Abstract
T helper type 17 (Th17) cells are a distinct lineage of T cells that produce the effector molecules IL-17, IL-17F, IL-21, and IL-22. Although the role of Th17 cells in autoimmunity is well documented, there is growing evidence that the Th17 lineage and other interleukin (IL)-17-producing cells are critical for host defense against bacterial, fungal, and viral infections at mucosal surfaces. Here we summarize recent progress in our understanding of the function of IL-17-producing cells as a bridge between innate and adaptive immunity against infectious diseases at the mucosa.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Cell Lineage
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Humans
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Immunity, Innate / immunology*
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Immunologic Deficiency Syndromes / immunology
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Immunotherapy
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Infections / immunology*
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Interleukins / metabolism
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Lymphocyte Cooperation / immunology*
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Mice
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Mice, Knockout
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Models, Immunological
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Mucous Membrane / immunology*
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Receptors, Interleukin-17 / deficiency
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Receptors, Interleukin-17 / physiology
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Signal Transduction
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T-Lymphocyte Subsets / immunology*
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T-Lymphocyte Subsets / metabolism
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T-Lymphocytes, Helper-Inducer / immunology*
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T-Lymphocytes, Helper-Inducer / metabolism
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Tumor Necrosis Factor-alpha / metabolism
Substances
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IL17RA protein, human
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Il17ra protein, mouse
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Interleukins
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Receptors, Interleukin-17
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Tumor Necrosis Factor-alpha