Physician'S Order Sheet: Sepsis Adult
Physician'S Order Sheet: Sepsis Adult
patient imprint
PHYSICIAN'S ORDER SHEET
Sepsis Adult
Another brand of a generically equivalent product identical in dosage
form and content of active ingredient may be administered unless
indicated.
Allergies: ____________________
Admission Status g Central venous catheter management
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g Admit to inpatient to Dr. ______service.
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f c Elevate head of bed if tolerated to _____ degrees.
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c Admit to observation to Dr. _________ service.
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g c Nasogastric/orogastric tube insertion/management
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Admit Location c Peripheral arterial catheter management
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c Admit to location __________________
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g c Peripheral venous cannula insertion/management
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Code Status c Urinary catheter initiation/management with urometer
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g Resuscitation status Full Code
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Respiratory
For hypotension and/or lactate > 36 milligram/deciliter
c Resuscitation status Do Not Resuscitate / Do Not
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g
Intubate (allow natural death) despite fluid resuscitation: achieve central venous oxygen
saturation greater than or equal to 70% or mixed venous
c Resuscitation status Partial Code
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Vital Signs oxygen saturation greater than or equal to 65%
Evidence
g Vitals per unit protocol
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For severe sepsis and/or septic shock: maintain inspiratory
c Vital signs every______hours and then
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every_____________ plateau pressure less than 30 cm H20 Evidence
Pulse oximetry Evidence g Oxygen via __________@ _____ to maintain O2 sat at
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c Continuous
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g 90% or greater. Evidence
c Spot q shift and prn
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g Biphasic positive airway pressure (BIPAP) Evidence
Activity c FIO@ _______% Bleed in Oxygen ____LPM Inspiratory
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Pressure ____ Expiratory Pressure_____
g Ambulate with assistance every 8 hours.
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c Biphasic positive airway pressure (BIPAP) Biphasic
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c Bed rest with bedside commode
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g positive airway pressure (BIPAP) with heliox bleedin
c Bed rest
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g Source
c Up ad lib
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g c Continuous positive airway pressure (CPAP) Evidence
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Nursing Orders c Blood gas, arterial now if not done and ________.
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Assessments Evidence
Consider monitoring mean arterial pressure instead of c Blood gas, mixed venous Stat and every 6 hours times
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systolic blood pressure Evidence
For hypotension and/or lactate > 36 milligram/deciliter 4 Evidence
despite fluid resuscitation: achieve central venous c Ventilator settings (Initial settings: Vt 6 cc/kg, maintain
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peak plateau pressures between 25 to 30 cm H2O. FIO2
pressure greater than or equal to 8 mm Hg
Evidence at 100%, AC 14.) Evidence
For severe sepsis and/or septic shock, maintain serum Ventilator settings Evidence
glucose greater than the lower limit of normal but less c Mode _____ Inspiratory Pressure ______ PEEP _____
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FIO2 _____% Rate____ Vt ____ Pressure Support ___
than 150 milligram/deciliter Evidence
FHO Delta P ___ HFO MAP ____
c Assess neurologic status
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c Please record autopeep on vent.
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c Measure ScvO2 continuously if MAP has not responded
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to fluids/pressors. If < 70% do STAT Hb/HCT and
Diet
notify physician. c NPO / NPO except po meds with sips.
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c Glucose, blood, pointofcare measurement every 1
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g c Clear liquids
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hours and STAT if patient shows signs of c Regular diet
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hypoglycemia Evidence c Therapeutic diet ____________.
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c Measure cardiac output
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IV Fluids
Fluid challenge with colloids may be administered at a rate
c Measure central venous pressure (CVP) (hourly)
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Evidence of 300 to 500 milliliters over 30 minutes Evidence
Fluid challenge with crystalloids may be administered at a
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g Measure intake and output Evidence
c Measure weight
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g rate of 500 to 1,000 milliliters over 30 minutes
Interventions Evidence
Consider inserting a central venous catheter Evidence
Order Initiated By: _________________________ Date/Time: _______________
Physician Signature: ________________________ Date/Time: _______________
Released: April 2, 2009
Telephone/Verbal Orders: gc Read Back g
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f c Confirmed
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f Page &p of &P
patient imprint
PHYSICIAN'S ORDER SHEET
Another brand of a generically equivalent product identical in dosage
form and content of active ingredient may be administered unless
indicated.
