BioLamina’s Post

👁 "Vision” Created by Organoids Discovering the Future of Retinal Health: Advances from the Frontiers of Biotechnology The paper "Multimodal Spatiotemporal Phenotyping of Human Retinal Organoid Development" published in Nature Biotechnology utilizes advanced imaging and genetic techniques to study retinal organoids derived from human pluripotent stem cells. It emphasizes the use of iterative indirect immunofluorescence (4i), single-cell RNA sequencing (scRNA-seq), and ATAC sequencing (scATAC-seq) to explore cellular dynamics and gene regulatory networks crucial for retinal development. These insights help model retinal diseases and potentially guide the development of targeted therapies, showcasing the potential of organoids in medical research and disease modeling. If you want to know more details, please click the link below! https://lnkd.in/gVXNX6Ba

This webinar will be hosted live on August 29th at 01:00 UTC and available on-demand. If you're a lab professional or a Genetics researcher, these topics will be of interest to you. -Optimizing pre-analytical processing for reliable saliva samples -Assessing quality control measures, including DNA yield, integrity, and quality -Common challenges and solutions for working with oral samples, including comparing collection methods, DNA extraction best practices, compatibility with common extraction methods, preparing extracted DNA for downstream applications, comparability to blood samples, and manual and automated extraction workflows and efficiencies -Stem Cell Transplantation: Maximizing HLA-Match Accuracy Using Saliva-Derived DNA, including goals of the Malaysian Stem Cell Registry, populations, protocols, data collection and analysis, sample type rationale, and how sample collection methods affect Registry outcomes https://lnkd.in/ezv-NJ9x

As we finish up the week, I’m reflecting on the Nobel Prize awarded to Victor Ambros and Gary Ruvkun for their discovery of micro-RNAs (miRNAs). Their work highlights how these tiny molecules regulate gene expression, paving the way for innovative therapies for conditions like cancer, heart disease, and genetic disorders. As companies like Novo Nordisk explore miRNA-based drugs, we can expect a surge in biopharmaceutical advancements that could reshape treatment protocols and drive economic growth in the sector. This shows how important it is to keep investing in molecular research, which helps us understand biology better and opens up new paths for drug development and personalized medicine. Exciting times lie ahead for healthcare and the biopharma industry! #NobelPrize #MicroRNA #Biotech #Biopharma

New “GPS nanoparticle” delivers a genetic punch to the protein implicated in tumor spread. A newly developed "GPS nanoparticle" injected intravenously can home in on cancer cells to deliver a genetic punch to the protein implicated in tumor growth and spread, according to researchers from Penn State. They tested their approach in human cell lines and in mice to effectively knock down a cancer-causing gene, reporting that the technique may potentially offer a more precise and effective treatment for notoriously hard-to-treat basal-like breast cancers. Read: https://lnkd.in/e6T4F9YQ #sciencesdelavie #biotechnology #biotechnology #innovation #innovations #research #sciences #medicaments #research #drugresearch #laboratories #labs #chemistry #chemistry #biology #biologie #biopharma #rna #rnatherapeutics #arn #wewillwin

* A Safer, Stable Alternative to Universal CAR T Cells * To address limitations in autologous CAR T cell therapy, Spanish researchers have developed a strategy using CRISPR-Cas9 to create universal anti-CD19 CAR T cells with a defined memory phenotype. This approach reduces graft-versus-host and host-versus-graft responses by targeting B2M and TRAC genes and utilises less differentiated T cells for improved stability and persistence. In the study, CRISPR-Cas9 technology was employed to generate CAR T cells, which were then subjected to CRISPRroots transcriptome analysis to confirm effective gene knockout and ensure no unintended off-target effects. To learn how the generated universal CAR T cells performed, read on at CRISPR Medicine News on https://lnkd.in/er8uNzSv #crispr #geneediting #genomeediting #crisprmedicine Karim Benabdellah GENYO. Pfizer-University of Granada-Junta de Andalucia Center for Genomics and Oncological Research

A recent study, led by researchers Graziano Martello from the Università degli Studi di Padova, Davide Cacchiarelli from Tigem, and James Hackett from EMBL, uncovers the pivotal role of the Esrrb gene in stem cell differentiation. This study unveils how Esrrb orchestrates transformative changes in cellular metabolism and DNA organization during the formative phase of differentiation. These findings not only advance our understanding of cellular development but also hold promising implications for regenerative medicine and clinical research. Their methodology features the recombinant FGF-2, Activin A, and LIF from Qkine for the culture of embryonic stem cells and the differentiation to epiblasts stem cells. Read the full paper here - https://zurl.co/83ZN #StemCells #GrowthFactors #Research

