Crystal Pharmatech’s Post

Leveraging cutting-edge technology, Shimadzu’s QTOF Mass Spectrometers offer high mass accuracy and user-friendly maintenance. Customizable add-on equipment caters to your specific needs in characterization of biologics.   Discover how Shimadzu’s QTOF Mass Spectrometers can empower your research in these areas: - Analyzing post-translational modifications (PTMs) - Conducting mass analysis of monoclonal antibodies (mAbs) - Identifying and characterizing oligonucleotide impurities

𝗩𝗶𝘀𝗶𝘁 𝗨𝘀! American Chemical Society (ACS) New Orleans Spring Meeting (Booth #3029), and attend our workshop on March 20 (3:30 pm | Room 5 - Hall B) on 𝘚𝘵𝘳𝘶𝘤𝘵𝘶𝘳𝘦-𝘉𝘢𝘴𝘦𝘥 𝘋𝘳𝘶𝘨 𝘋𝘦𝘴𝘪𝘨𝘯: 𝘋𝘰𝘤𝘬𝘪𝘯𝘨, 𝘍𝘳𝘢𝘨𝘮𝘦𝘯𝘵 𝘙𝘦𝘱𝘭𝘢𝘤𝘦𝘮𝘦𝘯𝘵, 3𝘋 𝘝𝘪𝘳𝘵𝘶𝘢𝘭 𝘓𝘪𝘣𝘳𝘢𝘳𝘺 𝘌𝘯𝘶𝘮𝘦𝘳𝘢𝘵𝘪𝘰𝘯 𝘢𝘯𝘥 𝘗𝘳𝘰𝘵𝘦𝘪𝘯 𝘍𝘢𝘮𝘪𝘭𝘺 𝘈𝘯𝘢𝘭𝘺𝘴𝘪𝘴 | Register at https://bit.ly/43jFIqq #ACSSpring2024 𝗪𝗼𝗿𝗸𝘀𝗵𝗼𝗽: March 20, 2024 | 3:30 pm | Room 5 - Hall B, New Orleans Ernest N. Morial Convention Center 𝗧𝗶𝘁𝗹𝗲: Structure-Based Drug Design: Docking, Fragment Replacement, 3D Virtual Library Enumeration and Protein Family Analysis 𝗧𝗼𝗽𝗶𝗰𝘀: Pharmacophore Modeling / Docking / Fragment-based Design / Scaffold Replacement / R-Group Screening / Project Search / Protein-Ligand Interaction Fingerprints (PLIF) 𝗗𝗲𝘀𝗰𝗿𝗶𝗽𝘁𝗶𝗼𝗻: The workshop describes SBDD workflows in drug discovery projects and encompasses a range of topics from pharmacophore query generation to protein-ligand interaction fingerprints. More specifically, the workshop will cover the application of pharmacophores in the context of protein-ligand docking, scaffold replacement and R-group screening. A method for querying a 3D project database will also be presented along with the generation and analysis of protein-ligand interaction fingerprints (PLIF). #compchem #medchem #drugdiscovery #drugdesign

🌟 We are thrilled to announce that our company is a proud sponsor of the 12th Peptoid Summit 🌟 💡 Peptoids have been making significant strides as potential therapeutics and self-assembling polymers for material development. With their unique structural properties and versatility of side chains, peptoids offer incredible potential in drug discovery and material sciences. 👨🔬 At Gyros Protein Technologies, we understand the importance of supporting scientific advancements, which is why we are committed to providing cutting-edge instrumentation that addresses the synthetic challenges posed by peptoids. ⭐ Our flexible software, induction heating technology, improved chemical compatibility, and inert experimental conditions enable the synthesis of challenging peptoids, leading to higher purity and efficiency. 👉 We proudly showcase how our instrumentation facilitates the parallel synthesis of high-purity peptoids and peptoid analogs, including the self-assembling diblock peptoid and the opioid receptor agonist peptoid-peptide hybrid. 🙌 We are eagerly looking forward to connecting with fellow innovators and researchers at the Peptoid Summit. #purepep #peptoid #synthesis

Our first TwistedNano publication is out in The Journal of Chemical Physics! We theoretically explore the potential of metal-based plasmonic structures for surface-enhanced chiroptical sensing of dilute chiral drug solutions. We find that surface plasmon resonances in the considered systems amplify the circular dichroism differential absorption of solvated reparixin, a pharmaceutical molecule currently used in clinical studies for patients with community-acquired pneumonia, including COVID-19 and acute respiratory distress syndrome. Our calculations reveal that a ≈ 20 circular-dichroism differential absorption enhancement factor can be attained. These findings hold significant importance for the advancement of the project. You can find below the publication link and a brief explanatory video. Furthermore, in the supplementary information of the publication we provide a user-friendly function to extract the bi-anisotropic optical constants of reparixin calculated from first principles. https://lnkd.in/dt_nmXaW https://lnkd.in/dQnc2a9G #TwistedNano #reparixin #nanophotonics #chiraldrugs

