MedChemExpress LLC

👏👏👏 WoW! Our customers published an article in Nature Biotechnology!   Due to the expansion of population-scale databases to millions of protein-coding variants, the understanding of their mechanistic consequences has lagged behind. 🤩   🔥 🔥 🔥 This article introduced PROD-ATAC, a high-throughput method for discovering the effects of protein-coding variants on chromatin regulation. A pooled variant library was expressed in a disease-agnostic cell line, and a single-cell transposase-accessible chromatin analysis was performed to resolve the impact of each variant on the chromatin landscape. Using PROD-ATAC, we analyzed over 100 oncofusions (cancer-causing chimeric proteins) and their controls, revealing that chromatin remodeling was common across a wide range of fusion frequencies. Furthermore, fusion-induced dysregulation may have been context-agnostic, as the observed mechanisms frequently overlapped with prior knowledge specific to cancer and cell types. This article also demonstrated that gain-of-function activity was prevalent among oncofusions.   ✨ This work begins to outlines a global map of fusion-induced chromatin alterations and suggests the possibility of convergent mechanisms among diverse oncofusions and shared modes of dysregulation present in tumors at different frequencies. PROD-ATAC is generalizable to any set of protein-coding variants.   https://lnkd.in/g5dGsbbS   For more push, please follow #Twitter: https://lnkd.in/gntQ9qE7   Related Product Recommendation:   #Entrectinib (NMS-E628; RXDX-101; https://lnkd.in/gw8hqPAJ);   #DMSO (Dimethyl sulfoxide; https://lnkd.in/ephUV2dZ);   #TritonX100 (https://lnkd.in/gKejxn5T);   #DMEM (DMEM (High Glucose, L-Glutamine, Pyruvate, Phenol Red, no HEPES); https://lnkd.in/gf9UaZ8F)   # NatureBiotechnology #PROD-ATA #Protein-coding #Cancer #MCE #MedChemExpress

🔥 Get the Best Deals of #August 🔥 MedChemExpress LLC North America is thrilled to offer you our best prices ever on a wide selection of high-quality #compounds! If you have any questions, please feel free to contact us at: [email protected] 🌟 Custom Compound Libraries from 💲2.5. 🌟 30% OFF on 8-Channel Handheld Screw Cap Decapper. #event #ScreeningLibraries #customcompoundlibraries #CompoundLibraries #promotion #libraries #research #activity #8ChannelHandheldScrewCapDecapper #MedChemExpress

🤝 MedChemExpress LLC North America thank you for attending yesterday's Icahn School of Medicine at Mount Sinai show. We hope that our information has been useful to you. We look forward to seeing you next time. 🤗   🔽 For More Information： https://lnkd.in/eXGE3XQC   #lifesciences #molecules #research #smallmolecules #university #show #MedChemExpress

🔔 #Antibody：How to Select Primary Antibody，Secondary Antibody and Loading Controls Antibody?

✨ #Bicalutamide is a Competitive Non-#steroidal #AR Antagonist for #Prostate #Cancer Rresearch 🎈 #Androgen receptor (AR) is a type of #nuclear receptor that is activated by binding of either of the #androgenic #hormones testosterone or dihydrotestosterone in the cytoplasm and then translocating into the nucleus. Upon binding the hormone ligand, the receptor dissociates from accessory #proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. The main function of the androgen receptor is as a #DNA-binding transcription factor that regulates gene expression. #Antiandrogens, also known as #androgen antagonists or #testosterone blockers, are a class of drugs that prevent androgens. They act by blocking the androgen receptor (AR) and/or inhibiting or suppressing androgen production. Antiandrogens are used to treat an assortment of androgen-dependent conditions. In men, antiandrogens can be uesd in #prostate #cancer, and enlarged prostate. 🔔 #Bicalutamide is an orally active non-steroidal androgen receptor (AR) antagonist with an #IC50 of 160 nM. #Bicalutamide is an anti-androgen, which competes with androgens for binding AR. Bicalutamide inhibits the growth of prostate cancer by binding to the androgen receptor rather than androgen. Bicalutamide has the potential for prostate cancer research. Bicalutamide also induces the #apoptosis of prostate cancer cells. In #LNCaP #cells, Bicalutamide increases the protein levels of caspase 3. Bicalutamide has an apoptotic effect on #endoplasmic reticulum (ER)-stress via fodrin-mediated apoptosis in LNCaP cells. In the setting of castration-resistant prostate cancer (#CRPC), Bicalutamide undergoes an antagonist-to-agonist switch, stimulating AR activity. In absence of #R1881, Bicalutamide partially activates VP16-AR-mediated transcription, indicative of AR binding to DNA. In VCaP #cells, Bicalutamide induces cell-#proliferation in a dose-dependent manner. Bicalutamide (10 mg/kg; for 28 days) exhibits #anti-tumor activity in prostate cancer #mice #model. In summary, Bicalutamide is an anti-androgen that can be used for the study of prostate cancer. 👉 https://lnkd.in/gyBdMaSj 👉 For more detailed information： https://lnkd.in/g9wwMm7E

📢 July 31 😊MedChemExpress LLC North America will be at the Icahn School of Medicine at Mount Sinai this Wednesday for the show. You can meet us at the show and learn more about MedChemExpress. We look forward to meeting you.🤗   📍 Location: New York Academy of Medicine (NYAM), 1216 Fifth Avenue, New York, NY 10029 📆 Date: July 31, 2024 🕚 11:00AM - 1:00PM 🔽 For More Information: https://lnkd.in/eXGE3XQC

