Abstract
Two new dimeric xanthone O-glycosides, puniceasides A (1) and B (2), a new trimeric O-glycoside, puniceaside C (3), and two new trimeric C-glycosides, puniceasides D (4) and E (5), together with 12 known xanthones were isolated from the entire plant of Swertia punicea. The structures of 1-5 were determined by HRESIMS and NMR spectroscopic methods. Compounds 2, 6, and 7 exhibited potent neuroprotective activity against H(2)O(2)-induced PC12 cell damage.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology*
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Glycosides / chemistry
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Glycosides / isolation & purification*
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Glycosides / pharmacology*
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Hydrogen Peroxide / pharmacology
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Molecular Structure
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Neuroprotective Agents / chemistry
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Neuroprotective Agents / isolation & purification*
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Neuroprotective Agents / pharmacology*
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Nuclear Magnetic Resonance, Biomolecular
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PC12 Cells
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Rats
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Swertia / chemistry*
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Xanthones / chemistry
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Xanthones / isolation & purification*
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Xanthones / pharmacology*
Substances
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Drugs, Chinese Herbal
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Glycosides
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Neuroprotective Agents
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Xanthones
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puniceaside A
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puniceaside B
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Hydrogen Peroxide