Nucleus & Nucleolus: by Dan Intartaglio & Joel Skivington
Nucleus & Nucleolus: by Dan Intartaglio & Joel Skivington
Nucleus & Nucleolus: by Dan Intartaglio & Joel Skivington
History
-Discovered in 1831 by Scottish botanist Robert Brown -Suggested the nucleus played a key role in fertilization and development of the embryo in plants
-Name (nucleus) derived from the Latin word for kernel/nut
Robert Brown 1773-1858
Main Characteristics
Membrane-enclosed organelle found in eukaryotic cells Generally found in the central region of the cell (in animal cells) Roughly spherically shaped Largest and most easily seen organelle
Houses
the nucleolus
for production of ribosomes
Responsible Selective
Structure
Nuclear Envelope
Consists of:
Phospholipid
Nuclear
Ribosomes
Nuclear Pores
Allow small molecules to diffuse easily between nucleoplasm & cytoplasm Control passage of proteins & RNA protein complexes
Import: proteins moving in to be incorporated into nuclear structure or to catalyze nuclear activities Export: RNA / RNA-protein complexes to the cytoplasm
Nucleolus
Largest
structure present inside the boundaries of the nucleus staining zone in center of nucleus
Dark
Where
intensive synthesis of ribosomal RNA takes place components are ribonucleic acid (RNA), deoxyribonucleic acid (DNA) and proteins
Main
Progeria
Caused by a mutation in gene LMNA (Lamin-A) LMNA gene produces the Lamin A protein, which is the structural scaffolding that holds the nucleus of a cell together Defective Lamin A protein makes the nucleus unstable. That nuclear instability appears to lead to the process of premature aging in Progeria.
Questions
What
What
Photosynthesis Production of proteins Storage of genetic material Import / Export of specific molecules