✨ #Cenerimod is an #Orally Active #S1P1 Agonist for #Autoimmune and #Inflammatory Diseases Research. 🎈 The #S1P1 receptor, a #protein that plays a pivotal role in regulating #immune response, interacts with S1P, a #plasma #lipid mediator. Remarkably, S1P regulates an array of physiological phenomena such as #angiogenesis, #inflammation, #immunity, #cell #motility, and #neurotransmitter release. S1PR modulation has emerged an option for patients battling multiple #sclerosis, offering an innovative mechanism of selective #immune sequestration. For example, the advent of #FTY720/Fingolimod, the first nonselective S1P1‐5 receptor modulator, was a breakthrough, demonstrating clinical efficacy in relapsing forms of multiple sclerosis. Reports of #cardiovascular, #hepatic, and respiratory side effects highlighted a need for better alternatives. #Cenerimod, a novel, potent, and selective S1P1 receptor modulator featuring unique signaling properties, while notably negating broncho‐ and vasoconstrictor effects. 🔔 #Cenerimod is an #orally active #S1P1 agonist for #autoimmune and #inflammatory diseases research. In #vitro, Cenerimod has emerged as a highly potent S1P1 receptor agonist. In assays using (35S)-GTPγS and HUVEC cell membrane preparations. It demonstrates an #EC50 of just 2 nM. Cenerimod activates the G #protein and escalates Ca2+ signaling in CHO cells, with EC50s of 1 nM and 124 nM respectively. In an intriguing turn of events, Cenerimod (5 μM, 24 h) effectively inhibits collagen production in #fibroblasts. In #vivo, with a single oral dose of 0.1-10 mg/kg, Cenerimod shows its capabilities by reversibly reducing the number of circulating lymphocytes in #rats. Cenerimod (6 mg/kg, #po., daily for 30 days) remarkably attenuates disease symptoms in an experimental #autoimmune encephalitis (#EAE) mouse model. #Cenerimod (10 mg/kg/day, 42 days) effectively attenuates #skin and lung #fibrosis in Scl-cGVHD #mice. In summary, Cenerimod effectively modulates the function of S1P1 receptor. Cenerimod influences the movement of #lymphocytes – a key factor in the progression of #autoimmune. 👉 https://lnkd.in/gbkFGpCm 👉 For more detailed information: https://lnkd.in/grMGUdSF

✨ #Fatty #acids are components of #cell membranes and play an indispensable role in cell signaling. In addition, #FFAs can be taken up from circulating plasma by all mitochondria-containing cells, and metabolized by β-oxidation and the citric acid cycle to release large amounts of energy in the form of #ATP. Abnormal fatty acid #metabolism is associated with the occurrence and development of #cardiovascular diseases, #diabetes, fatty liver, #hyperthyroidism, and other diseases. If you are interested in conducting research on metabolic-related diseases or lipidomics studies, the Fatty Acids Compound Library (HY-L182) is an excellent choice. 📣 #MCE Raleted #Products: Fatty Acids Compound Library (HY-L182) 👉 https://lnkd.in/g6HU_4NQ 👉 For more detailed information: https://lnkd.in/g7JNbdDT

👏 👏👏Congratulations! Our clients published a paper in Nature Methods!   In the field of cancer therapy, research on the molecular and ular functions of small-molecule inhibitors has garnered significant attention, particularly focusing on their effects targeting genome and epigenome-associated proteins.🤔   🎆 🎆🎆This study introduced the EpiChem technology, which was designed for joint in situ mapping of small molecules and multimodal epigenomic landscapes within single s. In human colorectal cancer (CRC) organoids, this article demonstrated the single- co-assays of three small molecules with histone modifications, chromatin accessibility, or target proteins. These analyses revealed diverse drug interactions within the chromatin states of heterogeneous CRC organoids. Furthermore, the study uncovered the differences in drug-genomic binding dynamics and adaptive epigenomes across types in CRC organoids following small-molecule drug treatment.   🌞 The method presented in this paper offers a unique tool for investigating the mechanisms of type-specific drug actions.   https://lnkd.in/ec7k55bJ   For more push, please follow #Twitter: https://lnkd.in/gntQ9qE7   Related Product Recommendation:   #BiotinylatedJQ1 (Biotin-JQ1; https://lnkd.in/edg63F8W);   #bioTHZ1 (https://lnkd.in/ezFvbNQ4);   #Bovine Serum Albumin (BSA; Albumin bovine serum; https://lnkd.in/guBHkBd9);   #JQ1 ((+)-JQ-1; https://lnkd.in/eRZJpe-T);   #Dox (Doxorubicin (hydrochloride); Hydroxydaunorubicin (hydrochloride); https://lnkd.in/g9MGnrhC);   #THZ1 (https://lnkd.in/exuPyDF4)   #NatMethods #CRC #EpiChem #Cancer #Epigenomes #Drug-genomic #binding # #MCE #MedChemExpress

🔔 Published in #ACS #Infectious #Diseases: This study assessed the potential ability of #adrenergic receptor inhibitors to enhance the #antibacterial activity of polymyxin B (PB) against Klebsiella pneumoniae and determined that dronedarone has the most potent activity both in #vitro and in #vivo. This study found that dronedarone increases the thermal stability of LuxS, decreases the production of AI-2, and affects the biofilm formation of K. pneumoniae. 📣 #Related #Product Recommendation: RT Master Mix for q#PCR II MCE RT Master Mix for qPCR II is a convenient, ready-to-use formulation for reverse transcription. With advanced reverse transcriptase, this kit can synthesize cDNA more rapidly, more specifically. 👉 https://lnkd.in/gkwwCkey 👉 For more detailed information: https://lnkd.in/gbTAbP4E