Oncotarget

Research Papers:

Diagnostic performance of magnetic resonance imaging and 3D endoanal ultrasound in detection, staging and assessment post treatment, in anal cancer

Alfonso Reginelli, Vincenza Granata, Roberta Fusco, Francesco Granata, Daniela Rega, Luca Roberto, Gianluca Pellino, Antonio Rotondo, Francesco Selvaggi, Francesco Izzo, Antonella Petrillo and Roberto Grassi _

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Oncotarget. 2017; 8:22980-22990. https://doi.org/10.18632/oncotarget.14946

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Abstract

Alfonso Reginelli1, Vincenza Granata2, Roberta Fusco2, Francesco Granata3, Daniela Rega4, Luca Roberto1, Gianluca Pellino5, Antonio Rotondo1, Francesco Selvaggi5, Francesco Izzo6, Antonella Petrillo2, Roberto Grassi1

1Department of Internal and Experimental Medicine, Magrassi-Lanzara, Institute of Radiology, Second University of Naples, Naples, Italy

2Department of Diagnostic Imaging, Radiant and Metabolic Therapy, “Istituto Nazionale Tumori Fondazione Giovanni Pascale – IRCCS”, Naples, Italy

3Departement of Civil and Mechanical Engineering, University of Cassino and Southern Lazio, Cassino, Italy

4Department of Colorectal Surgical Oncology, “Istituto Nazionale Tumori Fondazione Giovanni Pascale – IRCCS”, Naples, Italy

5Department of Medical, Surgical, Neurological, Metabolic and Ageing Sciences, Second University of Naples, Naples, Italy

6Department of Surgical Oncology, “Istituto Nazionale Tumori Fondazione Giovanni Pascale – IRCCS”, Naples, Italy

Correspondence to:

Roberta Fusco, email: [email protected]

Keywords: anal cancer, 3D endo anal ultrasound, magnetic resonance imaging, diagnostic performance, post-treatment imaging assessment

Received: October 17, 2016    Accepted: December 27, 2016    Published: February 01, 2017

ABSTRACT

We compared Magnetic Resonance Imaging (MRI) and 3D Endoanal Ultrasound (EAUS) imaging performance to confirm anal carcinoma and to monitor treatment response.

58 patients with anal cancer were retrospectively enrolled. All patients underwent clinical examination, anoscopic examination; EAUS and contrast-enhanced MRI study before and after treatment. Four radiologists evaluated the presence of lesions, using a 4-point confidence scale, features of the lesion and nodes on EAUS images, T1-weighted (T1-W), T2-weighted (T2-W) and diffusion-weighted images (DWI) signal intensity (SI), the apparent diffusion coefficient (ADC) map for nodes and lesion, as well as enhancement pattern during dynamic MRI were assessed.

All lesions were detected by EAUS while MRI detected 93.1% of anal cancer. MRI showed a good correlation with EAUS, anoscopy and clinical examination. The residual tissue not showed significant difference in EAUS assessment and T2-W SI in pre and post treatment. We found significant difference in dynamic study, in SI of DWI, in ADC map and values among responder’s patients in pre and post treatment. The neoplastic nodes were hypoecoic on EAUS, with hyperintense signal on T2-W sequences and hypointense signal on T1-W. The neoplastic nodes showed SI on DWI sequences and ADC value similar to anal cancer. We found significant difference in nodes status in pre and post therapy on DWI data.

3D EAUS and MRI are accurate techniques in anal cancer staging, although EAUS is more accurate than MRI for T1 stage. MRI allows correct detection of neoplastic nodes and can properly stratify patients into responders or non responders.


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