Caris Life Sciences’ Post

We are glad to announce the publication of Pathfast 0/2 hour high sensitivity troponin algorithm evaluation by the Swiss research group led by Prof. Müller of the University Hospital Basel . In addition to the 0/1 hour protocol, which has been mentioned in the ESC guidelines for Pathfast since 2020, the new algorithm represents an important milestone for high sensitivity troponin diagnostics with Pathfast. Thus, it could be demonstrated that the POC hs-cTnI-PATHFAST assay allows rapid and effective rule-out and rule-in of NSTEMI using both a 0/1h- and a 0/2h-algorithm with high NPV/sensitivity for rule-out and high PPV/specificity for rule-in. Learn more about Pathfast POC Immunoanalyzer: https://lnkd.in/dfcsvPyN #poc #cardiac #emergency

Eyetube caught up with Russ Van Gelder, MD, PhD, at #AAO2023 earlier this month to learn more about KIO-301 and the findings from our ABACUS study in retinitis pigmentosa "KIO-301 is a small molecule photoswitch, which can confer on neurons, the ability to fire in light and silence in dark. This is a potential way to reverse blindness in patients with advanced outer-retinal degeneration in retinitis pigmentosa and potentially in age-related macular degeneration. In patients with no light or bare light perception, they gained the ability to detect light or detect light better.” Kiora looks forward to initiating our Phase 2 confirmatory studies in #RetinitisPigmentosa, #choroideremia and #Stargardtdisease. https://lnkd.in/g_h7f8kc

Agree...the large BMT centers in India are reluctant to undertake such studies...the media and public too is against clinical trials...we just follow guidelines from the West...the leadership of BMT centers must convince the public of the necessity of such clinical trials...that is responsible leadership...profits as the sole motive cannot be leadership...only Suparno Chakrabarti is bold enough to generate and publish Indian data...others simply either follow western data or do not publish...of course there is no dearth of huge and lavish conferences with international faculty which basically are marketing exercises for attracting patients to hospitals.

🔦 See your cells in a new light! 🔬 HoloMonitor M4FL's #holography & #fluorescence combination gives you even more data on your cells than before ... 🤫 and stunning time-lapse movies! Image right inside the incubator for maintaining a relevant cell environment and achieving relevant #researchresults. For this #livecell #timelapse, we treated A549 cells with 7.5µM Shikonin and imaged for 48h. Cell death is monitored in real-time! (We used here the CellTox™ Green Cytotoxicity Assay). #holographymeetsfluorescence #livecellimaging #QPI #GFP #fluorescence #cellresearch #application #celldeath

Following a highly successful treatment of BPH – enlargement of the prostate gland – using pulsed electromagnetic field (PEMF) therapy in dogs, the Parsemus Foundation supported a small clinical trial in men to see if the positive results translated to humans. The results of these studies offer hope for a non-invasive, drug-free treatment for enlarged prostate. Click here to read more: https://lnkd.in/gdv6ybZk #BPH #enlargedprostate #PEMF

Learn how cryofluorescence tomography (CFT) provided unbiased insights into the biodistribution of AAV7 compared to AAV9, and uncovered transduction in atypical organs for potential new target indications: https://bit.ly/47TsrWY #genetherapy #preclinicalresearch #CFT

✨ You asked, Lunaphore delivered! Signal amplification for protein is working beautifully on the COMET✨ Check out this poster + reach out for more details! https://lnkd.in/eJCVCy-T #ultrahighplexprotein #spatialbiology

New paper alert! Congratulations to Haguy Wolfenson and Lidan Shi on this great work! It was great collaborating to support your findings with some theoretical models, excellent work done by Hamidreza Jafarinia at MERLN Institute for Technology-Inspired Regenerative Medicine! https://lnkd.in/eAqpDXsT Highlights: • pYAP-Y357 accumulates at small adhesions on soft matrices and leads to apoptosis • YAP phosphorylation by c-Abl and Src drives the apoptotic decision • Failure of adhesion reinforcement determines pYAP-Y357 accumulation • Cellular decisions to undergo apoptosis or grow can be switched by myosin inhibition

Enhanced recovery of urinary small extracellular vesicles using differential ultracentrifugation: in their latest study, Carmen Jeronimo at Instituto Português de Oncologia do Porto (IPO-Porto) and collaborators aimed to optimise an ultracentrifugation protocol to reduce processing time and improve the yield of small extracellular vesicles. By testing different ultracentrifugation durations at 200,000g, they discovered that 48 minutes and 60 minutes significantly increased SEV recovery compared to the standard 25 minutes https://lnkd.in/esVxmGT4 Overall, their optimised UC protocol demonstrated greater time efficiency and recovered more SEVs than Exoquick-TC, while also preserving RNA quality and quantity and reducing SEV separation time. An article also authored by Ana Teixeira Marques, Sara Monteiro Reis, Diana Montezuma Felizardo, Catarina Lourenço, Miguel Carlos Oliveira, Vera Constâncio, José Pedro Sequeira, Carina Carvalho‑Maia, Rui Freitas, Elena Martens-Uzunovaa, M. Helena Vasconcelos and Rui Henrique #extracellularvesicles #exosomes #isolation #ultracentifugation #Vesiculab