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Germline-encoded neutralization of a Staphylococcus aureus virulence factor by the human antibody repertoire
Yik Andy Yeung, Davide Foletti, Xiaodi Deng, Yasmina Abdiche, Pavel Strop, Jacob Glanville, Steven Pitts, Kevin Lindquist, Purnima D. Sundar, Marina Sirota, Adela Hasa-Moreno, Amber Pham, Jody Melton Witt, Irene Ni, Jaume Pons, David Shelton, Arvind Rajpal, Javier Chaparro-Riggers
Nat Commun. 2016; 7: 13376. Published online 2016 Nov 18. doi: 10.1038/ncomms13376
PMCID:
PMC5120205
Abstract Article PDF–1.2M

Is Cited by the Following 27 Articles in this Archive:

Identification of small molecules affecting the interaction between human hemoglobin and Staphylococcus aureus IsdB hemophore
Monica Cozzi, Mariacristina Failla, Eleonora Gianquinto, Sandra Kovachka, Valeria Buoli Comani, Carlotta Compari, Omar De Bei, Roberta Giaccari, Francesco Marchesani, Marialaura Marchetti, Luca Ronda, Barbara Rolando, Massimo Baroni, Gabriele Cruciani, Barbara Campanini, Stefano Bettati, Serena Faggiano, Loretta Lazzarato, Francesca Spyrakis
Sci Rep. 2024; 14: 8272. Published online 2024 Apr 9. doi: 10.1038/s41598-024-55931-8
PMCID:
PMC11003968
Abstract Article PDF–4.6M
Enhancers within the immunoglobulin V-gene region orchestrate chromatin topology and regulate V gene rearrangement frequency to shape the B cell receptor repertoire specificities
E. Mauricio Barajas-Mora, Ann J. Feeney
J Immunol. Author manuscript; available in PMC 2024 Dec 1.
Published in final edited form as: J Immunol. 2023 Dec 1; 211(11): 1613–1622. doi: 10.4049/jimmunol.2300261
PMCID:
PMC10662671
Currently embargoed: Free in PMC on Dec 1, 2024; PubMed
Widespread impact of immunoglobulin V-gene allelic polymorphisms on antibody reactivity
Meng Yuan, Ziqi Feng, Huibin Lv, Natalie So, Ivana R. Shen, Timothy J.C. Tan, Qi Wen Teo, Wenhao O. Ouyang, Logan Talmage, Ian A. Wilson, Nicholas C. Wu
Cell Rep. 2023 Oct 31; 42(10): 113194. Published online 2023 Sep 30. doi: 10.1016/j.celrep.2023.113194
PMCID:
PMC10636607
Abstract Article PDF–5.3M
Germline-encoded specificities and the predictability of the B cell response
Marcos C. Vieira, Anna-Karin E. Palm, Christopher T. Stamper, Micah E. Tepora, Khoa D. Nguyen, Tho D. Pham, Scott D. Boyd, Patrick C. Wilson, Sarah Cobey
PLoS Pathog. 2023 Aug; 19(8): e1011603. Published online 2023 Aug 25. doi: 10.1371/journal.ppat.1011603
PMCID:
PMC10484431
Abstract Article PDF–2.4M
Genetic variation in the immunoglobulin heavy chain locus shapes the human antibody repertoire
Oscar L. Rodriguez, Yana Safonova, Catherine A. Silver, Kaitlyn Shields, William S. Gibson, Justin T. Kos, David Tieri, Hanzhong Ke, Katherine J. L. Jackson, Scott D. Boyd, Melissa L. Smith, Wayne A. Marasco, Corey T. Watson
Nat Commun. 2023; 14: 4419. Published online 2023 Jul 21. doi: 10.1038/s41467-023-40070-x
PMCID:
PMC10362067
Abstract Article PDF–2.8M
Widespread impact of immunoglobulin V gene allelic polymorphisms on antibody reactivity
Meng Yuan, Ziqi Feng, Huibin Lv, Natalie So, Ivana R. Shen, Timothy J.C. Tan, Qi WenTeo, Wenhao O. Ouyang, Logan Talmage, Ian A. Wilson, Nicholas C. Wu
Version 1. bioRxiv. Preprint. 2023 Jun 7. doi: 10.1101/2023.06.06.543969
Published in:
Cell Rep. 2023 Oct 31; 42(10): 113194.
