Molecular Devices’ Post

Shan D., our Vice President of Strategy and Innovation, is passionate about leveraging collaborative partnerships to drive 3D biology adoption industrywide and advocating for diversity earlier in drug development. Check out his latest published perspectives on these topics and more: https://ow.ly/kjrS50SkVKO. 📰 Organoids Stand Out as Stand Ins in Drug Development: https://lnkd.in/e4tg8TSs 📰 New Collaboration Finds a Match Between Liver-Derived Organoids and Automated Screening Technologies: https://lnkd.in/gnG2zf6e 📰 The Benefits of AI and Automation in the Cell Culture Process: https://lnkd.in/gKbEDCU2 📰 The Importance of Introducing Diversity Earlier in Drug Development: https://lnkd.in/g4vDZc9A #3dbiology #3dcellculture #organoids #drugdiscovery #drugscreening #drugdevelopment #diseasemodeling #labautomation #ai #machinelearning #deeplearning #highcontentimaging #highcontentscreening #scienceandtechnology #pharma #geneeditting #cellculture #pdo #imageanalysis

𝐒𝐮𝐫𝐟𝐚𝐜𝐞 𝐏𝐥𝐚𝐬𝐦𝐨𝐧 𝐑𝐞𝐬𝐨𝐧𝐚𝐧𝐜𝐞 (𝐒𝐏𝐑) plays a crucial role in monitoring biomolecule affinity binding and screening for druggable compounds, fragment based screening, High-Throughput Screening (HTS), Proteomics Research & Cellular Analysis and Cell-Based Detection. It enables high-sensitivity real-time measurement of interactions without the use of labels, allowing for more sensitive measurement of target analytes and the use of native biomolecules appropriate for biologically relevant methods. At o2h discovery we have harnessed cutting-edge SPR technology-Biacore T200 to advance Fragment-Based Drug Discovery (FBDD) screening. Read more about advantages and advancement in SPR technology - https://lnkd.in/d_XkZuSH #o2hdiscovery #drugdiscovery #surfaceplasmaresonance #SPRTechnology #FBDD #biology #HTS #proteomics #cellular #analysis

Shawn Nielsen Alvarado, Ph.D., our Drug Discovery Sales Representative, introduces prospective customers to our high-content imaging and screening systems to advance their research. Check out her latest published perspectives on these topics and more: https://ow.ly/iZNB50SSwnr. 📷 Achieving Accurate Raw Images with High-Content Screening: https://lnkd.in/gF87iDxy #3dbiology #3dcellculture #organoids #drugdiscovery #drugscreening #drugdevelopment #diseasemodeling #labautomation #ai #machinelearning #deeplearning #highcontentimaging #highcontentscreening #scienceandtechnology #pharma #geneeditting #cellculture #pdo #imageanalysis

Interested in using high content to screen? Check out the articles below and message me with questions!

⭐Publication Spotlight⭐     Dueñas ME, Peltier-Heap RE, Leveridge M, Annan RS, Büttner FH & Trost M. Advances in high-throughput mass spectrometry in drug discovery. EMBO Mol Med 15: e14850 (2023)  https://lnkd.in/dM78wG-V    In this review article, Dueñas et al. make the case for high-throughput mass spectrometry as a uniquely powerful drug discovery tool, describing recent technological advances that have made these assays "cheaper, faster, and more physiologically relevant" than competitors. The authors provide a clear and cogent overview of MS technologies and highlight the RapidFire-MS platform (invented by our team!) as a key innovation in the development of high-throughput mass spectrometry,      We were also excited by their discussion of Affinity Selection Mass Spectrometry (ASMS), one of Momentum's cornerstone assays. The authors establish the value of ASMS as a label-free, direct detection screening approach that requires minimal assay development and "can accommodate targets where very little knowledge of protein function or structure exists." They also discuss potential challenges of this approach – reminding us how fortunate we are that Momentum's team has the deep knowledge and experience necessary to perform these assays successfully and efficiently.      Check out the link above to read the full article! And if you think that high-throughput mass spectrometry could be the answer to your assay challenges, contact us to learn more: https://lnkd.in/e6GFCEvW 

