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Insights into Computational Drug Repurposing for Neurodegenerative Disease
Manish Paranjpe, Ali Taubes, Marina Sirota
Trends Pharmacol Sci. Author manuscript; available in PMC 2020 Aug 1.
Published in final edited form as: Trends Pharmacol Sci. 2019 Aug; 40(8): 565–576. Published online 2019 Jul 17. doi: 10.1016/j.tips.2019.06.003
PMCID:
PMC6771436
Abstract Article PDF–589K

Is Cited by the Following 32 Articles in this Archive:

Brain organoid as a model to study the role of mitochondria in neurodevelopmental disorders: achievements and weaknesses
Raquel Coronel, Enrique García-Moreno, Emilio Siendones, Maria J. Barrero, Beatriz Martínez-Delgado, Carlos Santos-Ocaña, Isabel Liste, M. V. Cascajo-Almenara
Front Cell Neurosci. 2024; 18: 1403734. Published online 2024 Jun 24. doi: 10.3389/fncel.2024.1403734
PMCID:
PMC11228165
Abstract Article PDF–3.4M
Tackling neurodegeneration in vitro with omics: a path towards new targets and drugs
Caterina Carraro, Jessica V. Montgomery, Julien Klimmt, Dominik Paquet, Joachim L. Schultze, Marc D. Beyer
Front Mol Neurosci. 2024; 17: 1414886. Published online 2024 Jun 17. doi: 10.3389/fnmol.2024.1414886
PMCID:
PMC11215216
Abstract Article PDF–1.2M
Indole-Based Compounds in the Development of Anti-Neurodegenerative Agents
Elisabetta Barresi, Emma Baglini, Valeria Poggetti, Jacopo Castagnoli, Doralice Giorgini, Silvia Salerno, Sabrina Taliani, Federico Da Settimo
Molecules. 2024 May; 29(9): 2127. Published online 2024 May 3. doi: 10.3390/molecules29092127
PMCID:
PMC11085553
Abstract Article PDF–22M
Artificial intelligence and open science in discovery of disease-modifying medicines for Alzheimer’s disease
Feixiong Cheng, Fei Wang, Jian Tang, Yadi Zhou, Zhimin Fu, Pengyue Zhang, Jonathan L. Haines, James B. Leverenz, Li Gan, Jianying Hu, Michal Rosen-Zvi, Andrew A. Pieper, Jeffrey Cummings
Cell Rep Med. 2024 Feb 20; 5(2): 101379. Published online 2024 Feb 20. doi: 10.1016/j.xcrm.2023.101379
PMCID:
PMC10897520
Abstract Article PDF–3.6M
The contemporary nexus of medicines security and bioprospecting: a future perspective for prioritizing the patient
Geoffrey A. Cordell
Nat Prod Bioprospect. 2024 Dec; 14(1): 11. Published online 2024 Jan 25. doi: 10.1007/s13659-024-00431-5
PMCID:
PMC10811317
Abstract Article PDF–1.2M
The evolving role of extracellular vesicles (exosomes) as biomarkers in traumatic brain injury: Clinical perspectives and therapeutic implications
Naushad Ahmad Khan, Mohammad Asim, Ayman El-Menyar, Kabir H. Biswas, Sandro Rizoli, Hassan Al-Thani
Front Aging Neurosci. 2022; 14: 933434. Published online 2022 Oct 6. doi: 10.3389/fnagi.2022.933434
PMCID:
PMC9584168
Abstract Article PDF–1.4M
Impact of the Renin-Angiotensin System on the Pathogeny and Pharmacotherapeutics of Neurodegenerative Diseases
Walther Bild, Alexandru Vasincu, Răzvan-Nicolae Rusu, Daniela-Carmen Ababei, Aurelian Bogdan Stana, Gabriela Dumitrița Stanciu, Bogdan Savu, Veronica Bild
Biomolecules. 2022 Oct; 12(10): 1429. Published online 2022 Oct 6. doi: 10.3390/biom12101429
PMCID:
PMC9599929
Abstract Article PDF–1.0M
The Time Sequence of Gene Expression Changes after Spinal Cord Injury
Seyoung Mun, Kyudong Han, Jung Keun Hyun
Cells. 2022 Jul; 11(14): 2236. Published online 2022 Jul 18. doi: 10.3390/cells11142236
PMCID:
PMC9324287
Abstract Article PDF–4.0M
A comprehensive review of artificial intelligence and network based approaches to drug repurposing in Covid-19
