Melissa Olivadoti, PhD, CMPP

Melissa Olivadoti, PhD, CMPP

Las Vegas Metropolitan Area
868 followers 500+ connections

About

Medical Affairs Consultant, strategic thinker, lifelong learner, enthusiastic team…

Services

Contributions

Activity

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Experience

  • Assisi Medical Affairs Consulting Graphic

    Assisi Medical Affairs Consulting

    Las Vegas Metropolitan Area

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    Las Vegas, Nevada, United States

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    Las Vegas, Nevada, United States

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    Las Vegas Metropolitan Area

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    Alamogordo, NM

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    Dayton, Ohio Area

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    Las Vegas, Nevada Area

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    Las Vegas, Nevada

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    Las Vegas, NV

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    las vegas, nv

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    Las Vegas, Nevada Area

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    West and Southwest regions

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Education

  • University of Michigan Graphic

    University of Michigan

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    Activities and Societies: Biomedical Graduate Student Council, Neuroscience Graduate Student Organization

    Thesis research on post-viral fatigue and sleep in a mouse model of mononucleosis.

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    Activities and Societies: Penn State Swing Dancing Club (Founder and past President), La Vie PSU yearbook photography/literary committee, Distinguished Speaker Series Student Committee

Licenses & Certifications

Volunteer Experience

  • The Animal Foundation Graphic

    Feline Foster Parent

    The Animal Foundation

    - Present 11 years 5 months

    Animal Welfare

    Foster cats and kittens of all stages, specializing in special medical needs and feral/abuse rehabilitation.

  • Nevada SPCA Graphic

    Feline Foster Parent

    Nevada SPCA

    - Present 4 years 2 months

    Animal Welfare

    Fostering cats and kittens of all stages. Specializing in feral and abuse rehabilitation.

  • Global Lyme Alliance Graphic

    Lyme Ambassador

    Global Lyme Alliance

    - Present 1 year 7 months

    Health

    Educational and awareness ambassador for Lyme and tick borne diseases.

  • Animal care volunteer, Instagram and Blog Manager

    Kitty City NM

    - 2 years 2 months

    Animal Welfare

    Basic cat care for shelter animals (feeding, cleaning, medication, socialization), managing daily posts of available animals on the shelter instagram, and writing articles for the Kitty City blog on topics related to animal care and adoption.
    https://www.instagram.com/kittycitynm/

  • SICSA Pet Adoption Center Graphic

    Cat foster, cat volunteer, special events volunteer

    SICSA Pet Adoption Center

    - 1 year 9 months

    Animal Welfare

  • Best Friends Animal Society Graphic

    Volunteer

    Best Friends Animal Society

    - Present 9 years 11 months

    Animal Welfare

    I take periodic trips to volunteer in Cat World for the Best Friends Animal Society. Volunteer activities include socialization and basic animal care.

  • Animal Care Volunteer

    The Sloth Sanctuary of Costa Rica

    - 2 months

    Animal Welfare

    I have worked at the Sloth Sanctuary on two separate trips to Cost Rica. Volunteer activities included general sloth husbandry, baby sloth care, and rehabilitation.

  • Animal Care Volunteer

    BatReach, Cairns, Australia

    - 2 months

    Animal Welfare

    I have taken three trips to BatReach to volunteer with fruit bats and small marsupials. Volunteer activities included basic animal husbandry and care for special needs animals, as well as reintroduction to the wild.

  • Alumni Mentor

    Schreyer Honors College, Penn State University

    - Present 7 years 11 months

    Education

    Mentoring current students in the Schreyer honors program at Penn State University in academics and on their employment trajectory.

  • Irvine Animal Care Center Graphic

    Foster, Volunteer

    Irvine Animal Care Center

    - 8 years

    Animal Welfare

  • PURRS ABOUND SIAMESE RESCUE OF MICHIGAN INC Graphic

    Foster Parent

    PURRS ABOUND SIAMESE RESCUE OF MICHIGAN INC

    - 4 years 8 months

Publications

  • Safety and Efficacy of VP-102 (0.7% w/v cantharidin) in Molluscum Contagiosum (MC) by Lesion Location: Pooled Results of Two Phase 3 Multicenter, Randomized, Vehicle-Controlled Trials

    Winter Clinical Dermatology Congress (Poster)

  • ≥75% and ≥90% clearance rates for treated lesions in CAMP-1 and CAMP-2: Pooled results of two identical, Phase III randomized, vehicle- controlled studies with a novel drug-delivery combination formulation of 0.7% cantharidin (w/v; VP-102) for the topical

    Fall Clinical Dermatology Congress (Poster)

