Biopharma PEG Scientific Inc.’s Post

GTxResolve SEC Columns offer high resolution, low adsorption, and robust performance for analyzing lipid nanoparticles (LNPs), nucleic acids, and viral vectors. They enable accelerated aggregate and size variant analysis, reproducible data for platform methods, and cost savings through their long shelf life. Additionally, these columns achieve low secondary interaction and provide low adsorption hardware, enhancing recovery for biologics. https://bit.ly/4ch20w2 #cellandgenetherapy #viralvectors #lipidnanoparticles #aggregateanalysis

Join PDA Southern California Chapter on August 15 for our Visible Particulates Symposium at BioscienceLA Speakers include Austin Caudle, Xueyuan (Shawn) Wang, Robin Manouchehri, Amgen, Robert Meisenhelter III, Sladjan Maksimovic, Colleen O'Brien Sonia Adamidis New added topic: "Contamination controls for the rubber stoppers" ^ Understanding Visible Particles and Patient Safety ^ Particulate challenges in Autologous Cell Therapy ^ Enforcement Actions in relation to Particles ^ A Study in Improving Sustainability, whilst Reducing Manufacturing Costs ^ Annex 1, Compliant Contamination Control Strategies ^ Achieving Particle Reduction via Supplier Annex 1 Strategies and Innovation in RTF Packaging Register Here: https://lnkd.in/gdAcJFZc https://lnkd.in/gJpdGd7h Amgen Kite Pharma Gerresheimer SCHOTT Redica Systems West Pharmaceutical Services

🚀 Exciting Advances in ADC Analysis! 🚀 Check out our recent application note that highlights the powerful capabilities of the ACQUITY™ Premier UPLC™ System and Xevo™ G3 QTof Mass Spectrometer for the analysis of intact lysine-conjugated Antibody-Drug Conjugates (ADCs). This innovative approach leverages high-resolution mass spectrometry to provide detailed insights into the drug-to-antibody ratio (DAR), a critical parameter for the efficacy and safety of ADC therapeutics. The streamlined workflow, powered by the waters_connect™ UNIFI™ App, ensures accurate and automated DAR calculations, minimizing the risk of manual errors. -Enhanced System Uptime: Thanks to the high-performance surfaces (HPS) of the ACQUITY Premier UPLC System. -Sensitive Detection: The Xevo G3 QTof Mass Spectrometer offers robust and accurate detection of biomolecules. -Automated Data Processing: Custom calculations in the UNIFI App streamline the ADC workflow. This advancement is a step forward in the field of biopharmaceutical analysis, promising more reliable and efficient characterization of complex ADCs. 🌟 Check out the full application note for more details: https://lnkd.in/eveC4DTE #Biopharma #MassSpectrometry #ADCs #UPLC #Innovation

Exploring Arbidol's Conformational Behavior in Supercritical Carbon Dioxide: Unveiling 'Opened' and 'Closed' Conformer Groups In a groundbreaking study, researchers Konstantin V. Belov, Alexey A. Dyshin, and Ilya A. Khodov have delved into the conformational intricacies of arbidol, a pharmaceutical compound renowned for its broad applications in antiviral and immunomodulatory therapies. The research, published in the journal Molecular Liquids, focuses on arbidol's behavior in a supercritical carbon dioxide solution, shedding light on the compound's various conformers. https://lnkd.in/dNuwmK43

"Although the iPRECIO pump substantially modified the PK curve for G7883, resulting in sustained delivery and prevention of body weight loss over time, the plasma concentrations remained below the target IC50 (Figure 3 A,B). " "Due to G7883’s poor solubility, the ability to sufficiently solubilize it at a higher concentration while maintaining compatibility with the iPRECIO pump system reached its limits." "In contrast, the iPRECIO pump successfully maintained the target concentration profile for G6893, partially due to the lower IC50 and, accordingly, the lower required systemic concentration to achieve the target coverage over time ( Figure 3 C). Based on the physicochemical properties of the compounds, G6893 proved more amenable for application with the iPRECIO pump system compared with G7883. " Keywords: drug delivery; PO; IV infusion; IP; SC; small molecule; PK profile; exposure Shared excerpts without modification from An, Le, et al. "Early Stage Preclinical Formulation Strategies to Alter the Pharmacokinetic Profile of Two Small Molecule Therapeutics." Pharmaceuticals 17.2 (2024): 179. #drugdiscovery #formulations #PK CC BY 4.0 DEED Attribution 4.0 International

If you work with hepatocytes you know having a proper monolayer is essential. Now you can eliminate that challenge with plates of Opti-HEP seeded at the optimal density

Programmable medicines are an emerging field in medical science that combines principles from #nanotechnology, #biotechnology, and #pharmacology. These innovative therapies are designed to be more targeted, controllable, and customizable than traditional medicines. Here's a brief overview: 1. Key features: - Targeted delivery: Can be directed to specific cells or tissues - Controlled release: Medication release can be timed or triggered - Adjustable dosing: Dose can be modified based on patient response - Multifunctionality: Can perform multiple tasks, like diagnosis and treatment 2. Technologies involved: - Nanoparticles - Smart polymers - DNA/RNA-based systems - Optogenetics - #CRISPR 3. Advantages: - Increased efficacy - Reduced side effects - More precise treatment - Potential for real-time monitoring and adjustment Kudos to Flagship Pioneering to always being in the forefront of science.

If you are attending Festival of Biologics this week in San Diego make sure to stop Scott and Pavan to learn how Almac can assist you with your biologic testing goals! With a deep arsenal of cutting edge analytical techniques and extensive industry experience Almac are more than capable to assist you with any outsourced analytical requirements you may have, irrespective of where you are on your drug development journey. #Biologics #analytical #analyticaltesting #methoddevelopment #methodvalidation #stabilitystudy #almac #festivalofbiologics #sandiego #monoclonalantibody #genetherapy #adc #outsourcing #outsourcedtesting

AI models in biology don't have enough high quality data. — We're changing that. Our newest data generation product for antibody developability produces huge AI-ready datasets by testing thousands of Abs across 8 key developability assays. Use the service to train a new model, validate an existing one, and accelerate your candidate selection. Check out our sample dataset of 20 IgG antibodies to see what's possible. DM me or visit our website to learn more. #biotech #AI #drugdevelopment #antibodies #mAb

Can your CDMO tackle Host Cell Proteins?   One of our clients outsourced their #mAb drug product to a Contract Development and Manufacturing Organization (CDMO).   They depended on the CDMO to ensure the purity and efficacy of their product. However, the drug showed poor stability over time, and the CDMO could not identify the cause.   🎥 Watch this video to learn how we helped our client eliminate several lipases and improve product stability – and how we can collaborate with your CDMO to keep your product timeline on track.