Faheem Ahmed, Afaque Manzoor Soomro, Abdul Rahim Chethikkattuveli Salih, Anupama Samantasinghar, Arun Asif, In Suk Kang, Kyung Hyun Choi
Biomed Pharmacother. 2022 Sep; 153: 113350. Published online 2022 Jun 28. doi: 10.1016/j.biopha.2022.113350
PMCID:
PMC9236981
Abstract Article PDF–3.9M
Computational drug repurposing based on electronic health records: a scoping review
Nansu Zong, Andrew Wen, Sungrim Moon, Sunyang Fu, Liwei Wang, Yiqing Zhao, Yue Yu, Ming Huang, Yanshan Wang, Gang Zheng, Michelle M. Mielke, James R. Cerhan, Hongfang Liu
NPJ Digit Med. 2022; 5: 77. Published online 2022 Jun 14. doi: 10.1038/s41746-022-00617-6
PMCID:
PMC9198008
Abstract Article PDF–1.0M
Novel use of FDA-approved drugs identified by cluster analysis of behavioral profiles
Sara Tucker Edmister, Thaís Del Rosario Hernández, Rahma Ibrahim, Cameron A. Brown, Sayali V. Gore, Rohit Kakodkar, Jill A. Kreiling, Robbert Creton
Sci Rep. 2022; 12: 6120. Published online 2022 Apr 21. doi: 10.1038/s41598-022-10133-y
PMCID:
PMC9023506
Abstract Article PDF–4.6M
A Study on Methodologies of Drug Repositioning Using Biomedical Big Data: A Focus on Diabetes Mellitus
Suehyun Lee, Seongwoo Jeon, Hun-Sung Kim
Endocrinol Metab (Seoul) 2022 Apr; 37(2): 195–207. Published online 2022 Apr 13. doi: 10.3803/EnM.2022.1404
PMCID:
PMC9081315
Abstract Article PDF–336K
Deficiency of autism-related Scn2a gene in mice disrupts sleep patterns and circadian rhythms
Zhixiong Ma, Muriel Eaton, Yushuang Liu, Jingliang Zhang, Xiaoling Chen, Xinyu Tu, Yiqiang Shi, Zhefu Que, Kyle Wettschurack, Zaiyang Zhang, Riyi Shi, Yueyi Chen, Adam Kimbrough, Nadia A. Lanman, Leah Schust, Zhuo Huang, Yang Yang
Neurobiol Dis. Author manuscript; available in PMC 2023 Jun 15.
Published in final edited form as: Neurobiol Dis. 2022 Jun 15; 168: 105690. Published online 2022 Mar 14. doi: 10.1016/j.nbd.2022.105690
PMCID:
PMC9018617
Abstract Article PDF–2.0M
An integrated chemo-informatics and in vitro experimental approach repurposes acarbose as a post-ischemic neuro-protectant
Jyotirekha Das, Fayaz Shaik Mahammad, Rajanikant Golgodu Krishnamurthy
3 Biotech. 2022 Mar; 12(3): 71. Published online 2022 Feb 15. doi: 10.1007/s13205-022-03130-5
PMCID:
PMC8847516
Abstract Article PDF–8.2M
Multi-Targets: An Unconventional Drug Development Strategy for Alzheimer’s Disease
Cheng-Xin Gong, Chun-Ling Dai, Fei Liu, Khalid Iqbal
Front Aging Neurosci. 2022; 14: 837649. Published online 2022 Feb 9. doi: 10.3389/fnagi.2022.837649
PMCID:
PMC8864545
Abstract Article PDF–527K
Applied machine learning in Alzheimer's disease research: omics, imaging, and clinical data
Ziyi Li, Xiaoqian Jiang, Yizhuo Wang, Yejin Kim
Emerg Top Life Sci. 2021 Dec 21; 5(6): 765–777. Published online 2021 Dec 9. doi: 10.1042/ETLS20210249
PMCID:
PMC8786302
Abstract Article PDF–1.2M
Artificial intelligence for COVID-19: battling the pandemic with computational intelligence
Zhenxing Xu, Chang Su, Yunyu Xiao, Fei Wang
Intell Med. 2022 Feb; 2(1): 13–29. Published online 2021 Oct 21. doi: 10.1016/j.imed.2021.09.001
PMCID:
PMC8529224
Abstract Article PDF–1.7M
Sex-Specific Cross Tissue Meta-Analysis Identifies Immune Dysregulation in Women With Alzheimer’s Disease
Manish D. Paranjpe, Stella Belonwu, Jason K. Wang, Tomiko Oskotsky, Aarzu Gupta, Alice Taubes, Kelly A. Zalocusky, Ishan Paranjpe, Benjamin S. Glicksberg, Yadong Huang, Marina Sirota
Front Aging Neurosci. 2021; 13: 735611. Published online 2021 Sep 30. doi: 10.3389/fnagi.2021.735611
PMCID:
PMC8515049
Abstract Article PDF–5.0M
Advances in the computational landscape for repurposed drugs against COVID-19