  • Tolerability of Topical Treatments for Atopic Dermatitis

    Dermatol Therapy

    Atopic dermatitis (AD) is a common inflammatory skin disease that is accompanied by increased sensitivity to itch-provoking and pain-provoking stimuli. Patients with AD experience skin pain before initiation of therapy and have also reported painful application site reactions in clinical trials of emollients and prescription topical therapies, including topical corticosteroids (TCSs), topical calcineurin inhibitors (TCIs), and a topical phosphodiesterase 4 (PDE4) inhibitor. To compare the…

    Atopic dermatitis (AD) is a common inflammatory skin disease that is accompanied by increased sensitivity to itch-provoking and pain-provoking stimuli. Patients with AD experience skin pain before initiation of therapy and have also reported painful application site reactions in clinical trials of emollients and prescription topical therapies, including topical corticosteroids (TCSs), topical calcineurin inhibitors (TCIs), and a topical phosphodiesterase 4 (PDE4) inhibitor. To compare the sensory tolerability of prescription topical therapies for AD, a comprehensive literature search and analysis of published clinical trials was conducted. Sensory tolerability issues such as application site pain, burning, stinging, and pruritus were often among the most common adverse events or treatment-related adverse events in clinical trials for prescription topical therapies. Tolerability issues occurred at highest rates in trials of TCIs, followed by trials of the PDE4 inhibitor crisaborole and TCSs, although direct comparisons are not possible because of differences in study design. Tolerability issues in these clinical trials were generally mild to moderate and transient. This article also reviews published strategies for managing sensory tolerability issues in AD patients during treatment with topical therapies

    See publication
  • Sleep and fatigue in mice infected with murine gammaherpesvirus 68.

    Brain Behavior and Immunity

    Murine gammaherpesvirus 68 (γHV68) is a mouse pathogen that shares many similarities with human γHVs, including EBV. In this study, we use γHV68-infected C57BL/6J mice as a model system for studying the impact of chronic viral infection on sleep-wake behavior, activity patterns, and body temperature profiles. Our data show that γHV68 alters sleep, activity, and temperature in a manner suggestive of fatigue. In mice infected with the highest dose used in this study, food intake, body weight…

    Murine gammaherpesvirus 68 (γHV68) is a mouse pathogen that shares many similarities with human γHVs, including EBV. In this study, we use γHV68-infected C57BL/6J mice as a model system for studying the impact of chronic viral infection on sleep-wake behavior, activity patterns, and body temperature profiles. Our data show that γHV68 alters sleep, activity, and temperature in a manner suggestive of fatigue. In mice infected with the highest dose used in this study, food intake, body weight, wheel running, body temperature, and sleep were normal until approximately 7days after infection. These parameters were significantly altered during days 7 through 11, returned to baseline levels at day 12 after infection, and remained within the normal range for the remainder of the 30-day period after inoculation. At that time, both infected and uninfected mice were injected with lipopolysaccharide (LPS), and their responses monitored. Uninfected mice given LPS developed a modest and transient febrile response during the initial light phase (hours 12 through 24) after injection. In contrast, infected mice developed changes in core body temperatures that persisted for at least 5days. Infected mice showed an initial hypothermia that lasted for approximately 12h, followed by a modest fever that persisted for several hours. For the remainder of the 5-day recording period, they showed mild hypothermia during the dark phase. Running wheel activity of infected mice was reduced for at least 5days after injection of LPS, but for only 12h in uninfected mice. These findings indicate that laboratory mice with γHV68 infections may provide a useful model for the study of fatigue and other physiologic and behavioral perturbations that may occur during acute and chronic infection with gammaherpesviruses.

    Other authors
    • Mark Opp; Linda Toth
    • Jason Weinberg
    See publication
  • Effects of i.c.v. administration of interleukin-1 on sleep and body temperature of interleukin-6-deficient mice.

    Neuroscience

    Cytokines in brain contribute to the regulation of physiological processes and complex behavior, including sleep. Administration of these cytokines into laboratory animals, or in some cases into healthy human volunteers, increases the amount of time spent in non-rapid eye movement (NREM) sleep. Although antagonizing the IL-1 or TNF systems reduces the amount of time laboratory animals spend in NREM sleep, interactions among these three cytokine systems as they pertain to the regulation of…