PMCID:
PMC10274783
Abstract Article PDF–9.7M
ImmunoTyper-SR: A Computational Approach for Genotyping Immunoglobulin Heavy Chain Variable Genes using Short Read Data
Michael K.B. Ford, Ananth Hari, Oscar Rodriguez, Junyan Xu, Justin Lack, Cihan Oguz, Yu Zhang, Andrew J. Oler, Ottavia M. Delmonte, Sarah E. Weber, Mary Magliocco, Jason Barnett, Sandhya Xirasagar, Smilee Samuel, Luisa Imberti, Paolo Bonfanti, Andrea Biondi, Clifton L. Dalgard, Stephen Chanock, Lindsey B. Rosen, Steven M. Holland, Helen C. Su, Luigi D. Notarangelo, NIAID COVID Consortium, Uzi Vishkin, Corey T. Watson, S. Cenk Sahinalp
Cell Syst. Author manuscript; available in PMC 2023 Oct 19.
Published in final edited form as: Cell Syst. 2022 Oct 19; 13(10): 808–816.e5. doi: 10.1016/j.cels.2022.08.008
PMCID:
PMC10084889
Abstract Article PDF–1.0M
B cells in the balance: Offsetting self-reactivity avoidance with protection against foreign
Clara Young, Angelica W. Y. Lau, Deborah L. Burnett
Front Immunol. 2022; 13: 951385. Published online 2022 Jul 25. doi: 10.3389/fimmu.2022.951385
PMCID:
PMC9364820
Abstract Article PDF–602K
Pandemic, Epidemic, Endemic: B Cell Repertoire Analysis Reveals Unique Anti-Viral Responses to SARS-CoV-2, Ebola and Respiratory Syncytial Virus
Alexander Stewart, Emma Sinclair, Joseph Chi-Fung Ng, Joselli Silva O’Hare, Audrey Page, Ilaria Serangeli, Christian Margreitter, Federica Orsenigo, Katherine Longman, Cecile Frampas, Catia Costa, Holly-May Lewis, Nora Kasar, Bryan Wu, David Kipling, Peter JM Openshaw, Christopher Chiu, J Kenneth Baillie, Janet T. Scott, Malcolm G. Semple, Melanie J. Bailey, Franca Fraternali, Deborah K. Dunn-Walters
Front Immunol. 2022; 13: 807104. Published online 2022 May 3. doi: 10.3389/fimmu.2022.807104
PMCID:
PMC9111746
Abstract Article PDF–7.0M
Potential Therapeutic Targets for Combination Antibody Therapy against Pseudomonas aeruginosa Infections
Luke L. Proctor, Whitney L. Ward, Conner S. Roggy, Alexandra G. Koontz, Katie M. Clark, Alyssa P. Quinn, Meredith Schroeder, Amanda E. Brooks, James M. Small, Francina D. Towne, Benjamin D. Brooks
Antibiotics (Basel) 2021 Dec; 10(12): 1530. Published online 2021 Dec 14. doi: 10.3390/antibiotics10121530
PMCID:
PMC8698887
Abstract Article PDF–3.1M
Immunoglobulin germline gene variation and its impact on human disease
Ivana Mikocziova, Victor Greiff, Ludvig M. Sollid
Genes Immun. 2021; 22(4): 205–217. Published online 2021 Jun 26. doi: 10.1038/s41435-021-00145-5
PMCID:
PMC8234759
Abstract Article PDF–2.6M
Igh Locus Polymorphism May Dictate Topological Chromatin Conformation and V Gene Usage in the Ig Repertoire
Amy L. Kenter, Corey T. Watson, Jan-Hendrik Spille