Illya Aronskyy, Yosef Masoudi-Sobhanzadeh, Antonio Cappuccio, Elena Zaslavsky
Drug Discov Today. 2021 Dec; 26(12): 2800–2815. Published online 2021 Jul 30. doi: 10.1016/j.drudis.2021.07.026
PMCID:
PMC8323501
Abstract Article PDF–813K
Reimagining Innovation Amid the COVID-19 Pandemic: Insights From the WISH Innovation Programme
Maha El Akoum, Mahmoud El Achi
Front Public Health. 2021; 9: 678768. Published online 2021 Jun 7. doi: 10.3389/fpubh.2021.678768
PMCID:
PMC8215261
Abstract Article PDF–178K
Diagnostic and Therapeutic Potential of Exosomal MicroRNAs for Neurodegenerative Diseases
Miao He, Hai-nan Zhang, Zhen-chu Tang, Shu-guang Gao
Neural Plast. 2021; 2021: 8884642. Published online 2021 May 16. doi: 10.1155/2021/8884642
PMCID:
PMC8143892
Abstract Article PDF–632K
Sex, ApoE4 and Alzheimer’s disease: rethinking drug discovery in the era of precision medicine
Manish D. Paranjpe, Jason K Wang, Yun Zhou
Neural Regen Res. 2021 Sep; 16(9): 1764–1765. Published online 2021 Jan 25. doi: 10.4103/1673-5374.306070
PMCID:
PMC8328780
Article PDF–463K
Perspective insights of repurposing the pleiotropic efficacy of statins in neurodegenerative disorders: An expository appraisal
Aditi Bhat, Harshita Dalvi, Harsha Jain, Nagarjun Rangaraj, Shashi Bala Singh, Saurabh Srivastava
Curr Res Pharmacol Drug Discov. 2021; 2: 100012. Published online 2020 Dec 31. doi: 10.1016/j.crphar.2020.100012
PMCID:
PMC8663947
Abstract Article PDF–1.1M
Framework for identifying drug repurposing candidates from observational healthcare data
Michal Ozery-Flato, Yaara Goldschmidt, Oded Shaham, Sivan Ravid, Chen Yanover
JAMIA Open. 2020 Dec; 3(4): 536–544. Published online 2020 Dec 31. doi: 10.1093/jamiaopen/ooaa048
PMCID:
PMC7886555
Abstract Article PDF–829K
The Application of Artificial Intelligence in the Genetic Study of Alzheimer’s Disease
Rohan Mishra, Bin Li
Aging Dis. 2020 Dec; 11(6): 1567–1584. Published online 2020 Dec 1. doi: 10.14336/AD.2020.0312
PMCID:
PMC7673858
Abstract Article PDF–463K
Recent Advances and Future Perspectives in the Development of Therapeutic Approaches for Neurodegenerative Diseases
Melissa Bowerman
Brain Sci. 2020 Sep; 10(9): 633. Published online 2020 Sep 11. doi: 10.3390/brainsci10090633
PMCID:
PMC7565049
Article PDF–177K
Molecular Profiling in Sarcoidosis
Nicholas K. Arger, Brian O’Connor, Laura L. Koth
Curr Opin Pulm Med. Author manuscript; available in PMC 2021 Sep 1.
Published in final edited form as: Curr Opin Pulm Med. 2020 Sep; 26(5): 562–567. doi: 10.1097/MCP.0000000000000716
PMCID:
PMC7899149
Abstract Article PDF–319K
Repurposed agents in the Alzheimer’s disease drug development pipeline
Justin Bauzon, Garam Lee, Jeffrey Cummings
Alzheimers Res Ther. 2020; 12: 98. Published online 2020 Aug 17. doi: 10.1186/s13195-020-00662-x
Correction in:
Alzheimers Res Ther. 2023; 15: 139.
PMCID:
PMC7433208
Abstract Article PDF–1.8M
Digital Pharmaceutical Sciences
Safa A. Damiati
AAPS PharmSciTech. 2020 Aug; 21(6): 206. Published online 2020 Jul 26. doi: 10.1208/s12249-020-01747-4
PMCID:
PMC7382958
Abstract Article PDF–734K
cando.py: Open Source Software for Predictive Bioanalytics of Large Scale Drug–Protein–Disease Data
William Mangione, Zackary Falls, Gaurav Chopra, Ram Samudrala
J Chem Inf Model. Author manuscript; available in PMC 2021 May 5.
Published in final edited form as: J Chem Inf Model. 2020 Sep 28; 60(9): 4131–4136. Published online 2020 Jun 26. doi: 10.1021/acs.jcim.0c00110
PMCID:
PMC8098009
Abstract Article PDF–522K