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Myocardial Infarction Pathophysiology - Schematic Diagram

The document describes the pathophysiology of a myocardial infarction (heart attack). Key points include: - Reduced blood flow to the heart muscle causes anaerobic glycolysis and lactic acid buildup, decreasing contractility and ventricular function. This leads to reduced blood flow to vital organs like the brain, potentially causing loss of consciousness. - Atherosclerosis and thrombosis occur when plaque builds up in coronary arteries, activating platelets and coagulation cascades that enlarge blood clots and further restrict blood flow. - Lack of oxygen and increased carbon dioxide levels cause myocardial cell death, arrhythmias, and stimulation of the sympathetic nervous system with effects like increased heart rate, breathing rate, and vas

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Abi Habiling
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5K views3 pages

Myocardial Infarction Pathophysiology - Schematic Diagram

The document describes the pathophysiology of a myocardial infarction (heart attack). Key points include: - Reduced blood flow to the heart muscle causes anaerobic glycolysis and lactic acid buildup, decreasing contractility and ventricular function. This leads to reduced blood flow to vital organs like the brain, potentially causing loss of consciousness. - Atherosclerosis and thrombosis occur when plaque builds up in coronary arteries, activating platelets and coagulation cascades that enlarge blood clots and further restrict blood flow. - Lack of oxygen and increased carbon dioxide levels cause myocardial cell death, arrhythmias, and stimulation of the sympathetic nervous system with effects like increased heart rate, breathing rate, and vas

Uploaded by

Abi Habiling
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOC, PDF, TXT or read online on Scribd
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Altered Repolarization of the Myocardium

Release of Lysosomal Enzymes

Anaerobic Glycolysis

Lactic Acid Production

Myocardial Irritability Decreased Contractility ANGINA DYSRHYTHMIA Ventricular Function

Preload

CO

Blood Flow to Brain

LOSS OF CONSCIOUSNESS

Enlargement of Thrombus

WEAKNESS/FATIGUE

Occlusive Thrombus

Ischemia of Tissue in Region Supplied by Artery

PALPITATIONS

O2
Coronary Blood Supply Less Than Demand CO2 levels MYOCARDIAL CELL DEATH (NECROSIS) Bld pH

DEEP & LABORED BREATHING

Stimulation of Sympathetic NS

HR

O2 need

Afterload

Epinephrine & Norepinephrine Production BMR

Vasoconstriction

HPN

ARRHYTHMIA

Blood Supply to GI Tract

DIAPHORESIS

N/V

V. PATHOPHYSIOLOGY PATHOPHYSIOLOGY OF MYOCARDIAL INFARCTION

MODIFIABLE FACTORS: Hypertension Smoking Obesity Excessive intake of saturated fats and salt Sedentary lifestyle/physical inactivity

NONMODIFIABLE FACTORS: (+) Family Hx of MI Aging

Change in the Condition of Plaque in the Coronary Artery

Rest Pain

Activation of Platelets Platelet Aggregation, Adhesion, & Buildup of Platelet Mass

Claudication ATHEROSCLEROSIS N/V

THROMBOSIS

Release of Thromboplastin Fainting

Platelet release Thromboxane A2, Serotonin, Platelet Factors 3 & 4

Sweating Coagulation and Vasospasm Cool extremities

Enlargement of Thrombus

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