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    BCA With Brain Mets Patho

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    Jen Garzo
    The document discusses the stages of broncho-genic carcinoma or lung cancer that has metastasized to the brain. It covers the predisposing factors, carcinogenesis process, and stages I through IV. Stage IV cancer has spread to major organs including the brain, causing excruciating pain, blurred vision, headaches and other neurological symptoms. The prognosis is poor if not treated at this advanced stage.

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    BCA With Brain Mets Patho

    Uploaded by

    Jen Garzo
    24 views2 pages
    The document discusses the stages of broncho-genic carcinoma or lung cancer that has metastasized to the brain. It covers the predisposing factors, carcinogenesis process, and stages I through IV. Stage IV cancer has spread to major organs including the brain, causing excruciating pain, blurred vision, headaches and other neurological symptoms. The prognosis is poor if not treated at this advanced stage.

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    The document discusses the stages of broncho-genic carcinoma or lung cancer that has metastasized to the brain. It covers the predisposing factors, carcinogenesis process, and stages I through IV. Stage IV cancer has spread to major organs including the brain, causing excruciating pain, blurred vision, headaches and other neurological symptoms. The prognosis is poor if not treated at this advanced stage.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
    Download as doc, pdf, or txt
    24 views2 pages

    BCA With Brain Mets Patho

    Uploaded by

    Jen Garzo
    The document discusses the stages of broncho-genic carcinoma or lung cancer that has metastasized to the brain. It covers the predisposing factors, carcinogenesis process, and stages I through IV. Stage IV cancer has spread to major organs including the brain, causing excruciating pain, blurred vision, headaches and other neurological symptoms. The prognosis is poor if not treated at this advanced stage.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
    Download as doc, pdf, or txt
    of 2

    BRONCHOGENIC CARCINOMA STAGE IV WITH BRAIN METASTASIS ;) Predisposing Factors Age Gender Genetics ?? I need more ???

    Precipitating Factors Lifestyle Diet Environment Occupation

    Carcinogens will enter the Respiratory System

    Initiation: Deoxyribonucleic Acid Mutation due to Carcinogenic Agents

    Alteration of the ras proto oncogenes = Proto oncogenes turns to oncogenes Inactivation of the P53 tumor suppressor gene on chromosome 17

    Promotion: an initiated cell undergoes clonal expansion to form pre-neoplastic lesion Conversion: Pre-neoplastic lesion undergo further genetic change

    MALIGNANT TUMOR DEVELOPS

    Stage I:
    Tumor is confined in the Lung

    Asymptomatic Chronic Cough Chest Pain Shortness of Breath Coin Lesion (CXR) Stage 1 B

    Stage 1 A

    If treated: Stage IIIA - Chemotherapeutic Drugs - Radiation Therapy - Surgery (Lobectomy, Pneumonectomy) If treated: - Chemotherapeutic Drugs Cessation/Delay of Radiation Therapy Tumor Growth

    If not treated: Stage IIIB

    Conversion:
    Pre-neoplastic lesion undergo further genetic change If not treated:

    Tumor increase in size

    Delay of Tumor Growth

    Stage II
    Tumor is confined to the chest

    Stage IV

    Tumor spreads to major organs of the body Stage II A

    Chronic Cough, Shortness of Breath, Chest Pain, Wheezing, Hemoptysis, Symptoms depend on increase in tumor size organ involved. Brain Metastasis: Excruciating pain Brain: Blurred vision, head ache, seizure, II B symptoms ofStage stroke or loss of sensations

    If treated: - Chemotherapeutic If treated: Drugs Chemotherapeutic - Radiation Therapy Drugs - Radiation Therapy - Surgery Delay of Tumor (Lobectomy, Growth Pneumonectomy, lymphadenectomy) Poor Prognosis Cessation/Delay of Tumor Growth

    If not treated: If not further treated: Tumor spreads to major Tumor organs of increase the in body size

    Multi-organ System Failure Cough, Wheezing, Chest DEATH Pain, hemoptysis, RIP? :D shortness of breath, hoarseness of voice, dysphagia, anorexia, weight loss, clubbing of the fingers, cyanosis

    Stage III
    Tumor is confined to the chest but nearby tissues are affected

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