I am attending German Stem Cell Network (GSCN) Conference 2024 in Jena! Come and visit the Scale Biosciences booth to learn how we can support your #singlecell research using an instrument-free approach while enhancing data quality and cost-efficiency. And I have coffee there!   ·      Single Cell RNA Sequencing Kit – Profile up to 500,000 cells with high multiplexing capabilities, handling hundreds of samples in a single run. ·      CRISPR Guide Enrichment Kit – Maximise guide detection and analyze associated mRNA in the same cell for precise, high-resolution insights. ·      Single Cell Methylation Kit – The first commercial solution offering single-cell resolution into methylation states across tens of thousands of cells. ·      Single Cell ATAC Pre-Indexing Kit – Process up to 300,000 nuclei per run at a fraction of the cost while maintaining high data quality.   #GermanStemCellNetwork(GSCN) #SingleCell #Genomics #ScaleBio #100MCellChallenge

Coming up on August 29th at 01:00 UTC - free webinar on A Deep Dive into Optimizing Results from Saliva-Derived DNA. Register now to view it live, ask questions, or access at your convenience. If you have an interest in Genetics research, you will find practical insights from experts with real world applications. Topics include: -Optimizing pre-analytical processing for reliable saliva samples -Assessing quality control measures, including DNA yield, integrity, and quality -Common challenges and solutions for working with oral samples, including comparing collection methods, DNA extraction best practices, compatibility with common extraction methods, preparing extracted DNA for downstream applications, comparability to blood samples, and manual and automated extraction workflows and efficiencies -Stem Cell Transplantation: Maximizing HLA-Match Accuracy Using Saliva-Derived DNA, including goals of the Malaysian Stem Cell Registry, populations, protocols, data collection and analysis, sample type rationale, and how sample collection methods affect Registry outcomes. https://lnkd.in/ezv-NJ9x

New “GPS nanoparticle” delivers a genetic punch to the protein implicated in tumor spread. A newly developed "GPS nanoparticle" injected intravenously can home in on cancer cells to deliver a genetic punch to the protein implicated in tumor growth and spread, according to researchers from Penn State. They tested their approach in human cell lines and in mice to effectively knock down a cancer-causing gene, reporting that the technique may potentially offer a more precise and effective treatment for notoriously hard-to-treat basal-like breast cancers. Read: https://lnkd.in/e2U6sXap #sciencesdelavie #biotechnology #biotechnology #innovation #innovations #research #sciences #medicaments #research #drugresearch #laboratories #labs #chemistry #chemistry #biology #biologie #biopharma #rna #rnatherapeutics #arn #wewillwin

𝐅𝐨𝐬𝐭𝐞𝐫 𝐈𝐦𝐩𝐚𝐜𝐭𝐟𝐮𝐥 𝐃𝐢𝐬𝐜𝐮𝐬𝐬𝐢𝐨𝐧𝐬 𝐚𝐭 𝐈𝐦𝐦𝐮𝐧𝐨 𝟐𝟎𝟐𝟒! 🤝 Day One Track 4 is dedicated to the 'Discovery of Novel Targets in Immuno-Oncology: Identification, Validation & Exploration,' featuring insights from Mani Mudaliar, Massimiliano Mellone, Sophia N Karagiannis, Mark Cragg, Rick Kamps, and Amit Grover! 📚 This track is divided into two parts: 𝐏𝐚𝐫𝐭 𝟏 ✔️ Checkpoint inhibitors ✔️ Novel identification strategies ✔️ Emerging target identification and validation strategies, methods ✔️ Technological approaches: High-throughput screening, computational biology, genomic sequencing, CRISPR 𝐏𝐚𝐫𝐭 𝟐 ✔️ Solid tumours/tumour microenvironment ✔️ Case studies & latest developments in cellular therapies: NK Cells, Myeloid Cell, Stem Cells (MSCs, HSCs, PSCs/iPSCs ➡️📖 Explore the exciting agenda: https://hubs.la/Q02jQ1j-0 #OGImmuno #Immuno24 #NovelTargets #TumourMicroenvironment