For hypotension and/or lactate > 36 milligram/deciliter, Antifungal Agents Evidence
deliver an initial minimum of 20 milliliter/kilogram or Reminders
crystalloid (or colloid equivalent) Evidence For septic patients with suspected candidemia,
consider the use of antifungals Evidence
c Sodium Chloride 0.9% @ 1000 cc/hr to and continue to
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maintain MAP >/= 65, CVP 812 cm H2O or total of 40 Echinocandins
mL/kg. Source c Caspofungin/CANCIDAS
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c albumin human 25% IV 25 grams/100 mL
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g c caspofungin /CANCIDAS 70 milligram
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intravenously once initial dose
c Dextrose 5% in Water titrate to maintain BS between 80
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c caspofungin /CANCIDAS 50 milligram
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and 150. Evidence intravenously once a day maintenance dose
c hetastarch in normal saline
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g Polyenes
c Saline lock
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g c amphotericin B /AMPHOTEC 0.5 milligram/kilogram
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Medications intravenously every 24 hours
Antibacterial Agents Triazoles
Reminders c fluconazole /DIFLUCAN 400 milligram intravenously
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Administer broadspectrum antibiotics within 3 hours once a day
for ED admissions and 1 hour for nonED ICU Vasoactive Agents
admissions Evidence Adrenergic Agents Evidence
Aminoglycosides Evidence For hypotension and/or lactate > 36
c tobramycin 7 milligram/kilogram intravenously once
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g milligram/deciliter despite fluid resuscitation,
then pharmacy to do subsequent dosing administer adrenergic vasopressors to maintain mean
BetaLactam/BetaLactamase Inhibitors arterial pressure > 65 mm Hg Source
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g piperacillintazobactam /ZOSYN 4.5 gram c
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g norepinephrine /LEVOPHED 4 microgram/minute
intravenously every 6 hours intravenously increase @ _____ mcg/min 12
mcg/min q15min to maintain MAP > 65 to a max of
Carbapenems Evidence
20 mcg/min.
c imipenemcilastatin /PRIMAXIN 500 milligram
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c phenylephrine /NEOSYNEPHRINE 40
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intravenously every 6 hours
microgram/minute intravenously increase @ 10
c imipenemcilastatin /PRIMAXIN 1 gram
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g mcg/min 1 15 moin to maintain MAP > 65 to a
intravenously every 8 hours maximum of 200 mcg/min
Cephalosporins, 3rdGeneration Evidence c DOBUTamine /DOBUTREX 2.5 microgram/kilogram
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c cefTRIAXone /ROCEPHIN 2 gram intravenously
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g per minute intravenously and titrate to max of 20
once a day mcg/kg/min or ScvO2 > 70%.
Glycopeptides Evidence c DOPamine 5 microgram/kilogram per minute
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c vancomycin /VANCOCIN 25 milligram/kilogram
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g intravenously titrate to a MAP > 65 or max of 20
intravenously once then pharmacy to subsequently mcg/kg/min.
dose c EPINEPHrine _____ microgram/minute (14
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microgram/minute) intravenously titrate to a MAP of
Monobactams Evidence
> 65 mmHg or a max of 10 mcg/min
c aztreonam /AZACTAM 1 gram intravenously every
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8 hours Nonadrenergic Agents Evidence
Nitroimidazoles For septic patients on highdose vasopressor support,
c metroNIDAZOLE /FLAGYL 7.5 milligram/kilogram
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g consider the selective use of nonadrenergic
intravenously every 6 hours vasoactive agents
c vasopressin /PITRESSIN 0.03 unit/minute
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Quinolones Evidence
intravenously
c ciprofloxacin /CIPRO 400 milligram intravenously
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every 8 hours Insulins Evidence
Reminders
c levofloxacin /LEVAQUIN 750 milligram intravenously
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every 24 hours For severe sepsis and/or septic shock, maintain
serum glucose greater than the lower limit of normal
but less than 150 milligram/deciliter Evidence
Order Initiated By: _________________________ Date/Time: _______________
Physician Signature: ________________________ Date/Time: _______________
Released: April 2, 2009
Telephone/Verbal Orders: gc Read Back g
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f c Confirmed
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f Page &p of &P
patient imprint
PHYSICIAN'S ORDER SHEET
Another brand of a generically equivalent product identical in dosage
form and content of active ingredient may be administered unless
indicated.
