Olufunmilayo (Funmi) Olopade

Strategies to Prevent the emergence and spread of # antimicrobial resistance (AMR)

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Dive into the insightful world of clinical research with Dr. Bushra Khan as she delves into Experimental Study designs and the critical questions they address. Our structured approach ensures easy comprehension, empowering you to stay updated with the latest developments in the field. Don't miss out on this invaluable resource for professional growth! #ClinicalResearch #StudyDesigns #ProfessionalDevelopment 📊🔬

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On The Guardian today..."Giant publishers are bleeding universities dry, with profit margins that rival Google’s" Read the extracts below and full text on the link. This is why Critical Care Science is a FULL OPEN ACCESS (Diamond open-access) Journal with no fees to read or to publish! “To answer this, we have to go back a few decades, when commercial publishers began buying up journals from university presses. Exploiting their monopoly position, they then sharply raised prices. Today, a library subscription to a single journal in the humanities or social sciences typically costs more than £1,000 a year. “ “Even more astonishing is the fact these publishers often charge authors for the privilege of publishing in their journals. In recent years, large publishers have begun offering so-called “open access” articles that are free to read. On the surface, this might sound like a welcome improvement. But for-profit publishers provide open access to readers only by charging authors, often thousands of pounds, to publish their own articles. Who ends up paying these substantial author fees? Once again, universities. “ “This trend is having an insidious impact on knowledge production. Commercial publishers are incentivised to try to publish as many articles and journals as possible, because each additional article brings in more profit. This has led to a proliferation of junk journals that publish fake research, and has increased the pressure on rigorous journals to weaken their quality controls. It’s never been more evident that for-profit publishing simply does not align with the aims of scholarly inquiry.” “There is an obvious alternative: universities, libraries, and academic funding agencies can cut out the intermediary and directly fund journals themselves, at a far lower cost. This would remove commercial pressures from the editorial process, preserve editorial integrity and make research accessible to all. The term for this is “diamond” open access, which means the publishers charge neither authors, editors, nor readers .” https://lnkd.in/eetEn2E8 Associação de Medicina Intensiva Brasileira - AMIB Filipe Amado, MD Vanessa Soares Lanziotti, MD, MSc, PhD

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This paper does analyze a range of factors influencing the decisions to invest in RD research that are recognized by investors. The different types of funders were investigated, in association with the key motivating factors for funding RD research and the stages of research to invest in, as well as the diverse partnerships between different kinds of funders. A new model of funding is needed, technology is far beyond and we need to focus on new visions involving patients’ voice.

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#Openaccess Carlton et al: Frequency & Risk Factors for ⬆️Healthcare Utilization #pedsICU #SurvivingSepsis 🖥️2016–2019 MarketScan Comm & Medicaid Link: https://ow.ly/YILQ50TO3OO Editorial: https://ow.ly/UwG350TO3OQ Society of Critical Care Medicine Fig: Risk factors predicting 3d of healthcare use 90d post-sepsis discharge

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Important study alert!! 40% of cancers are attributable to potentially modifiable risk factors, such as smoking, BMI, alcohol, lack of exercise, infection and diet. We all need to do our part to help out! If we all reduce are risks to create a healthier population, we can reduce cancer burden. And get screened where screening is available. #cancerresearchworks #reduceyourrisk

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Thrilled to share a recent comprehensive narrative review published in AGING MEDICINE (Wiley)! I am very appreciative of Dr. Sana Mohammadi and Prof. Farzad Fatehi for their cooperation and engagement. Highlights: ■ Iron accumulation in the brain, especially in the #precuneus region, is an emerging area of research in Alzheimer's disease (AD). This post will explore how iron overload is linked to AD risk factors. ◇ AD is characterized by amyloid_plaques, neurofibrillary_tangles, and neuronal loss. While aging is the most significant risk factor, metabolic dysfunction and iron dysregulation also contribute to AD development. ◇ Iron plays a vital role in oxygen transport and various protein functions. However, abnormal iron accumulation can have detrimental effects. ◇ The precuneus, a brain region crucial for cognitive functions, is particularly vulnerable to iron accumulation in AD. Research suggests that iron deposition in this area can lead to oxidative stress, neuroinflammation, and accelerated neurodegeneration. ● Several factors (directly or indirectly) can contribute to abnormal iron accumulation in the precuneus: ▪︎ Metabolic disorders, including diabetes, obesity, and non-alcoholic fatty liver disease (NAFLD), are associated with iron accumulation in the brain. ▪︎ Visceral adipose tissue (VAT), the fat stored around the organs, releases adipokines that disrupt brain iron homeostasis and contribute to neuroinflammation. Studies have linked higher VAT in midlife to Alzheimer's development. ▪︎ NAFLD, often linked to obesity, can also disrupt iron levels in the body, leading to a condition known as dysmetabolic iron overload syndrome. ▪︎ Genetic factors, such as those involved in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL), can also influence iron deposition in the brain. □ Tracking with Quantitative Susceptibility Mapping • QSM is a novel post-processing neuroimaging technique that offers insights into tissue magnetic susceptibility levels (which can translate to iron levels) and cerebral oxygen metabolism. • QSM has shown promise in identifying abnormal iron accumulation in the precuneus early in AD. • Researchers believe QSM could be valuable as a non-invasive biomarker for tracking disease progression, complementing other imaging modalities, and aiding in early AD diagnosis and monitoring. Thus, iron accumulation in the precuneus may be a potential key player in AD development and progression. More research is needed to fully understand the relationship between iron overload and the various risk factors associated with AD. Anyway, QSM shows emerging evidence as a tool for early detection and monitoring of iron accumulation! 👉 Read the full article here: Iron accumulation/overload and Alzheimer's disease risk factors in the precuneus region; https://lnkd.in/ddqPu4iz

