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Forensic Investigation 1227 - AppD

This document outlines various reaction mechanisms for producing several psychoactive substances, including: 1. Amphetamine is produced through reactions of phenyl-2-propanone with formamide, benzaldehyde with nitroethane, and phenyl-2-propanone oxime with hydroxylamine. 2. Methamphetamine is produced through reactions of phenyl-2-propanone with methylamine, and ephedrine with hydrogen iodide or methylamine. 3. Phenyl-2-propanone is produced through esterification and oxidation reactions of phenylacetic acid. 4. MDA and MDMA are produced through reductive amination and substitution reactions

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238 views7 pages

Forensic Investigation 1227 - AppD

This document outlines various reaction mechanisms for producing several psychoactive substances, including: 1. Amphetamine is produced through reactions of phenyl-2-propanone with formamide, benzaldehyde with nitroethane, and phenyl-2-propanone oxime with hydroxylamine. 2. Methamphetamine is produced through reactions of phenyl-2-propanone with methylamine, and ephedrine with hydrogen iodide or methylamine. 3. Phenyl-2-propanone is produced through esterification and oxidation reactions of phenylacetic acid. 4. MDA and MDMA are produced through reductive amination and substitution reactions

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Mike Roller
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Appendix D: Reaction Mechanisms

Amphetamine Reactions
A1
H O
phenyl-2-propanone

O O O H NH2
formamide

NH4 HN H HCl O NH2


amphetamine

ammonium formate

2-formamido-1-phenylpropane

A2
O H
benzaldehyde

NO2 NO2
nitroethane 1-phenyl-2-nitropropene

LiAlH4 NH2
amphetamine

A3
N OH O
phenyl-2-propanone

HONH2
hydroxylamine phenyl-2-propanone oxime

NH2
amphetamine

2004 by CRC Press LLC

A4

O
phenyl-2-propanone

NH3
ammonia

NH2
amphetamine

A5

Cl
allyl chloride benzene

FeCl3
ferric chloride

Cl
1-phenyl-2-chloropropane

NH3

NH2
amphetamine

A6

CH3CN
acetonitrile allylbenzene

HN O
N-acetylamphetamine

HCl

NH2
amphetamine

A7
OH HI
hydriodic acid

NH2
phenylpropanolamine

NH2
amphetamine

Methamphetamine Reactions

M1
H N O
phenyl-2-propanone

CH3NH2
methylamine methamphetamine

2004 by CRC Press LLC

M2
OH H N H2
ephedrine hydrogen methamphetamine

H N

M3
OH H N HI
hydriodic acid ephedrine methamphetamine

H N

M4

Cl
benzyl chloride

Mg
magnesium metal

MgCl
benzyl magnesium chloride

O H
acetaldehyde

CH3NH2
methylamine

N
methylimino ethane

MgCl
benzyl magnesium chloride

N
methylimino ethane

H N

methamphetamine

M5
CH3NH2
or

O H OH N O N H
N-formylmethamphetamine formic acid

H HCl

H N

O O
phenyl-2-propanone

methamphetamine

N-methylformamide

2004 by CRC Press LLC

M6
H N Cl
allyl chloride benzene ferric chloride

FeCl3

Cl
1-phenyl-2-chloropropane

CH3NH2
methylamine methamphetamine

M7
OH Na or Li HN
ephedrine ammonia tetrahydrofuran methamphetamine

H N

Phenylacetone Reactions

P1
OH O
phenylacetic acid

O O

O O
phenyl-2-propanone

acetic anhydride

P2
O CN
benzyl cyanide

CN O ONa
sodium ethoxide

O
-phenylacetoacetonitrile

O
phenyl-2-propanone

ethyl acetate

P3
OH O
phenylacetic acid

Pb(OCOCH3)2
lead acetate

O
phenyl-2-propanone

2004 by CRC Press LLC

P4
OH O
phenylacetic acid

O OH
acetic acid

O
phenyl-2-propanone

P5
O H NO2
nitroethane benzaldehyde 1-phenyl-2-nitropropene

NO2 HCl O
phenyl-2-propanone

P6

OH
phenyl-2-propanol

K2CrO4
potassium dichromate

O
phenyl-2-propanone

P7
O Cl
benzene chloroacetone

O
phenyl-2-propanone

MDA/MDMA Reactions
MD1
O O O
isosafrole 2-formamido-1-(3,4-methylenedioxypheny propane

O O O

H
or

NH2 O NH4

O O HN O HCl O O
MDA

H O

1-(3,4-methylenedioxyphenyl)-2-propane

NH2

2004 by CRC Press LLC

MD2
O O O
piperonal

O NO2
nitroethane

NO2 LiAlH4

O O
MDA

O
3,4-methylenedioxy--methyl--nitrostyrene

NH2

MD3
O O CH3NH2 O
3,4-methylenedioxy P-2-P methylamine

O O HN
MDMA

MD4
O O O O H O CH3NH2
or

OH O O N O
N-formyl-MDMA

HCl H

MDMA

H N

MD5
O O
safrole

HBr

O O Br

CH3NH2 NH3

MDMA MDA

Phencyclidine Analogs

PC1
O H N KCN
or

CN N

MgBr N

NaCN
piperidine cyclohexanone phenyl magnesium bromide 1-piperidinocyclohexane carbonitrile (PCC)

phenylcyclidine (PCP)

2004 by CRC Press LLC

PC2
O H N N
piperidine cyclohexanone 1-(-1-cyclohexenyl)piperidine phenyl magnesium bromide phenylcyclidine (PCP)

MgBr N

MgBr H N CN N
piperidine PCC phenyl magnesium bromide 2-thienyl-1-magnesium bromide PCP

S BrMg
TCP

MgBr O H N
cyclohexanone pyrrolidine PyCC

CN O

N
phenyl magnesium bromide 2-thienyl-1-magnesium bromide PCPy

S N BrMg
TCPy

MgBr H N O
morpholine MCC

CN N O

N
phenyl magnesium bromide 2-thienyl-1-magnesium bromide PCM

O S

S N BrMg
TCM

2004 by CRC Press LLC

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