Shortacting Insulins DVT Prophylaxis
c insulin regular 0.05 to 0.1 unit/kilogram per hour
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g Mechanical methods of prophylaxis should be used
intravenously as a continuous infusion and titrate to primarily in patients who are at high risk of bleeding or
maintain BS between 80 150 as an adjunct to anticoagulantbased prophylaxis.
Antipyretics Consider renal impairment when deciding on doses of
c acetaminophen /TYLENOL _______ orally/nasogastric
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g LMWH, the direct thrombin inhibitors, and other
tube/rectally every 4 hours as needed for fever antithrombotic drugs that are cleared by the kidneys,
greater than 100.4 degrees F. particularly in elderly patients and those who are at high
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g acetaminophen /TYLENOL _______ orally/NG risk for bleeding.
tube/rectally every 4 hours as needed for fever In acutely ill medical patients who have been admitted
greater than 102 degrees F or greater than 100.4 if to the hospital with CHF or severe respiratory disease,
symptomatic. or who are confined to bed and have one or more
Sedatives Evidence adtioanla risk factors, inclujding active CA, previous
For septic patients receiving mechanical ventilation, VTE, sepsis, acute neurologic disease, or inflammatory
consider intermittent bolus or continuous infusion bowel disease, prophylaxis with LDUH or LMWH is
sedation to predefined endpoints recommended. In meidcal patients with risk factors for
c diazepam /VALIUM 2 milligram intravenously every 6
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g VTE in whom there is a contraindication to anticoagulant
hours as needed for sedation prophylaxis, GCS or IPC is recommended.
c diazepam /VALIUM 2 milligram orally 2 times a day as
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g c Early and persistant mobilization
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needed for sedation c Graded compression stockings (1530 mm Hg of
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c LORazepam /ATIVAN _____ mg/kg/hr (0.01 0.1
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g pressure at the ankle)
mg/kg/hr) intravenously as a continuous infusion and c
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g Sequential Compression Device
titrate to Ramsey Sedation Score of _____. (max. 0.1 c CBC every other day starting on day 4 of heparin
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mg/kg/hr) therapy thru day 14 or until Unfractionated
c LORazepam /ATIVAN 1 milligram intravenously every
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g heparin/LMWH is discontinued.
6 hours as needed for sedation LowDose Unfractionated Heparin
c LORazepam /ATIVAN 1 milligram orally 2 times a day
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g c heparin 5,000 unit subcutaneously every 8 hours
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as needed for sedation LowMolecularWeight Heparins
c propofol /DIPRIVAN 5 microgram/kilogram per minute
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g c enoxaparin /LOVENOX 40 milligram subcutaneously
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x 5 minutes and increase by 5 mcg/kg/min. to once a day
Ramsey Sedation Score of _____ (maximum 50
mcg/kg/min)
Stress Ulcer Prophylaxis
Reminders c
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g Initiate Stress Ulcer Prophylaxis Protocol
Avoid routine use of antiinflammatory agents Blood Bank
Evidence Avoid the routine use of fresh frozen plasma to correct
Avoid routine use of antioxidants Evidence laboratory clotting abnormalities Evidence
Avoid routine use of antithrombin III Evidence c Transfusion, platelets Evidence
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Avoid routine use of bicarbonate for patients with pH c Transfusion, red blood cells (RBC), autologous if ScvO2
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greater than or equal to 7.15 Evidence < 70% maintain Hb of 10 g/dL. Evidence
Avoid routine use of erythropoietin Evidence Laboratory
Avoid routine use of granulocyte colonystimulating
c Complete blood cell count with automated white blood
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factor Evidence cell differential
Avoid routine use of neuromuscular blockers Evidence
c Complete blood cell count with manual white blood cell
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Avoid routine use of pentoxifylline Evidence
differential
Avoid routine use of selenium Evidence
Evidence is inconclusive regarding the benefits of IV c
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g Fibrin degradation products
immunoglobulins in patients with sepsis Evidence c Fibrinogen
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IVIG @ 2g/kg for streptococcal severe sepsis may be of g c Ddimer
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benefit. Source c Occult blood, stool
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c Partial thromboplastin time (PTT), activated
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c Prothrombin time (PT) and international normalized ratio
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(INR)
Order Initiated By: _________________________ Date/Time: _______________
Physician Signature: ________________________ Date/Time: _______________
Released: April 2, 2009
Telephone/Verbal Orders: gc Read Back g
d
e
f c Confirmed
d
e
f Page &p of &P
patient imprint
PHYSICIAN'S ORDER SHEET
Another brand of a generically equivalent product identical in dosage
form and content of active ingredient may be administered unless
indicated.