    Cytokines in brain contribute to the regulation of physiological processes and complex behavior, including sleep. Administration of these cytokines into laboratory animals, or in some cases into healthy human volunteers, increases the amount of time spent in non-rapid eye movement (NREM) sleep. Although antagonizing the IL-1 or TNF systems reduces the amount of time laboratory animals spend in NREM sleep, interactions among these three cytokine systems as they pertain to the regulation of physiological NREM sleep are not well understood. To further elucidate mechanisms in brain by which IL-1beta, TNFalpha, and/or IL-6 contribute to NREM sleep regulation, we injected recombinant murine interleukin-1beta (muIL-1beta) into C57BL/6J mice and into IL-6-deficient mice (IL-6 knockout, KO). IL-6 KO (B6.129S6-Il6(tm1Kopf); n=13) and C57BL/6J mice (n=14) were implanted with telemeters to record the electroencephalogram (EEG) and core body temperature, as well as with indwelling guide cannulae targeted to one of the lateral ventricles. After recovery and habituation, mice were injected intracerebroventricularly just prior to dark onset on different days with either 0.5 microl vehicle (pyrogen-free saline; PFS) or with 0.5 microl PFS containing one of four doses of muIL-1beta (2.5 ng, 5 ng, 10 ng, 50 ng). No mouse received more than two doses of muIL-1beta, and administration of muIL-1beta doses was counter-balanced to eliminate potential order effects. Sleep-wake behavior was determined for 24 h after injections. i.c.v. administration of muIL-1beta increased in NREM sleep of both mouse strains in a dose-related fashion, but the maximal increase was of greater magnitude in C57Bl/6J mice. muIL-1beta induced fever in C57Bl/6J mice but not in IL-6 KO mice. Collectively, these data demonstrate IL-6 is necessary for IL-1 to induce fever, but IL-6 is not necessary for IL-1 to alter NREM sleep.

    See publication
  • Murine gammaherpesvirus 68: a model for the study of Epstein-Barr virus infections and related diseases.

    Comp Med

    Epstein-Barr virus (EBV) is a ubiquitous human gammaherpesvirus (GHV) that causes acute infection and establishes life-long latency. EBV is associated with the development of B-cell lymphoproliferative disorders, several malignant cancers, the syndrome of infectious mononucleosis, and chronic interstitial lung disease. Although the molecular biology of EBV has been characterized extensively, the associated disease conditions and their pathogenesis are difficult to study in human populations…

    Epstein-Barr virus (EBV) is a ubiquitous human gammaherpesvirus (GHV) that causes acute infection and establishes life-long latency. EBV is associated with the development of B-cell lymphoproliferative disorders, several malignant cancers, the syndrome of infectious mononucleosis, and chronic interstitial lung disease. Although the molecular biology of EBV has been characterized extensively, the associated disease conditions and their pathogenesis are difficult to study in human populations because of variation in human environments and genetics, the well-documented effect of stressors on pathogenesis, and the chronic and latent properties of the virus. GHV are highly species-specific, and suitable animal models for EBV are not available. However, in 1980, a murine gammaherpesvirus (MuGHV, also known as MHV68 and gammaHV68) was identified as a natural pathogen of bank voles and wood mice. Experimental MuGHV infections in laboratory mice share many features of EBV infections in humans, including facets of the clinical human syndrome known as infectious mononucleosis. These features make MuGHV a valuable experimental model for studying the pathophysiology of a GHV in a natural host.

    See publication

Patents

  • Garment with gastric tube acces

    Issued US

    Other inventors
    • Shelly Santoro

Courses

  • DIA Drug Safety Regulatory Requirements

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  • DIA Postmarketing Safety Reporting

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Honors & Awards

  • The CM Group Award

    The CM Group

    Given to the person who, in magical ways, personifies all of the company's core values as well as aspects of being an unsung hero and a master collaborator. This person fully defines what it means to be a CMG team member.

  • Employee of the Month

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  • Holloman AFB 49th Wing Command Blue Ribbon Volunteer Award

    United States Air Force

    Recognition of volunteerism in the local community (200+ hours) for 2019.

  • Pfizer Upjohn Award

    Aimee Ramcharran

    In recognition of creation and execution of an in-person Field Medical Training week on short notice.

  • Pfizer Upjohn Award

    Joe Konen

    Award recognizing efforts for coordination of 30+ colleagues for scientific coverage, KOL meetings, booth activities and posters, and competitive intelligence sessions for American Academy of Dermatology.

  • Pfizer Upjohn Award

    Andrew Koenig

    For excellence in ownership, planning, and execution of an internal training meeting.

  • Pfizer Upjohn Award

    Eric Guan

    Upjohn Award received for going above and beyond expected performance, demonstrating Pfizer values and the OWNIT! cultural traits by learning the skills to help the team effectively manage a large therapeutic area project budget and manage execution of deliverables.

  • Own It! Business Award

    Pfizer

    Own It! Award is awarded by colleagues within Pfizer to those who have demonstrated "owning the business", taking thoughtful risks, seizing opportunities to think differently, and delivering on projects regardless of experience.

  • NRSA Graduate Student Research Award

    NIH

    NRSA awarded for research thesis in murine gamma herpes virus as a model for post-viral chronic fatigue.

Languages

  • Spanish

    Elementary proficiency

Organizations

  • Bella Amore Ceremonies

    President, Officiant

    - Present

    Officiant for weddings and funerals.

  • Sleep Research Society

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    - Present

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