BioLamina’s Post

New Clinical Trial Take a look at this new medicine, derived from umbilical cord and pericardium stem cells from tissue donors, is a world-first tissue engineering product (a type of advanced therapy combining cells and tissues optimized in the laboratory). Click below to find out more from medicalxpress.com

Our latest Cool Tools looks at hydrogels and their ability to encapsulate cells and support their growth within a 3D gel matrix. Specifically, new ECM hydrogel products that are optimized to support a wide variety of 3D cell culture techniques, including Patient-Derived Xenograft (PDX), organoids, spheroids and induced pluripotent stem cell (iPSC) culture. https://lnkd.in/eK7DYxGP #3dcellculture

【Cited FineTest ELISA Kit】GAGs ELISA Kit | ACS Nano | IF: 17.1 Abstract: FineTest GAGs ELISA Kit is cited by an article entitled "Sophisticated Magneto-Mechanical Actuation Promotes In Situ Stem Cell Assembly and Chondrogenesis for Treating Osteoarthritis" Published in ACS Nano. (Read Full Text: https://bit.ly/3MgZhIC) Keywords: #StemCellTherapy, #StemCellResearch, #Biomaterials, #Nanoparticles, #Arthritis, #Osteoarthritis, #OsteoarthritisTreatment, #MusculoskeletalHealth, #Inflammation, #MagneticField

Our latest Cool Tools looks at hydrogels and their ability to encapsulate cells and support their growth within a 3D gel matrix. Specifically, new ECM hydrogel products that are optimized to support a wide variety of 3D cell culture techniques, including Patient-Derived Xenograft (PDX), organoids, spheroids and induced pluripotent stem cell (iPSC) culture. https://lnkd.in/ebftxdE8 #3dcellculture

Unveiling the Future: Stimulus-Responsive Biomaterials! Discover the transformative power of smart biomaterials in our latest blog post. These innovations are redefining medical treatments and technology, from targeted cancer therapy to advanced wound healing. From temperature-sensitive gels to light-responsive materials, discover how these intelligent biomaterials respond to environmental stimuli, offering precision and versatility in applications ranging from drug delivery systems to regenerative medicine. Learn about: Temperature-Sensitive Innovations for Cancer Therapy pH-Responsive Materials for Wound Management Light-Responsive Nanoparticles for Non-Invasive Skin Cancer Treatment And much more! Join us at Revive, where we navigate the future of biomaterials science, harnessing the power of these materials to solve some of the world's most complex medical challenges. Read the full article here: https://lnkd.in/dw6D7w8a Don't forget to share your views in the comments #StimulusResponsiveBiomaterials #BiomedicalEngineering #InnovationInMedicine #SmartMaterials #ReviveTheFuture #InnovationInHealthcare #ReviveMedicalTechnologies #RMT #biomaterials #drugdelivery

Transcriptomic Profiling of Human Mesenchymal Stem Cells Using a Pulsed Electromagnetic-Wave Motion Bioreactor System for Enhanced Osteogenic Commitment and Therapeutic Potentials Herein, we present the use a pulse electromagnetic fields (pEMFs)-assisted wave-motion bioreactor system for the dynamic and scalable culture of human bone marrow-derived mesenchymal stem cells (hBMSCs) with enhanced the secretion of various soluble factors with massive therapeutic potential. The present study investigated the influence of dynamic pEMF (D-pEMF) on the kinetic of hBMSCs. A 30-minute exposure of pEMF (10V-1Hz, 5.82 G) with 35 oscillations per minute (OPM) rocking speed can induce the proliferation (1 × 105 → 4.5 × 105) of hBMSCs than static culture. Furthermore, the culture of hBMSCs in osteo-induction media revealed a greater enhancement of osteogenic transcription factors under the D-pEMF condition, suggesting that D-pEMF addition significantly boosted hBMSCs osteogenesis. https://lnkd.in/g7rHMjnN #aspenalert #biotech #bioprocess

VIEW | Fluorescent dyes that emit in the second near-infrared (NIR-II, 1000–3000 nm)region have provided significant advances toward real-time and high-resolutionimaging of vessel and lymphatic system. However, in vivo NIR-II tracking ofthe fate of labeled cells still remains challenging. Here, we develop a shield-ing unit–donor–acceptor–donor–shielding unit (S-D-A-D-S) NIR-II fluorophore(FE-4ZW) with zwitterionic terminal groups for high-efficiency cell labelingwithout using cell-penetrating peptides, which provides for enhanced non-invasive in vivo determination of the location of cell migration. The tetheringterminal sulfoammonium inner salts are featured with its high affinity for cellmembranes, thereby enabling the stable labeling even for fixed cells. The fate oftransplanted stem cell and the tumor cell migration along lymphatic system inbrain or periphery tissues are clearly monitored by the cell-internalized FE-4ZW. We also confirmed that a clinically used surfactant, D-α-tocopheryl polyethyleneglycol-1000 succinate, can reduce the liver and spleen uptake of FE-4ZW. Thefluorophore design strategy and cell-labeling technology reported here open anew realm in the visualization of cell migration and insight into the relocation process, thereby ultimately providing an opportunity to investigate in greaterdetail of the underlying mechanisms of stem cell therapy and tumor metastasis. For the full research, please view: https://lnkd.in/g9yQXWYG #VIEW is a high-quality, interdisciplinary, and rapid-publication open access journal focusing on “biodiagnostics” in the field of biomaterials. From in vitro to in vivo, small to mega, fundamentals to application, with an emphasis on the biomaterials used particularly in biotechnology and medicine.