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RSV VACCINATION (Abrysvo) IN HIGH-RISK ADULTS LIVING IN THE UNITED STATES DEMONSTRATES SIGNIFICANTLY HIGHER REAL-WORLD EFFECTIVENESS COMPARED TO THE DATA PREVIOULSY PUBLISHED IN JAMA: From November 2023-April 2024, adjusted RSV vaccine effectiveness against hospitalizations or ED visits was 90% (95% CI 24-99) among adults ages 60 and older during the first 5 months of vaccine availability, reported Sara Tartof, PhD, MPH, of Kaiser Permanente in Pasadena, California, at the IDWeek anual meeting in Los Angeles. Also, in a secondary analysis, adjusted vaccine effectiveness against RSV-related acute respiratory illness (ARI) ED visits was 93% (95% CI 47-99) and 91% against RSV-related ARI ED visits or hospitalizations (95% CI 61-89). Among test-positive cases, 99.7% were unvaccinated (n=371) and 0.3% (n=1) were vaccinated. Among the test-negative controls, 96.8% (n=480) were unvaccinated and 3.2% (n=16) were vaccinated. #RSV #RSVVACCINATION https://lnkd.in/g3gHBXJ7

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Effects of Restarting Renin-Angiotensin System Inhibitors (RASi) after Discontinuation on Kidney Outcomes and Mortality ca. 2024 #Nephpearls 👉🏼 https://lnkd.in/g4PtZBKq

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A recent Nature Medicine publication led by Nick Marston expands our understanding of the cardiovascular risk imparted by clonal hematopoiesis of indeterminate potential (CHIP), a newly recognized an common cardiovascular risk factor that links heart diseases, cancer, and aging, and opening up new vistas of understanding these global scourges. #heartattack #myocardialinfarction #cardiovasculardisease #clonalhematopoiesis #CHIP #hematology #oncology #cardiology #ageing #gerontology #cancer

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From American College of Physicians's Annals of Internal Medicine: A retrospective observational study on a 20% random sample of Medicare fee-for-service beneficiaries hospitalized, 2016-19, and treated by hospitalists suggests that "patients have lower mortality and readmission rates when treated by female physicians, and the benefit of receiving treatments from female physicians is larger for female patients than for male patients." Despite the limitations of the study, I am not surprised by the findings. https://lnkd.in/er6umnnT #womenphysicians #femalephysicians

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For healthspan and lifespan, ERK, AMPK and mTORC1 represent critical pathways and #inflammation is a centrally important hallmark1,2,3,4,5,6,7. Here we examined whether IL-11, a pro- #inflammatory #cytokine of the IL-6 family, has a negative effect on age-associated #disease and #lifespan. As mice age, IL-11 is upregulated across cell types and tissues to regulate an ERK–AMPK–mTORC1 axis to modulate cellular, tissue- and organismal-level ageing pathologies. Deletion of Il11 or Il11ra1 protects against #metabolic decline, multi-morbidity and #frailty in #oldage. Administration of anti-IL-11 to 75-week-old mice for 25 weeks improves #metabolism and muscle function, and reduces ageing #biomarkers and frailty across sexes. In lifespan studies, #genetic deletion of Il11 extended the lives of mice of both sexes, by 24.9% on average. Treatment with anti-IL-11 from 75 weeks of age until death extends the median lifespan of male mice by 22.5% and of female mice by 25%. Together, these results demonstrate a role for the pro-inflammatory factor IL-11 in mammalian healthspan and lifespan. We suggest that anti-IL-11 therapy, which is currently in early-stage clinical trials for fibrotic #lungdisease, may provide a translational opportunity to determine the effects of IL-11 inhibition on ageing pathologies in older people. https://lnkd.in/eSwCGYgG #cytokines #immunology #autoimmunedisease #inflammation National Institute on Aging (NIA) #elderly #regenerativemedicine #stemcells #nih #biopharma #genomics #publichealth

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A new study in #Med examined the relationship between #UniversalHealthCoverage (UHC) and cancer mortality rates. The findings suggest that higher levels of UHC are associated with decreased mortality rates for various cancers, highlighting the importance of improving access to targeted and effective cancer care in achieving UHC and reducing cancer-related deaths. https://lnkd.in/ejqXTsFS #HealthEquity #GlobalHealth #PublicHealth

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In the second of a series of articles advocating that #LessIsMore, I discuss the development and use of biomarkers in clinical practice. This roadmap explores critical decision-making points and attempts to strike a balance between the usefulness of biomarkers and the potential drawbacks of excessive testing - including the cascade of follow-up tests and interventions that often fail to translate into meaningful and measurable improvements in health and well-being.