Front Immunol. 2021; 12: 682589. Published online 2021 May 18. doi: 10.3389/fimmu.2021.682589
PMCID:
PMC8167033
Abstract Article PDF–664K
Resident vs nonresident multipotent mesenchymal stromal cell interactions with B lymphocytes result in disparate outcomes
Wei Lee, Li‐Tzu Wang, Men‐Luh Yen, Pei‐Ju Hsu, Yu‐Wei Lee, Ko‐Jiunn Liu, Kuo‐I Lin, Yu‐Wen Su, Huey‐Kang Sytwu, B. Linju Yen
Stem Cells Transl Med. 2021 May; 10(5): 711–724. Published online 2021 Jan 28. doi: 10.1002/sctm.20-0289
PMCID:
PMC8046079
Abstract Article PDF–4.2M
Rapid exploration of the epitope coverage produced by an Ebola survivor to guide the discovery of therapeutic antibody cocktails
Tom Z Yuan, Ana G Lujan Hernandez, Erica Keane, Qiang Liu, Fumiko Axelrod, Shweta Kailasan, Madeleine Noonan-Shueh, Mohammad Javad Aman, Aaron K Sato, Yasmina N Abdiche
Antib Ther. 2020 Jul; 3(3): 167–178. Published online 2020 Aug 1. doi: 10.1093/abt/tbaa016
PMCID:
PMC7454256
Abstract Article PDF–3.4M
Iron Metabolism at the Interface between Host and Pathogen: From Nutritional Immunity to Antibacterial Development
Marialaura Marchetti, Omar De Bei, Stefano Bettati, Barbara Campanini, Sandra Kovachka, Eleonora Gianquinto, Francesca Spyrakis, Luca Ronda
Int J Mol Sci. 2020 Mar; 21(6): 2145. Published online 2020 Mar 20. doi: 10.3390/ijms21062145
PMCID:
PMC7139808
Abstract Article PDF–4.6M
Restricted epitope specificity determined by variable region germline segment pairing in rodent antibody repertoires
Yi-Chun Hsiao, Ying-Jiun J. Chen, Leonard D. Goldstein, Jia Wu, Zhonghua Lin, Kellen Schneider, Subhra Chaudhuri, Aju Antony, Kanika Bajaj Pahuja, Zora Modrusan, Dhaya Seshasayee, Somasekar Seshagiri, Isidro Hötzel
MAbs. 2020 Jan-Dec; 12(1): 1722541. Published online 2020 Feb 10. doi: 10.1080/19420862.2020.1722541
PMCID:
PMC7039645
Abstract Article PDF–5.6M
An Optimized Full-Length FLT3/CD3 Bispecific Antibody Demonstrates Potent Anti-leukemia Activity and Reversible Hematological Toxicity
Yik Andy Yeung, Veena Krishnamoorthy, Danielle Dettling, Cesar Sommer, Kris Poulsen, Irene Ni, Amber Pham, Wei Chen, Sindy Liao-Chan, Kevin Lindquist, S. Michael Chin, Allison Given Chunyk, Wenyue Hu, Barbra Sasu, Javier Chaparro-Riggers, Ivana Djuretic
Mol Ther. 2020 Mar 4; 28(3): 889–900. Published online 2020 Jan 14. doi: 10.1016/j.ymthe.2019.12.014
PMCID:
PMC7054815
Abstract Article PDF–2.3M
Human VH1-69 Gene-Encoded Human Monoclonal Antibodies against Staphylococcus aureus IsdB Use at Least Three Distinct Modes of Binding To Inhibit Bacterial Growth and Pathogenesis
Monique R. Bennett, Jinhui Dong, Robin G. Bombardi, Cinque Soto, Helen M. Parrington, Rachel S. Nargi, Clara T. Schoeder, Marcus B. Nagel, Kevin L. Schey, Jens Meiler, Eric P. Skaar, James E. Crowe, Jr.