"The next generation of therapeutic molecules feel tantalizingly within reach" A great article from C&EN Benjamin Plackett on the ongoing efforts towards macrocyclic peptides in drug discovery. 👉 https://lnkd.in/eqm7fQFe The complexity of macrocycles has been a limiting factor in their commercial viability for therapeutics. But research and technological developments are helping to overcome these challenges. At Optibrium, we're excited to develop cutting-edge 3D modelling software enabling scientists to accurately predict the conformations and properties of macrocycles. Our BioPharmics platform enables users to apply biophysical constraints to help model very large peptidic macrocycles. It includes both structure-based and ligand-based machine learning approaches. We've had a number of exciting case studies recently published, showcasing accelerated macrocycle discovery, including state-of-the-art active learning approaches. If you want to hear more, you can watch our webinar recording from a few weeks ago, all about macrocyclic lead optimisation 👉 https://lnkd.in/eQe-Cq7b #Macrocycles #DrugOptimisation #DrugDiscovery #3DModelling

To accelerate drug discovery, miniaturization of organic synthesis is essential. Check out our paper on "High-Throughput Miniaturized Synthesis of PROTAC-Like Molecules". 💊 Our approach enables on-chip PROTAC library synthesis with UV-induced release of target molecules into individual nanoliter droplets for on-chip biological screenings. We synthesized 132 novel PROTAC-like molecules, characterized them with MALDI-MS imaging and tested in a cell-based on-chip assay. Fantastic collaboration with Prof. Dr. Carsten Hopf at CeMOS - Center for Mass Spectrometry and Optical Spectroscopy 🚀 Great example of what can be done using Aquarray droplet microarrays. https://lnkd.in/efzvVnXJ PROTACs, or Proteolysis Targeting Chimeras, represent a novel therapeutic approach that enables the degradation of proteins utilizing the intracellular protein degradation system. PROTACS are heterobifunctional molecules designed to label target proteins for ubiquitination and subsequent degradation by the proteasome machinery, thereby offering a unique approach to protein degradation-based therapy. Although the cell-based assay did not discover new efficient PROTACs, this work lays the foundation for the miniaturized integrated on-chip drug discovery process, starting from combinatorial synthesis on-chip up to cell-based screenings using the SAME droplet microarray. This integration is highly challenging yet indispensable for accelerating drug discovery. Congratulations to Maximilian Seifermann, Ye Tian, Anna Popova, Janne Jasmin Wiedmann, Julius Höpfner, Marius Brehm, Stefan Schmidt, Charlotte Sauerland, Liana Bauer and all other fantastic collaborators! Karlsruhe Institute of Technology (KIT) #drugdiscovery #miniaturization #PROTACs

