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    Drug Study Generic Name (Brand Name) Indication Dosage, Route, Frequency Mechanism of Action Adverse Reaction Contraindication Nursing Responsibility

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    Kimm Charmaine Rodriguez
    This document summarizes information about two drugs used in obstetrics: methylergonovine and oxytocin. Methylergonovine is used to prevent and treat postpartum and postabortion hemorrhage by stimulating uterine contractions. It can cause cardiovascular, neurological, gastrointestinal, and other adverse effects. Oxytocin is used to induce labor, control postpartum bleeding, and assist with abortion management. It stimulates uterine contractions and milk ejection. It is contraindicated in cases of cephalopelvic disproportion or transverse lie requiring conversion. It can cause hypertension, increased heart rate, nausea/vomiting, anoxia, asphyxia, and low APGAR

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    Drug Study Generic Name (Brand Name) Indication Dosage, Route, Frequency Mechanism of Action Adverse Reaction Contraindication Nursing Responsibility

    Uploaded by

    Kimm Charmaine Rodriguez
    134 views3 pages
    This document summarizes information about two drugs used in obstetrics: methylergonovine and oxytocin. Methylergonovine is used to prevent and treat postpartum and postabortion hemorrhage by stimulating uterine contractions. It can cause cardiovascular, neurological, gastrointestinal, and other adverse effects. Oxytocin is used to induce labor, control postpartum bleeding, and assist with abortion management. It stimulates uterine contractions and milk ejection. It is contraindicated in cases of cephalopelvic disproportion or transverse lie requiring conversion. It can cause hypertension, increased heart rate, nausea/vomiting, anoxia, asphyxia, and low APGAR

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    Drug Study

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    This document summarizes information about two drugs used in obstetrics: methylergonovine and oxytocin. Methylergonovine is used to prevent and treat postpartum and postabortion hemorrhage by stimulating uterine contractions. It can cause cardiovascular, neurological, gastrointestinal, and other adverse effects. Oxytocin is used to induce labor, control postpartum bleeding, and assist with abortion management. It stimulates uterine contractions and milk ejection. It is contraindicated in cases of cephalopelvic disproportion or transverse lie requiring conversion. It can cause hypertension, increased heart rate, nausea/vomiting, anoxia, asphyxia, and low APGAR

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    134 views3 pages

    Drug Study Generic Name (Brand Name) Indication Dosage, Route, Frequency Mechanism of Action Adverse Reaction Contraindication Nursing Responsibility

    Uploaded by

    Kimm Charmaine Rodriguez
    This document summarizes information about two drugs used in obstetrics: methylergonovine and oxytocin. Methylergonovine is used to prevent and treat postpartum and postabortion hemorrhage by stimulating uterine contractions. It can cause cardiovascular, neurological, gastrointestinal, and other adverse effects. Oxytocin is used to induce labor, control postpartum bleeding, and assist with abortion management. It stimulates uterine contractions and milk ejection. It is contraindicated in cases of cephalopelvic disproportion or transverse lie requiring conversion. It can cause hypertension, increased heart rate, nausea/vomiting, anoxia, asphyxia, and low APGAR

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    © All Rights Reserved
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    Download as docx, pdf, or txt
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    DRUG STUDY

    Generic Name
    (Brand Name)
    Indication Dosage, Route,
    Frequency
    Mechanism of
    Action
    Adverse Reaction Contraindication Nursing
    Responsibility

    Methylergonovine
    maleate

    Methergine

    Methylergobasine

    Methylergobrevin

    Methylergonovine)

    Prevention and
    treatment of
    postpartum and
    postabortion
    hemorrhage
    caused by uterine
    atony or
    subinvolution

    2 Ampules
    immediately after
    the delivery of
    the Placenta

    Methergine

    Stimulates
    uterine smooth
    muscles

    producing
    sustained
    contractions

    thereby shortens
    the third stage of
    labor


    Cardiovascular:
    hypertension,
    temporary chest
    pain, palpitation
    CNS:Hallucinations,
    dizziness, seizure,
    headache
    Gastrointestinal:
    Nausea, vomiting,
    diarrhea, foul taste
    Local:
    Thrombophlebitis
    Otic: Tinnitus
    Renal: Hematuria
    Respiratory:
    Dyspnea, nasal
    congestion


    > contraindicated
    in patients
    hypersensitive to
    methylergonovine
    or any component
    of the
    formulation.
    >ergot alkaloids
    are
    contraindicated
    with potent
    inhibitors of
    CYP3A4 (includes
    protease
    inhibitors, azole
    antifungals, and
    some macrolide
    antibiotics);
    >hypertension;
    toxemia of
    pregnancy (PIH)


    >Be alert for
    adverse reactions
    and drug
    interactions.
    >This drug should
    be used extremely
    carefully because
    of it's potent
    vasoconstrictor
    action. I.V. use
    may induce
    sudden
    hypertension and
    cerebrovascular
    accidents. As a
    last resort, give
    I.V. slowly over
    several minutes
    and monitor
    blood pressure
    closely.
    >Monitor Uterine
    Contractions

    Generic Name
    (Brand Name)
    Indication Dosage, Route,
    Frequency
    Mechanism of
    Action
    Adverse Reaction Contraindication Nursing
    Responsibility



    Oxytocin

    (Syntocinon)




    Induction of labor
    at term; control of
    postpartum
    bleeding;
    adjunctive therapy
    in management of
    abortion





    10 units/ml in
    1ml ampule, vial
    or syringe in
    compatible IV
    solution.





    to induce or milk
    ejection and
    stimulate
    contraction



    Hypersensitive
    to drug when
    vaginal delivery
    is advised

    - cephalopelvic
    disproportion is
    present

    -when delivery
    requires
    conversion as in
    transverse lie


    CV:
    Hypertension,
    increased heart
    rate, systemic
    venous return,
    cardiac output

    GI: Nausea,
    vomiting

    RESPIRATORY:
    Anoxia, asphyxia

    OTHERS:
    Low APGAR
    score at 5 mins.


    Continuously
    monitor
    contractions,
    fetal and
    maternal
    heart rate, and
    maternal
    blood
    pressure and
    ECG.
    Discontinue
    infusion if
    uterine
    hyperactivity
    occurs.

    Monitor
    patient
    extremely
    closely during
    first and
    second stages
    of labor
    because of risk
    of cervical
    laceration,
    uterine
    rupture and
    maternal and
    fetal death.

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