c Basic metabolic panel
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g Patients with severe sepsis or septic shock at risk for
c Comprehensive metabolic panel
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g contrast induced nephropathy. If GFR < 60 mL/min
c Hepatic function panel
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g consider CIN prevention protocol.
c Renal function panel
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g c
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g CT, abdomen and pelvis, with and without contrast
c Thyroid panel
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g Evidence
c Creatine kinase, MB isoenzyme (CKMB)
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g c
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g CT, abdomen and pelvis, with contrast Evidence
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g Creatine kinase, total (CKtotal) c
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g Ultrasound, abdomen Evidence
c TroponinI Evidence
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g c Ultrasound, kidney, bilateral Evidence
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c TroponinT
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g Specialty
c Albumin level, serum
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g Reminders
c Beta human chorionic gonadotropin (betaHCG), urine
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g Consider continuous venovenous hemofiltration rather
qualitative than intermittent hemodialysis Evidence
c Calcium level, serum, ionized
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g Consults
c Calcium level, serum, total
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g c Consult to cardiology
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c Cortisol Evidence
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g c Consult to dietitian, adult
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c Glucose, body fluid Evidence
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g c Consult to gastroenterology
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c Lactate, serum and every 6 hours until normal.
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g c Consult to general surgery Evidence
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Evidence c Consult to infectious diseases
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c Lactate dehydrogenase (LDH), body fluid Evidence
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g c Consult to nephrology Evidence
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c Lactate dehydrogenase (LDH), serum
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g c Consult to neurology
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c Magnesium (Mg) level, serum
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g c Consult to pulmonology Evidence
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c Lipase
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g c Consult to palliative care.
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g pH, body fluid Evidence
Other:____________________________
c Phosphorus level, serum
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c Protein level, total, body fluid Evidence
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c Cell count with differential, body fluid
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Blood cultures should be obtained before administering
antimicrobial therapy Evidence
g Acidfast bacilli (AFB) smear, sputum
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c Culture, acidfast bacilli (AFB), sputum
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c Culture, blood Evidence
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g Culture, catheter tip Evidence
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c Culture, endotracheal aspirate Evidence
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c Culture, pleural fluid Evidence
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c Culture, urine
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c Culture, wound Evidence
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c Gram stain
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c Gram stain, body fluid Evidence
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c Gram stain, endotracheal aspirate Evidence
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c Gram stain, sputum
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c Gram stain, urine
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Diagnostic Tests
g 12lead ECG
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c Echocardiogram, transthoracic Evidence
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c Radiograph, chest, 1 view Evidence
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c Radiograph, abdomen series, with chest, 1 view
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c Radiograph, upper gastrointestinal series and kidney
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ureterbladder (KUB)
Order Initiated By: _________________________ Date/Time: _______________
Physician Signature: ________________________ Date/Time: _______________
Released: April 2, 2009
Telephone/Verbal Orders: gc Read Back g
d
e
f c Confirmed
d
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f Page &p of &P
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