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    Patho MI

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    banyenye25
    Myocardial infarction is caused by a blockage in the coronary arteries that reduces blood flow and oxygen to the heart muscle. Risk factors include age, smoking, obesity, high blood pressure, diabetes, and diet. When oxygen demand exceeds supply, the heart cells switch to anaerobic metabolism which builds up lactic acid and damages cell membranes, altering heart muscle contraction and decreasing cardiac output. This triggers baroreceptors and sympathetic receptors to increase heart rate and contractility further worsening the ischemia.

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    Patho MI

    Uploaded by

    banyenye25
    2K views2 pages
    Myocardial infarction is caused by a blockage in the coronary arteries that reduces blood flow and oxygen to the heart muscle. Risk factors include age, smoking, obesity, high blood pressure, diabetes, and diet. When oxygen demand exceeds supply, the heart cells switch to anaerobic metabolism which builds up lactic acid and damages cell membranes, altering heart muscle contraction and decreasing cardiac output. This triggers baroreceptors and sympathetic receptors to increase heart rate and contractility further worsening the ischemia.

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    pathophysiology of myocardial infarction

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    patho MI

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    Myocardial infarction is caused by a blockage in the coronary arteries that reduces blood flow and oxygen to the heart muscle. Risk factors include age, smoking, obesity, high blood pressure, diabetes, and diet. When oxygen demand exceeds supply, the heart cells switch to anaerobic metabolism which builds up lactic acid and damages cell membranes, altering heart muscle contraction and decreasing cardiac output. This triggers baroreceptors and sympathetic receptors to increase heart rate and contractility further worsening the ischemia.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    2K views2 pages

    Patho MI

    Uploaded by

    banyenye25
    Myocardial infarction is caused by a blockage in the coronary arteries that reduces blood flow and oxygen to the heart muscle. Risk factors include age, smoking, obesity, high blood pressure, diabetes, and diet. When oxygen demand exceeds supply, the heart cells switch to anaerobic metabolism which builds up lactic acid and damages cell membranes, altering heart muscle contraction and decreasing cardiac output. This triggers baroreceptors and sympathetic receptors to increase heart rate and contractility further worsening the ischemia.

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    PATHOPHYSIOLOGY OF MYOCARDIAL INFARCTION ETIOLOGY: FACTORS

    Coronary atherosclerotic heart disease Coronary thrombosis/Embolism Decrease blood flow with shock & or hemorrhage Direct trauma -

    RISK
    age smoking obesity HPN diabetes diet

    Imbalance of blood supply and demand Myocardial ischemia

    Occlusion of coronary artery Cellular processes compromised Decrease of oxygen Cell switch to anaerobic metabolism Lactic acid builds up in the cell Cell membrane permeability Specific enzyme release Stimulation of nerve fibers Pain impulses to the CNS
    Increased peripheral vasoconstriction

    Decrease of myocardial oxygen supply Increased cellular hypoxia Altered cell membrane Int. Decrease of myocardial contractility Decreased cardiac output Decreased arterial pressure Stimulation of baroreceptors Stimulation of sympathetic receptors

    Increased myocardial contractility Increased HR Decreased diastolic filling Decreased myocardial tissue perfusion

    Increased after load

    Increased myocardial oxygen demand

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