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Sorini

Sorini is an anti-inflammatory analgesic with the generic name Nimesulide. It is used to treat painful or non-painful inflammatory conditions affecting soft tissue or musculoskeletal systems as well as dysmenorrhea, post-op pain, and dental inflammation. Nimesulide is rapidly absorbed after oral administration and extensively bound to plasma proteins with an average half-life of 3 hours. Common adverse reactions include mild transient heartburn, nausea, and stomachache while rare reactions include purpura, vertigo, and Stevens-Johnson syndrome. Nimesulide is contraindicated in patients with peptic ulcer, gastrostaxis, pregnancy, lactation or children and those with hypersensitivity to NSAIDs.

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207 views2 pages

Sorini

Sorini is an anti-inflammatory analgesic with the generic name Nimesulide. It is used to treat painful or non-painful inflammatory conditions affecting soft tissue or musculoskeletal systems as well as dysmenorrhea, post-op pain, and dental inflammation. Nimesulide is rapidly absorbed after oral administration and extensively bound to plasma proteins with an average half-life of 3 hours. Common adverse reactions include mild transient heartburn, nausea, and stomachache while rare reactions include purpura, vertigo, and Stevens-Johnson syndrome. Nimesulide is contraindicated in patients with peptic ulcer, gastrostaxis, pregnancy, lactation or children and those with hypersensitivity to NSAIDs.

Uploaded by

ianecunar
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as DOC, PDF, TXT or read online on Scribd
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Brand Name: Sorini

Generic Name: Nimesulide


Indications: Painful or non painful inflammatory condition affecting soft tissue or
musculoskeletal system, dysmenorrhea, post op pain, inflammation of dental
tissue, RA, acute inflammation on upper airway.
Drug Classification: Anti-rheumatic, anti-inflammatory analgesics.
Mechanism of action: Nimesulide is rapidly (peak plasma concentration in 1-4 hours)
and extensively absorbed after oral administration. The drug can be given as
rectal suppository but it is about 70% as bioavailable rectally as orally
administered. The compound is extensively bound to plasma proteins. The
average half-life of administration is about 3 hours. Nimesulide is metabolized
primarily to alphe, 4-hydroxy derivative and metabolites are primarily excreted
from the kidney.
Dosage: Adult: 50-100 mg bid, if necessary up to 200 mg bid. Mild cases and long
tyherapy 75-100mg daily.
Special Precaution: Elderly, weak patients with bleeding disease or upper gastric
disease, on anticoagulant or antiplatelet drug.
Pregnancy Risk Category:
Adverse reaction: Occasionally mild transient heartburn, nausea, stomachache. Rarely
purpura, vertigo, drowsiness, erythema, exsudativum multiforme, Stevens-
Jonhson syndrome, peptic ulcer, GI bleeding, perforation and bloody excrement.
Contraindication: Peptic ulcer, gastrostaxis, pregnancy, lactation and children.
Hypersensitivity to NSAIDs
Form: Tab 100 mg
Nursing Responsibilities:
 Monitor patient for adverse reactions.
 Screen for any of the following known allergies to salicylates, NSAIDs, or
tartrazine, renal disease, bleeding disorder, chicken pox or influenza.

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