𝗦𝗶𝗻𝗴𝗹𝗲 𝗖𝗲𝗹𝗹 𝗔𝗻𝗮𝗹𝘆𝘀𝗶𝘀 𝗠𝗮𝗿𝗸𝗲𝘁 𝟮𝟬𝟮𝟰-𝟮𝟬𝟯𝟭. 𝗚𝗹𝗼𝗯𝗮𝗹 𝗥𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗥𝗲𝗽𝗼𝗿𝘁 The research report provides a detailed overview of the Single Cell Analysis industry, including the development of its industry chain and market status across biopharmaceutical and biotechnology companies, as well as cell banks and IVF centers, focusing on technologies like flow cytometry and mass spectrometry. It analyzes key enterprises and market trends, along with cutting-edge technologies and patents. The report highlights regional market dynamics, noting steady growth in North America and Europe due to government initiatives and rising consumer awareness, while Asia-Pacific, particularly China, leads with strong domestic demand and supportive policies. The Single Cell Analysis market is categorized by type and application, with projections from 2024 to 2031 providing forecasts on consumption values, assisting stakeholders in identifying promising niche markets. 𝗧𝗼 𝗞𝗻𝗼𝘄 𝗚𝗹𝗼𝗯𝗮𝗹 𝗦𝗰𝗼𝗽𝗲 𝗮𝗻𝗱 𝗗𝗲𝗺𝗮𝗻𝗱 𝗼𝗳 𝗦𝗶𝗻𝗴𝗹𝗲 𝗖𝗲𝗹𝗹 𝗔𝗻𝗮𝗹𝘆𝘀𝗶𝘀 𝗠𝗮𝗿𝗸𝗲𝘁. 𝗥𝗲𝗾𝘂𝗲𝘀𝘁 𝗳𝗼𝗿 𝗦𝗮𝗺𝗽𝗹𝗲 𝗣𝗗𝗙: https://lnkd.in/eMZ34KXH *𝗕𝘆 𝗧𝘆𝗽𝗲: Flow Cytometry, Mass Spectrometry, Microscopy, Next-Generation Sequencing (NGS), Others *𝗕𝘆 𝗔𝗽𝗽𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻:  Biopharmaceutical and Biotechnology Companies, Cell Banks and IVF Centers, Hospitals and Diagnostics Laboratories, Research & Academic Laboratories, Others *𝗕𝘆 𝗥𝗲𝗴𝗶𝗼𝗻: North America, Europe, Asia-Pacific, South America, Middle East & Africa *𝗕𝘆 𝗞𝗲𝘆 𝗣𝗹𝗮𝘆𝗲𝗿𝘀: BD Medical Group, Medtronic, Merck Group, Agilent Technologies, Stryker, Thermo Fisher Scientific, Beckman Coulter Diagnostics, GE HealthCare, Miltenyi Biotec, NanoString Technologies, Inc., Celgene, QIAGEN, Illumina #singlecellanalysis #genomics #cellbiology #biotechnology #singlecell #geneticsequencing #singlecellgenomics #molecularbiology #cellularbiology #biomedicalresearch #genomeresearch #cellsequencing #bioinformatics #singlecelltranscriptomics #biotech #cellanalysis #cellularanalysis #lifesciences #singlecellbiology #cellomics #cellbasedresearch #singlecelltechnologies #genomicsresearch #bioresearch #genetictesting #cellscience #cellularimaging #precisionmedicine #genomicdata #biologicalresearch

Have you ever wondered how RNA cargo size affects the efficiency of encapsulation?💊 How do lipid nanoparticles compare to other delivery vehicles, such as viral vectors? This following recent study has the answers! Snippet Highlights: 🌏 The article discusses the use of analytical tools such as dynamic light scattering, transmission electron microscopy, and UV-Vis spectroscopy to analyze benchmark formulations of lipid nanoparticles. 🌍 The study found that the size and distribution of the nanoparticles were affected by various factors such as lipid composition, encapsulation method, and RNA cargo size. 🌎 The researchers also observed that the encapsulation efficiency of the RNA cargo was dependent on the type of lipid used, with certain lipids showing higher efficiency than others. 🌏 They also discovered that the commonly used dynamic light scattering (DLS) method for nanoparticle characterization has limitations and may not accurately capture the true size distribution. 🌎 The team proposed a new method for nanoparticle characterization that combines DLS with asymmetric flow field-flow fractionation (AF4) to improve accuracy and reliability. 🎯 Take-Home message: Understanding the characterization of lipid nanoparticles is crucial for the successful encapsulation of RNA cargo, which has significant implications in the development of RNA-based therapeutics. ------ Do you like our Snippet Phriday sessions? Recommend, ♻️Repost, if you find it useful. TechnoPharmaSphere LLC. Biopharm Consultant and CRO https://lnkd.in/d_q6PUF https://lnkd.in/gy2zmS5m ⏩P.S. Stay tuned for the detailed insights about Lipid nanoparticles and related content! #Biopharmaceuticals #DrugDelivery #Nanotechnology #Biologics #Innovation #SnippetPhriday