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Take-home messages of Industry Payments to Cardiology Fellows and Early-Career Cardiologists, just published in JAMA Internal Medicine: -> Most US cardiology fellows received general payments from pharmaceutical and medical device manufacturers during their final year of training, with higher rates among those in procedural intensive subspecialties. -> There are consequences for patients because industry payments to physicians are associated with less evidence-based practice https://lnkd.in/dnsEVW42

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***Publication alert*** Mols, F., Schoormans, D., Oerlemans, S. et al. Patient-reported outcomes in cancer survivorship: insights from two decades of population-based PROFILES registry research. J Cancer Surviv (2024). https://lnkd.in/egj2FVf2 New Review of the PROFILES Registry Highlights Key Advances in Cancer Survivorship Research A comprehensive review of the Patient-Reported Outcomes Following Initial treatment and Long-term Evaluation of Survivorship (PROFILES) registry reveals critical insights from nearly 20 years of cancer survivorship research. Established in 2004, the PROFILES registry was developed to track patient-reported outcomes (PROs) in cancer survivors and a normative population. This review outlines key advances in study methodologies, data collection practices, interdisciplinary collaboration, societal impact, and data sharing strategies. Purpose and Methodology This scoping review includes findings from 249 published papers covering 35 studies conducted from 2004 to 2023. Data from the PROFILES registry, one of the leading resources for understanding cancer survivorship, formed the basis of the analysis, with a systematic literature search through PubMed collecting relevant studies. Key Findings The review emphasizes the importance of multi-hospital collaboration, which has increased participant inclusion and ensured that research findings are generalizable. Optimizing response rates and patient inclusion were achieved by integrating healthcare professionals in data collection and utilizing both web-based and paper questionnaires. Longitudinal studies from the PROFILES registry offer invaluable insights into the long-term effects of cancer and its treatments on survivors, spanning from diagnosis through survivorship. Combining PRO data with clinical information from registries has been essential in ensuring data reliability and robust conclusions. A shift towards open-access publishing, data sharing, and interdisciplinary collaboration has expanded the impact of PROFILES research, making findings accessible to a broader audience, including healthcare providers and policymakers. Conclusions This review demonstrates the value of collaboration, adaptive data collection methods, and the integration of PROs with clinical data in advancing cancer survivorship research. Implications for Cancer Survivors The insights from the PROFILES registry are expected to guide future research, aiming to improve survivorship care and quality of life for cancer survivors through interdisciplinary collaboration and continued data sharing. About PROFILES Established in 2004, the PROFILES registry tracks the long-term effects of cancer and its treatments through patient-reported outcomes. This registry provides vital data to improve the quality of life for cancer survivors by shaping research and care strategies. Dounya Schoormans, Nicole Ezendam, Nicole Horevoorts, Simone Oerlemans, Natasja Raijmakers, Lonneke van de Poll-Franse

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Attention all Global Family Medicine educators, champions, friends and advocates! Call For Papers— Global Family Medicine Education Theme Issue Call for Papers Submission deadline: November 15 Family Medicine seeks submissions for its upcoming theme issue on models of family medicine education around the world. Regardless of location, global family medicine educational programs face many similar challenges. Whether based in settings where family medicine is a novel specialty, or in areas where family medicine is long-established, faculty and academic units often struggle to advocate for appropriate resources and political support to remain viable and community responsive. Additionally, there are many challenges (ex: climate change and planetary health, burnout, and retention) for which we face a common need to innovate in order to ensure adequate family medicine education regardless of our country or region. For this theme issue, Family Medicine welcomes submissions that focus on successful efforts to advocate for family medicine education and training within local and global health systems; impact assessment of family medicine on populations served; barriers to family medicine training and evidence-based solutions to navigating those barriers; and creative partnership approaches to strengthen training between education programs located across international borders. Original research and brief reports are welcome. Narrative essay submissions should share original stories from the perspective of students, residents, faculty members, or practicing physicians. FM Focus submissions must have high yield, concise information that will be published as an infographic. Word limits and structure for the above manuscripts should follow those detailed in our author instructions. We specifically encourage submission by family medicine educators based outside of the United States. #FamilyMedicine #FamilyPractice

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