mBio. 2019 Sep-Oct; 10(5): e02473-19. Published online 2019 Oct 22. doi: 10.1128/mBio.02473-19
PMCID:
PMC6805997
Abstract Article PDF–2.5M
Essential Domain-Dependent Roles Within Soluble IgG for in vivo Superantigen Properties of Staphylococcal Protein A: Resolving the B-Cell Superantigen Paradox
Alejandro J. Ulloa-Morales, Carl S. Goodyear, Gregg J. Silverman
Front Immunol. 2018; 9: 2011. Published online 2018 Sep 19. doi: 10.3389/fimmu.2018.02011
PMCID:
PMC6156153
Abstract Article PDF–1.9M
Hierarchy of human IgG recognition within the Staphylococcus aureus immunome
Emily E. Radke, Stuart M. Brown, Adam J. Pelzek, Yi Fulmer, David N. Hernandez, Victor J. Torres, Isaac P. Thomsen, William K. Chiang, Andy O. Miller, Bo Shopsin, Gregg J. Silverman
Sci Rep. 2018; 8: 13296. Published online 2018 Sep 5. doi: 10.1038/s41598-018-31424-3
PMCID:
PMC6125462
Abstract Article PDF–1.6M
Human Memory B Cells Targeting Staphylococcus aureus Exotoxins Are Prevalent with Skin and Soft Tissue Infection
Adam J. Pelzek, Bo Shopsin, Emily E. Radke, Kayan Tam, Beatrix M. Ueberheide, David Fenyö, Stuart M. Brown, Qianhao Li, Ada Rubin, Yi Fulmer, William K. Chiang, David N. Hernandez, Hanane El Bannoudi, William E. Sause, Alexis Sommerfield, Isaac P. Thomsen, Andy O. Miller, Victor J. Torres, Gregg J. Silverman
mBio. 2018 Mar-Apr; 9(2): e02125-17. Published online 2018 Mar 13. doi: 10.1128/mBio.02125-17
PMCID:
PMC5850327
Abstract Article PDF–4.5M
Structure–function analyses of a stereotypic rheumatoid factor unravel the structural basis for germline-encoded antibody autoreactivity
Mitsunori Shiroishi, Yuji Ito, Kenta Shimokawa, Jae Man Lee, Takahiro Kusakabe, Tadashi Ueda
J Biol Chem. 2018 May 4; 293(18): 7008–7016. Published online 2018 Mar 9. doi: 10.1074/jbc.M117.814475
PMCID:
PMC5936827
Abstract Article PDF–1.9M
Crystal structure reveals vaccine elicited bactericidal human antibody targeting a conserved epitope on meningococcal fHbp
Jacinto López-Sagaseta, Peter T. Beernink, Federica Bianchi, Laura Santini, Elisabetta Frigimelica, Alexander H. Lucas, Mariagrazia Pizza, Matthew J. Bottomley
Nat Commun. 2018; 9: 528. Published online 2018 Feb 6. doi: 10.1038/s41467-018-02827-7
PMCID:
PMC5802752
Abstract Article PDF–1.8M
In-Depth Analysis of Human Neonatal and Adult IgM Antibody Repertoires
Binbin Hong, Yanling Wu, Wei Li, Xun Wang, Yumei Wen, Shibo Jiang, Dimiter S. Dimitrov, Tianlei Ying
Front Immunol. 2018; 9: 128. Published online 2018 Feb 5. doi: 10.3389/fimmu.2018.00128
PMCID:
PMC5807330
Abstract Article PDF–1.6M
Infants Infected with Respiratory Syncytial Virus Generate Potent Neutralizing Antibodies that Lack Somatic Hypermutation
Eileen Goodwin, Morgan S. A. Gilman, Daniel Wrapp, Man Chen, Joan O. Ngwuta, Syed M. Moin, Patricia Bai, Arvind Sivasubramanian, Ruth I. Connor, Peter F. Wright, Barney S. Graham, Jason S. McLellan, Laura M. Walker
Immunity. Author manuscript; available in PMC 2018 Jun 18.
Published in final edited form as: Immunity. 2018 Feb 20; 48(2): 339–349.e5. Published online 2018 Feb 3. doi: 10.1016/j.immuni.2018.01.005
PMCID:
PMC6005179
Abstract Article PDF–1.0M
Structural Determination of the Broadly Reactive Anti-IGHV1-69 Anti-idiotypic Antibody G6 and Its Idiotope
Yuval Avnir, Kristina L. Prachanronarong, Zhen Zhang, Shurong Hou, Eric C. Peterson, Jianhua Sui, Hatem Zayed, Vinodh B. Kurella, Andrew T. McGuire, Leonidas Stamatatos, Brendan J. Hilbert, Markus-Frederik Bohn, Timothy F. Kowalik, Jeffrey D. Jensen, Robert W. Finberg, Jennifer P. Wang, Margaret Goodall, Roy Jefferis, Quan Zhu, Nese Kurt Yilmaz, Celia A. Schiffer, Wayne A. Marasco
Cell Rep. 2017 Dec 12; 21(11): 3243–3255. Published online 2017 Dec 12. doi: 10.1016/j.celrep.2017.11.056
PMCID:
PMC7185437
Abstract Article PDF–4.3M
The Individual and Population Genetics of Antibody Immunity
Corey T. Watson, Jacob Glanville, Wayne A. Marasco
Trends Immunol. 2017 Jul; 38(7): 459–470. Published online 2017 May 20. doi: 10.1016/j.it.2017.04.003
PMCID:
PMC5656258
Abstract Article PDF–1.7M