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Cytokines: Cytokine Source Target/Effect Other

Cytokines are signaling molecules that are produced by immune cells to mediate and regulate immunity and inflammation. The table lists various cytokines including their source cell, target cells, and main effects. TNF and IL-1 are produced early in inflammation by macrophages and endothelial cells and target endothelial cells to increase vascular permeability and recruit leukocytes. IL-2 stimulates proliferation of T cells. IL-6 is produced by macrophages and endothelial cells and acts on the liver to induce synthesis of acute phase proteins.

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104 views1 page

Cytokines: Cytokine Source Target/Effect Other

Cytokines are signaling molecules that are produced by immune cells to mediate and regulate immunity and inflammation. The table lists various cytokines including their source cell, target cells, and main effects. TNF and IL-1 are produced early in inflammation by macrophages and endothelial cells and target endothelial cells to increase vascular permeability and recruit leukocytes. IL-2 stimulates proliferation of T cells. IL-6 is produced by macrophages and endothelial cells and acts on the liver to induce synthesis of acute phase proteins.

Uploaded by

mcwnotes
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
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Cytokines

Cytokine Source Target/Effect Other


TNF (Tumor MØ, T-cells Endothelial: activation (inflamm, coag, vascular Acute inflammatory
Necrosis leak) response to Gram(-)
Factor) Neutrophils: activation bacteria
Hypothalamus: fever
Liver: synth acute phase proteins
Muscle/Fat: catabolism (cachexia)
Many cell types: apoptosis
IL-1 MØ, endothelial cells, Endothelial: activation (inflamm, coag) “Hot
some epithelial cells Hypothalamus: fever
Liver: synth acute phase proteins
Recruits leukocytes via chemokine production
IL-2 TH cells Effector T-cell: proliferation** T-
T-Reg: growth and survival ↑↑ expression of B7
NK cells, B-cells: proliferation and differentiation
IL-3 T-cells (CD4+) Promotes expansion of immature marrow Multilineage Colony
progenitors of all blood cells Stimulating Factor
(Multi-CSF)
Bone
IL-4 TH2 cells TH2 cell differentiation from naïve CD4+ precursors StE-
Stimulation of IgE from B-cells
Suppression of IFN-γ dependant MØ fxns
IL-5 TH2 cells, mast cells Eosinophils: growth and differentiation and -Ak”
activation of mature eosinophils
B-Cells: promotes differentiation and IgA class
switching
IL-6 MØ, endothelial cells, T- Liver: Synth of acute phase proteins
cells B-cells: proliferation of Ab producing cells
IL-8 MØ Neutrophils: recruitment “clean up on aisle 8”
IL-10 MØ, T-cells (TH2) Macrophages: inhibition of IL-12 production, ↓ Potent anti-
expression of co-stimulators and MHC-II inflammatory
IL-12 MØ, dendritic cells NK and T-cells: IFN-γ synth, ↑ cytosolic activity
T-cells: TH1 differentiation
IL-13
IL-15 MØ NK and T-cells: proliferation
IL-18 MØ NK and T-cells: IFN-γ synth
IFN-α, -β α- MØ All Cells: antiviral state, ↑ MHC-I expression
β- Fibroblasts NK cells: activation
IFN-γ NK cells, T-cells Macrophage: activation
Stimulation of some Ab responses
Suppress IL-4
TGF-β Activated T-cells (CD4+), T-cells: inhibit proliferation and differentiation
MØ, others MØ: inhibit activation
Counteract effects of pro-inflammatory cytokines
Complements
Eicosanoids, Phagocytes, MØ, others Phagocyte recruitment and activation
NO, ROI Microbial killing
Defensins Phagocytes, MØ, others Lyse microbes Small cationic
peptides
Acute Phase Liver (from IL-6 stim) Bind to microbes and enhance phagocytosis, stim
Reactants phagocyte recruitment and activation

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