Tempus AI’s Post

“NCCN Guidelines Thyroid Carcinoma” More recently, modern genomic classifiers have shown promise for diagnosis of Hürthle cell-containing specimens, with sensitivity values ranging from 88.9% to 92.9% and specificity values ranging from 58.8% to 69.3% for detecting Hürthle cell cancers. 89,90 Molecular diagnostic testing may include multigene assays or individual mutational analysis. In addition to their utility in diagnostics, molecular markers are beneficial for making decisions about targeted therapy options for advanced disease and for informing eligibility for some clinical trials. In addition, the presence of some mutations may have prognostic importance. #genetest #EGFR #KRAS #NTRK #ALT #BRAF #ALK #RET #qPCR

Introducing Bio-Rad's Celselect Slides™ Validated Antibodies for rare cell & circulating tumor cell (CTC) enumeration, in tandem with Celselect Slides Enumeration Stain Kits. Specifically designed for detection of CTC surface markers, these antibodies enhance tumor heterogeneity and disease progression studies. Our Genesis Cell Isolation System captures diverse CTCs for downstream analysis or on-slide immunostaining, facilitating enumeration & identification. Learn more at https://ow.ly/K19g50R1LSq #BioRad #CancerResearch #CTCenumeration #RareCellEnumeration #AntibodiesValidation

My latest research on #Reproduction_Genetics has just been published with #SpringerNature in Cell Death and Disease journal. In this work we show that upregulated innate immune response due to low Androgen Receptor signaling could play a protective role against raising genotoxic stress in individuals with dysgenetic gonads and idiopathic nonobstructive azoospermia, therefore potentially diminishing the risk of DNA mutagenesis and germ cell tumorigenesis, but simultaneously compromising gonadal and germ cell differentiation. A better understanding of molecular mechanisms of infertility will help to propose new therapeutical treatments and facilitate early germ cell tumor diagnostics, thus avoiding prophylactic gonadectomy. Read here: https://lnkd.in/edi_Zffy

ANGLE is pleased to share a new publication, conducted by researchers at the University of Birmingham, who used the Parsortix® system to capture circulating tumor cells (CTCs) for multiplexed proteomic analysis of CTCs in head and neck squamous cell carcinoma (HNSCC).   This study provides new insight into the molecular heterogeneity of HNSCC, with 41 key biomarkers including immune checkpoint proteins, PD-L1, CTLA4 and CD39 being evaluated, and offers the potential for more precise and personalized treatment strategies.   It also demonstrates the feasibility of mass cytometry, a powerful technique widely used for single cell analysis, for the comprehensive characterization of CTCs in HNSCC patients.   Read the full press release here: https://lnkd.in/dQbCbgyJ   For Research Use Only. Not For Use In Diagnostic Procedures.   #ANGLEplc #Parsortix #liquidbiopsy #CTC  

By harnessing our Azymetric™ technology to screen multiple trispecific formats, geometries and paratope affinities for optimization of T cell activation, we developed two novel approaches to build differentiated and next generation Trispecific T Cell Engagers. Trispecific T Cell Engagers with costimulation (TriTCE Co-stim) provides T cells with signal 1 and signal 2 for enhanced T cell activity and fitness for therapeutic applications in solid tumors with low T cell infiltration, while our Trispecific T Cell Engages with Checkpoint Inhibition (TriTCE CPI) combines redirected T cell killing with immune checkpoint modulation to enhance activity and therapeutic applications for T cells engagers in immunosuppressed solid tumors. Learn more about our Trispecific T Cell Engagers: https://lnkd.in/ergdaKfM

Regulatory T cell research has been underway since the identification of a unique T cell subset with suppressive function in 1969. In 1995 CD25 was identified as a marker for these unique T cells, and in 2003 FoxP3 was identified as the transcription factor driving and maintaining their phenotype and function. Extensive research continues as new regulatory T cells subsets are identified and novel therapeutic approaches for not only autoimmune diseases, but cancer and other illnesses are examined. If regulatory T cell research is in your purview, check out the recent additions to the Bethyl Laboratories, Inc. | Fortis Life Sciences catalog: mCD39 (A700-285) and two new FoxP3 (A700-281, A700-282) antibodies. #treg #regulatorytcells #lifesciences #autoimmunity #antibodies #research #monoclonalantibodies #antibodyresearch graphic created with BioRender.com

Is universal, guideline-concordant, rapid genomic testing crucial? Initial treatment before receipt of genomic test results yields significantly inferior outcomes (RWD from For patients harboring AODs in advanced NSCLC). #PrecisionMedicine #LungCancer

🌟 Dive into our latest article, "Tetraspanin CD81: A Key Receptor for Hepatitis C Virus (HCV), an Established Exosome Marker, a Promising Target for Antiviral or Antitumor Research". Uncover the pivotal role of CD81's structure and functions in combating diseases like HCV and cancer. Explore its mechanisms in viral infections, impact on cell morphology, and influence in tumor progression. Discover the exciting prospects of CD81 in varied disease research and its potential in clinical advancements. 🚀 Read more: https://bit.ly/41RaMx2 #CD81 #HepatitisCResearch #CancerResearch #MedicalScience #Biotech #CUSABIO