“Devon was a student in a lab that I taught. He had quite a high-level understanding of each experiment he was working on. His diligence and hard work made him a stellar student in my class.”
Devon Cayer
San Diego County, California, United States
4K followers
500+ connections
About
My entrepreneurial philosophies --
1. Always push the boundaries of what is…
Contributions
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How can you optimize nanomaterial surface area for catalytic applications?
Another method would be thinking of the chemistry of the reaction, and how reactants are reacting with the catalytic components at low concentration if the materials are precious. Borrowing insights from biology, it is possible to enhance avidity with polymeric materials to help transport and funnel reactants towards catalytic regions. This will aid to drive materials out of solution and back into the bulk environment after catalysis. Careful design of polymeric properties and screening of materials will allow for the materials to be developed. First begin with a control reaction in idealized conditions, then slowly make the environment or conditions more strict as optimization of the material improves.
Activity
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In the fourth and final part of our series on Octant’s multiplexing capabilities, we cover the power of Deep Mutational Scans (DMS) to map function…
In the fourth and final part of our series on Octant’s multiplexing capabilities, we cover the power of Deep Mutational Scans (DMS) to map function…
Liked by Devon Cayer
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We have a bio stats/mol biology role opening on my team. Details below:
We have a bio stats/mol biology role opening on my team. Details below:
Liked by Devon Cayer
Experience
Education
Publications
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An enzyme-free, kinetically controlled, isothermal method for the “digital” detection of single nucleotide mismatches
Bioorganic & Medicinal Chemistry Letters
We describe an isothermal, enzyme-free method to detect single nucleotide differences between oligonucleotides of close homology. The approach exploits kinetic differences in toe-hold-mediated, nucleic acid strand-displacement reactions to detect single nucleotide polymorphisms (SNPs) with essentially “digital” precision. The theoretical underpinning, experimental analyses, predictability, and accuracy of this new method are reported. We demonstrate detection of biologically relevant SNPs and…
We describe an isothermal, enzyme-free method to detect single nucleotide differences between oligonucleotides of close homology. The approach exploits kinetic differences in toe-hold-mediated, nucleic acid strand-displacement reactions to detect single nucleotide polymorphisms (SNPs) with essentially “digital” precision. The theoretical underpinning, experimental analyses, predictability, and accuracy of this new method are reported. We demonstrate detection of biologically relevant SNPs and single nucleotide differences in the let-7 family of microRNAs. The method is adaptable to microarray formats, as demonstrated with on-chip detection of SNP variants involved in susceptibility to the therapeutic agents abacavir, Herceptin, and simvastatin.
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Mission critical: the need for proteomics in the era of next-generation sequencing and precision medicine
Human Molecular Genetics
Review covering the current state of multiplex proteomics.
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A modular and general Inhibitor-DNA-Enzyme (IDE) architecture for the isothermal, sequence-specific detection of oligonucleotides
UMI
Thesis Work: "Programmable biomolecules and their applications in diagnostics and therapeutics"
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Prediction of microRNA targets by evoking the endogenous microRNA target-site protection paradigm
UMI
Thesis Work: "Programmable biomolecules and their applications in diagnostics and therapeutics"
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Small molecule-DNA and antibody-DNA directed recruitment of an oligonucleotide regulated enzyme for selective cytotoxicity against tumor cell lines
UMI
Thesis Work: "Programmable biomolecules and their applications in diagnostics and therapeutics"
Patents
Honors & Awards
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Indiebio Accelerator Batch 2
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One of 14 biotech start-up companies selected to build a company in San Francisco for 4 months. Company, MYi Diagnostics and Discovery, received a 250K award for the program.
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Illumina Sequencing Grant
Illumina Accelerator
Upon being a finalist in the Illumina Accelerator Spring 2015 competition, was awarded an Illumina Sequencing Grant to aid in the development of MYi technology.
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Accepted in Y-Combinator S19 Batch
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Did not accept offer due to in-progress fundraise
Languages
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French
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Spanish
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Recommendations received
2 people have recommended Devon
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I’ve continued to struggle to get all my thoughts together about Brant’s passing. What’s helped best is being with others and sharing our stories…
I’ve continued to struggle to get all my thoughts together about Brant’s passing. What’s helped best is being with others and sharing our stories…
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Hi everyone! I'm excited to announce the launch of my new blog, Helix Hub, which aims to introduce biotech to high school and college students as…
Hi everyone! I'm excited to announce the launch of my new blog, Helix Hub, which aims to introduce biotech to high school and college students as…
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Our latest blog post highlighting a result from our recent publication with Nested Therapeutics showing that ADME models trained on a combination of…
Our latest blog post highlighting a result from our recent publication with Nested Therapeutics showing that ADME models trained on a combination of…
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What makes 2nd time founders so good... Attracted to better problems Ruthlessly focus on what matters Have the right network and know how to grow it…
What makes 2nd time founders so good... Attracted to better problems Ruthlessly focus on what matters Have the right network and know how to grow it…
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Why should we care about targeting RNA with small molecules? The transcriptome represents the next frontier in drug discovery. Small molecules are a…
Why should we care about targeting RNA with small molecules? The transcriptome represents the next frontier in drug discovery. Small molecules are a…
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BREAKING NEWS for communities... The WhatsApp integration just DROPPED ✅ A fully monetized WhatsApp group in just 3 minutes. But how? Well, my…
BREAKING NEWS for communities... The WhatsApp integration just DROPPED ✅ A fully monetized WhatsApp group in just 3 minutes. But how? Well, my…
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For the founder/VC/board relationship to work like it is supposed to, founders have to set the goals themselves and the investors/board have to be…
For the founder/VC/board relationship to work like it is supposed to, founders have to set the goals themselves and the investors/board have to be…
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📣 Meet Cash - an Expert Advisor and Early Access Investor in the Sandbox Stack. Cash is a principal on the investment team at Antler, a global…
📣 Meet Cash - an Expert Advisor and Early Access Investor in the Sandbox Stack. Cash is a principal on the investment team at Antler, a global…
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Authenticity can be a king/queenmaker in social, but my LinkedIn persona is different than my IRL persona. Here are some differences, at least for…
Authenticity can be a king/queenmaker in social, but my LinkedIn persona is different than my IRL persona. Here are some differences, at least for…
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Simply "mutating" (digitally varying the bases) of inputs into DNA language models drops out an enormous number of functional genomic…
Simply "mutating" (digitally varying the bases) of inputs into DNA language models drops out an enormous number of functional genomic…
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THIS HIT HOME TODAY...... “Pursue something so important that even if you fail, the world is better off with you having tried.” TIM O’REILLY. I…
THIS HIT HOME TODAY...... “Pursue something so important that even if you fail, the world is better off with you having tried.” TIM O’REILLY. I…
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Great collaborative work from the teams at Nested Therapeutics and Inductive Bio. Thank you for sharing a real-world, in-practice example of how new…
Great collaborative work from the teams at Nested Therapeutics and Inductive Bio. Thank you for sharing a real-world, in-practice example of how new…
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Proud to be a part of a data-focused, resourceful, biotech company with high integrity and transparency. More exciting company updates to come soon!
Proud to be a part of a data-focused, resourceful, biotech company with high integrity and transparency. More exciting company updates to come soon!
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Dealing with adversity when building startups.
Dealing with adversity when building startups.
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I'm excited to share results and lessons learned from our successful collaboration with Nested Therapeutics!
I'm excited to share results and lessons learned from our successful collaboration with Nested Therapeutics!
Liked by Devon Cayer
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