🔬 Stay Up-to-Date on Biomaterials Research 🔬 Our September issue is available online with 1 review paper on Graphene-based biomaterials for bone tissue engineering and 9 brilliant original articles on biomaterials applications from nanotechnology to soft/hard tissue engineering applications waiting for you to know about. https://lnkd.in/eUeZfUXf 📢 Highlighted Research Paper: 📢 🔍Harnessing the Power of Exosomes: Sweroside Shields Against Sepsis-Induced Myocardial Injury Sepsis is a life-threatening problem marked by organ dysfunction driven by negative inflammatory responses and stimulated oxidative stress, with up to 60% of sepsis patients experiencing myocardial injury. This published research explores the potential of stem cell-derived exosomes (EXO) combined with the natural therapeutic agent called Sweroside (SWO), in mitigating sepsis-related myocardial injury. 🌟 Key Findings 🌟 💡Stem cell-derived exosomes show promise in treating sepsis-induced myocardial injury. 💡Sweroside-functionalized exosomes effectively control inflammatory responses. 💡Sweroside vesicles significantly reduce ROS generation. 💡SWO/EXO formulations lead to a significant reduction in pro-inflammatory cytokines. 💡SWO/EXO emerges as a potent therapeutic candidate for SMI (Sepsis-Induced Myocardial Injury) therapy. The study concludes that the in vivo and in vitro protection against LPS-induced myocardial injury using SWO-loaded EXO vesicles. SWO/EXO mixtures effectively reduce LPS-induced myocardial injury by inhibiting cell apoptosis, oxidative damage, and mitochondrial dysfunction triggered by sepsis. This research lays the foundation for a promising treatment approach to combat sepsis-related myocardiopathy by combining native SWO components with EXO vesicles. Future clinical applications await further research. 🌐👏Join us in exploring the latest advancements in biomaterials research in our September issue. Access the full paper and other exciting articles now! #Biomaterials #SepsisResearch #Innovation #Science #JournalofBiomaterialsApplication #ResearchHighlight #SagePublishing

The results of a pioneering study support the safety of the bioimplants called PeriCord, made from stem cells of the umbilical cord and pericardium from a tissue donor, which aid in the regeneration and revascularization of the affected area.

DON'T BE DUMB, READ THIS 🤓 | Smart-Bombing #Cancer | Online OPEN ACCESS Review 👍 | #Tumors | #Nanotechnology | #PersonalizedMedicine | #ArtificialIntelligence | #Immunotherapy | #DrugDelivery | #Polymers | Smart nanoparticles, which can respond to biological cues or be guided by them, are emerging as a promising drug delivery platform for precise cancer treatment. The field of oncology, nanotechnology, and biomedicine has witnessed rapid progress, leading to innovative developments in smart nanoparticles for safer and more effective cancer therapy. In this review, the authors highlight recent advancements in smart nanoparticles, including polymeric nanoparticles, dendrimers, micelles, liposomes, protein nanoparticles, cell membrane nanoparticles, mesoporous silica nanoparticles, gold nanoparticles, iron oxide nanoparticles, quantum dots, carbon nanotubes, black phosphorus, MOF nanoparticles, and others. They focus on their classification, structures, synthesis, and intelligent features. These smart nanoparticles possess the ability to respond to various external and internal stimuli, such as enzymes, pH, temperature, optics, and magnetism, making them intelligent systems. Additionally, this review explores the latest studies on tumor targeting by functionalizing the surfaces of smart nanoparticles with tumor-specific ligands like antibodies, peptides, transferrin, and folic acid. They also summarize different types of drug delivery options, including small molecules, peptides, proteins, nucleic acids, and even living cells, for their potential use in cancer therapy. While the potential of smart nanoparticles is promising, they also acknowledge the challenges and clinical prospects associated with their use. Finally, they propose a blueprint that involves the use of artificial intelligence-powered nanoparticles in cancer treatment applications. By harnessing the potential of smart nanoparticles, this review aims to usher in a new era of precise and personalized cancer therapy, providing patients with individualized treatment options. Celentyx Ltd Professor Nicholas Barnes PhD, FBPhS Omar Qureshi Catherine Brady SCHEMATIC of smart nanoparticles for cancer treatment