystallography, in order to rationalize resources for institutional
capacity-building.

Training the crystallographers of tomorrow

Now is the time for countries to train a critical mass of crystallographers. Governments
can take steps to modernize school and university curricula by fostering a better
correlation with crystallography in the curricula of physics, chemistry, biology and
geology. UNESCO and the International Union of Crystallography are at governments
disposal to provide guidance on curricular development.
They also invite governments to express interest in hosting the travelling laboratory
on crystallography that has been designed specifically for youth.

Crystallography matters!

The International Union of Crystallography has also devised problem-solving projects

and competitions for schools which use their knowledge of crystallography, physics
and chemistry. The aim is to demonstrate the practical applications of these sciences for
the development of agriculture, drug design, green new materials and so on. Countries
are invited to express interest in organizing such competitions at the national level.

15

Crystallography matters!

16

To participate in the
International Year of Crystallography
The 195 Member States of UNESCO are invited to contact UNESCOs team within the International Basic Sciences
Programme (IBSP) or the International Union of Crystallography, in order to put together a programme for
implementation in their country in 2014.

International Union of Crystallography

UNESCO

Prof. Gautam Desiraju,

President: [email protected]

Prof. Maciej Nalecz, Director,

Executive Secretary of International Basic Sciences
Programme: [email protected]

Prof. Claude Lecomte,

Vice-President: [email protected]
Dr Michele Zema,
Project Manager for the Year: [email protected]

Crystallography helps to determine the ideal combination

of aluminium and magnesium in alloys used in aeroplane
manufacture. Too much aluminium and the plane will be too
heavy, too much magnesium and it will be more flammable.
Shutterstock/IM_photo

Dr Jean-Paul Ngome Abiaga, Assistant Programme

Specialist: [email protected]
Dr Ahmed Fahmi,
Programme Specialist: [email protected]

The programme of events for the Year and relevant teaching

resources are available from the officialwebsite:

www.iycr2014.org

Crystallography matters!

For more information on the International Year of Crystallography:

International Union of Crystallography

UNESCO

Prof. Gautam Desiraju,

Prof. Maciej Nalecz, Director,

President: [email protected]

Executive Secretary of International Basic Sciences

Prof. Claude Lecomte,

Vice-President: [email protected]
Dr Michele Zema,
Project Manager for the Year: [email protected]

Programme: [email protected]
Dr Jean-Paul Ngome Abiaga,
Assistant Programme Specialist: [email protected]
Dr Ahmed Fahmi,
Programme Specialist: [email protected]

w w w.iycr2014.org