It is known that Biolayer interferometry (BLI) is an optical biosensor method for real-time, label-free analysis of biomolecular interactions (kinetic analyses, analyte detection and quantitation). However, not everyone knows BLI can support diverse activities of drug discovery and development, ranging from compound library screening, structure-activity relationship and selectivity analyses of small-molecule drug leads, to cell line development, optimization, characterization and QC. Today, I was surprised to find that the performance of Gator Bio’s biosensors has been improved to a new level which has once again broken the record. #BLI #GatorBio #LabelFree #BiomolecularInteraction #Kinetic #Quantitation #Detection #DrugDiscovery #Screening #CLD #QC

NMR spectra might be hard to understand in some cases, specially if you are working with large molecules. Let the Elucidation Assistant of ORCOD LabBook Pro tell you which signals should every 1H of your molecule display on 1D and 2D NMR experiments, so that you can just check whether they exist and thus confirm the molecular structure. Try ORCOD LabBook Pro now for FREE in https://lnkd.in/dh9FEpUv #orcodchemistry #chemistry #nmr #organicchemistry #drugdiscovery #pharma

🚀 Discover Innovative Drug Discovery Approach! Optimizing molecules for drug discovery is often a tedious and costly process. However, by implementing automation and miniaturization directly into biological assays, we can accelerate synthesis, save expensive reagents, and eliminate the need for extensive single-compound purification and handling. This innovative approach is commonly known as plate-based chemistry or direct-to-biology. In addition to classical small molecules, this method has been successfully applied to new modalities like PROTACs. At the upcoming EFMC-ISMC 2024, where we will showcase a proof-of-principle case study demonstrating automated reaction miniaturization of amide couplings, followed by direct biological readouts of unpurified reaction mixtures. 🌐Curious about the details? Visit our poster and schedule a meeting with our team for an in-depth discussion -> https://lnkd.in/excR7WYi #PlateBasedChemistry #LifeScienceChemistry #DrugDiscovery #EFMCISMC2024 #NUVISAN #ScienceCRO

How are amorphous solid dispersions (ASD) characterized? Because ASDs exist in high-energy and unstable states, it is imperative to understand their behavior under various conditions. This includes: 🔹 XRPD 🔹 Thermal Analysis 🔹 Microscopy Methods 🔹 Additional Methods Crystal Pharmatech and Crystal Formulation Services (CFS) experts have outlined various examples of how ASDs are characterized in the newest edition of the ASD White Paper Series. Learn more at: https://lnkd.in/dgmWRjVp #CrystalPharmatech #CrystalFormulationServices #CFS #ASD #CMC #Biotech #DrugDevelopment #Research #Technology #API #CRO #CDMO

Accelerate small molecule development with our Rapid mSAS® Screens Ensure your small molecule therapeutic enters pre-clinical or clinical studies with the best possible profile using our mSAS® Small Molecule Screens. Our advanced screening processes consistently produce pure, highly crystalline, and free-flowing powders, setting the stage for success. Crystec offers three rapid screening options: 1. Generating Stable, Crystalline Samples Whether producing the first crystalline sample, eliminating residual solvents or impurities, or even providing a nucleation seed, our mSAS® screens ensure you are working with pure, stable, crystalline material. 2. Identifying Alternative Polymorphs Leverage the power of mSAS® to uncover new solid-state forms early on. Our screens typically generate a range of polymorphs, including those unique to the supercritical environment, enabling you to select the most suitable form for your studies. 3. Enhancing Powder Quality for Better Bioavailability Improve the performance of your therapeutic with our high-quality powders. Expect low impurity levels, narrow particle size distribution, and minimized agglomeration, all contributing to superior dissolution and enhanced delivery. For more details, reach out to our Business Development Manager, Zeesharn Farook, at [email protected]. #crystecpharma #screening #preclinicalresearch #drugdevelopment #msas #smallmolecules #crystallisation #polymorph

During drug discovery, the identification of bioactive compounds is crucial. High-throughput screening (HTS) is commonly used for this purpose, with libraries containing thousands or millions of compounds. However, confirming the identity of these candidate compounds is equally important. While traditional techniques such as LC-MS/UV and NMR spectroscopy are precise, they are not efficient or cost-effective in a high-throughput setting. Here's where the Echo® MS+ system with ZenoTOF 7600 system comes in. This technical note demonstrates the rapid identification of 45 compounds using both polarities in less than 4 minutes. This means that drug discovery campaigns can now quickly and accurately confirm the identities of their candidate compounds while keeping costs low. #drugdiscovery #highthroughputscreening #EchoMS #ZenoTOF