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PI3 Kinase Akt Signaling: mTORC2

This document provides an overview of the PI3K/Akt signaling pathway. It shows that mTORC2 activates Akt which then activates or inactivates many downstream targets involved in processes like protein synthesis, glucose metabolism, cell survival, proliferation, and neuroscience. These targets include factors like GSK-3, TSC1/2, FoxO1, and MDM2. The diagram also indicates how various receptors and proteins can activate or inhibit nodes within this complex signaling network.

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92 views0 pages

PI3 Kinase Akt Signaling: mTORC2

This document provides an overview of the PI3K/Akt signaling pathway. It shows that mTORC2 activates Akt which then activates or inactivates many downstream targets involved in processes like protein synthesis, glucose metabolism, cell survival, proliferation, and neuroscience. These targets include factors like GSK-3, TSC1/2, FoxO1, and MDM2. The diagram also indicates how various receptors and proteins can activate or inhibit nodes within this complex signaling network.

Uploaded by

alexandru_mg3
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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mTORC2

Akt
Akt
p70 S6K
P
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3
K
P
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3
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P
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GSK-3
PHLPP CTMP
Lamin A
PP2A
Tpl2
IKK
eNOS
GS
Bad
Bcl-2
FoxO1
TSC1
TSC2
PDCD4
AS160
PFKFB2
PIP5K
S6
p53
MDM2
Bim
Bax
p27 Kip1
p21
Waf1/Cip1
14-3-3
Cyclin D1
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GTP
PTEN
PDK1
Syk
Jak1
FAK
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XIAP
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PTEN
Integrin
Cytokine
Receptor
PDK1
G
BCAP
Lyn
Ag
Ataxin-1
Huntingtin
GABA
A
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PRAS40
GPCR
RTK
CD19
BCR
PIP
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3
mTOR
Rictor
Sin1 PRR5
GL
DEPTOR
Raptor
GL
mTOR
DEPTOR
mTORC1
mTORC1
mTORC2
4E-
BP1
ATG13
/
/
Blocks
Aggregation
Promotes
Neuroprotection
Synaptic
Signaling
mIg
mIg
Cytosolic
Sequestration
Cardiovascular
Homeostasis
NF-B
Pathway
Organization
of Nuclear
Proteins
Cell Cycle
Apoptosis
Aggregation
Neurodegeneration
Inhibits Apoptosis
Inhibits
Autophagy
Glycogen
Synthesis
Glucose
Transport
Glycolysis
Membrane
Recruitment
and Activation
Membrane
Recruitment
and Activation
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PI3 Kinase Akt Signaling
www.cellsignal.com
2003 2011 Cell Signaling Technology, Inc. PI3K / Akt Signaling created January 2003 revised October 2011
Direct Stimulatory Modification
Kinase
Phosphatase
Caspase
Receptor
Cyclin, pro-apoptotic
Enzyme
pro-survival
GAP / GEF
GTPase
G-protein, ribosomal subunit
Transcription Factor
Transcriptional Stimulation
Transcriptional Inhibition
Translocation
Separation of Subunits or Cleavage Products
Joining of Subunits
Direct Inhibitory Modification
Multistep Stimulatory Modification
Multistep Inhibitory Modification
Tentative Stimulatory Modification
Tentative Inhibitory Modification
Signaling Pathways Key
www.cellsignal.com
2003 - 2010 Cell Signaling Technology, Inc.
Acetylase
Deacetylase

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