Impaired Epstein-Barr Virus-Specific Neutralizing Antibody Response during Acute Infectious Mononucleosis Is Coincident with Global B-Cell Dysfunction

Archana Panikkar; Corey Smith; Andrew Hislop; Nick Tellam; Vijayendra Dasari; Kristin A Hogquist; Michelle Wykes; Denis J Moss; Alan Rickinson; Henry H Balfour Jr; Rajiv Khanna

doi:10.1128/JVI.01293-15

Impaired Epstein-Barr Virus-Specific Neutralizing Antibody Response during Acute Infectious Mononucleosis Is Coincident with Global B-Cell Dysfunction

J Virol. 2015 Sep;89(17):9137-41. doi: 10.1128/JVI.01293-15. Epub 2015 Jun 24.

Authors

Affiliations

¹ QIMR Berghofer Centre for Immunotherapy and Vaccine Development, Tumour Immunology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia School of Medicine, University of Queensland, Brisbane, QLD, Australia.
² QIMR Berghofer Centre for Immunotherapy and Vaccine Development, Tumour Immunology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia [email protected] [email protected].
³ School of Cancer Sciences, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom.
⁴ QIMR Berghofer Centre for Immunotherapy and Vaccine Development, Tumour Immunology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
⁵ Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
⁶ Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, Minnesota, USA Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, USA.

Abstract

Here we present evidence for previously unappreciated B-cell immune dysregulation during acute Epstein-Barr virus (EBV)-associated infectious mononucleosis (IM). Longitudinal analyses revealed that patients with acute IM have undetectable EBV-specific neutralizing antibodies and gp350-specific B-cell responses, which were associated with a significant reduction in memory B cells and no evidence of circulating antibody-secreting cells. These observations correlate with dysregulation of tumor necrosis factor family members BAFF and APRIL and increased expression of FAS on circulating B cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Neutralizing / immunology*
Antibodies, Viral / immunology*
B-Cell Activating Factor / immunology
B-Lymphocytes / immunology*
B-Lymphocytes / virology
CD8-Positive T-Lymphocytes / immunology
Capsid Proteins / immunology
Epstein-Barr Virus Infections / immunology
Epstein-Barr Virus Infections / virology
Herpesvirus 4, Human / immunology*
Humans
Immunologic Memory / immunology
Infectious Mononucleosis / immunology*
Infectious Mononucleosis / virology
Lymphocyte Activation / immunology
Tumor Necrosis Factor Ligand Superfamily Member 13 / immunology
Viral Matrix Proteins / immunology
fas Receptor / metabolism

Substances

Antibodies, Neutralizing
Antibodies, Viral
B-Cell Activating Factor
Capsid Proteins
EBV-associated membrane antigen, Epstein-Barr virus
TNFSF13B protein, human
Tumor Necrosis Factor Ligand Superfamily Member 13
Viral Matrix Proteins
fas Receptor

Grants and funding

15032/CRUK_/Cancer Research UK/United Kingdom