Uncover the versatility of a single #cellline in dual applications — #targetedproteindegradation & compound #targetengagement. Engineered SPRINTer™ cell lines, readily used for protein turnover & #degrader potency assessments, can now be extended to measure cellular compound target engagement & rank order inhibitor studies. Read the latest #applicationnote describing this dual application that can enable acceleration of degrader discovery & development. Gain insights on characterization of #PROTACs, #molecularglues including effect of different immunomodulatory drugs (#IMiDs), & more.. https://lnkd.in/gAK6qzu7
Eurofins DiscoverX
Biotechnology Research
Fremont, CA 5,036 followers
The Eurofins Discovery Products Company
About us
Eurofins DiscoverX, the products company of Eurofins Discovery, is committed to enabling and accelerating multi-modality drug discovery and development from discovery to QC lot release. For drug discovery and development scientists, Eurofins DiscoverX is the trusted product solutions provider that accelerates research and drug discovery programs with confidence for cytokine receptors, checkpoint receptors, GPCRs, kinases, ion channels, epigenetics, nuclear receptors, and other target families. Eurofins DiscoverX develops and manufactures cutting edge assays, stable cell lines, ready-to-use kits (including bioassays), membrane preps, enzymes, and reagents for small molecule and biologic immuno-oncology, cytotoxicity, compound-target engagement, potency and QC lot release, pharmacotrafficking, and many other applications. These products are developed from 3 R&D and manufacturing centers of excellence – San Francisco Bay Area California (Fremont); St. Louis area, Missouri (St. Charles); and Poitiers, France.
- Website
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http://www.discoverx.com
External link for Eurofins DiscoverX
- Industry
- Biotechnology Research
- Company size
- 51-200 employees
- Headquarters
- Fremont, CA
- Type
- Public Company
- Founded
- 2000
- Specialties
- drug discovery, GPCR, Kinase, Epigenetics, immuno-oncology, phenotypic profiling, cell-based assays, drug discovery products, bioassays, cyotoxicity, cytokine receptors, compound target engagement, custom assay development, and Kinases
Locations
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Primary
Get directions
Fremont, CA 94538, US
Employees at Eurofins DiscoverX
Updates
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Act Fast & Save on KILR® #cytotoxicity products! Accelerate antibody-mediated therapeutic development by employing KILR- the chosen platform for #ADCC, #ADCP, & #CDC assays. Obtain a 40% discount when ordering KILR #Bioassay Kits, Cell Lines, & Cell Pools. SAVE NOW --> https://lnkd.in/gvacJQXn
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Checkout Now & Save on MOA-reflective, functional #cellbasedassays to analyze signaling, dimerization, internalization, & clustering/crosslinking of #checkpointreceptors. Accelerate #immunotherapy drug development. Obtain a 25% discount when ordering Checkpoint Receptor Cell Lines, Bioassay Kits, & eXpress Assay Kits. Checkout now -> https://lnkd.in/g6mJXhHg
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ACT FAST & SAVE on #cytokinereceptor products. Get functional, MOA-reflective assays targeting human cytokine receptors for screening, characterization, QC lot release, & NAb studies. Obtain a 20% discount when ordering Cytokine Receptor #CellLines, #BioassayKits, & eXpress #AssayKits. Save Now--> https://lnkd.in/g7BAX9uN
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Join us to learn about exciting developments including reliable tools for #highthroughput pharmacological #screening of #nAChR a7 #ionchannel target involved in neurological & immune signaling pathways. Register now for the Nov 21st webinar jointly presented by Eurofins DiscoverX's James Costantin & Nanion Technologies's @IIka Rinke-Weiß. https://lnkd.in/dzpxH4cT
𝗪𝗲𝗯𝗶𝗻𝗮𝗿: 𝗥𝗲𝗹𝗶𝗮𝗯𝗹𝗲 𝗔𝗰𝘁𝗶𝘃𝗮𝘁𝗶𝗼𝗻 𝗼𝗳 𝗻𝗔𝗖𝗵𝗥 α𝟳 – 𝗦𝗽𝗲𝗲𝗱, 𝗣𝗿𝗲𝗰𝗶𝘀𝗶𝗼𝗻, 𝗮𝗻𝗱 𝗛𝗶𝗴𝗵 𝗧𝗵𝗿𝗼𝘂𝗴𝗵𝗽𝘂𝘁! The α7 subtype of nicotinic acetylcholine receptors (nAChR α7) is vital for neurological and immune signaling and shows promise for treating Alzheimer’s, schizophrenia, and other disorders. However, nAChR α7 studies face challenges like rapid desensitization and low conductance. 📅 When: November 21, 2024 at 16:00 h CEST Our webinar will showcase: ✔️ 𝗔𝗱𝘃𝗮𝗻𝗰𝗲𝘀 𝗶𝗻 𝘀𝘁𝗮𝗯𝗹𝗲 𝗰𝗲𝗹𝗹 𝗹𝗶𝗻𝗲𝘀: Learn about the Eurofins DiscoverX nAChR α7/ric3 HEK cell line. This line enhances receptor expression, achieving reliable acetylcholine response with positive allosteric modulators (PAMs). ✔️ 𝗩𝗮𝗹𝗶𝗱𝗮𝘁𝗶𝗼𝗻 𝗼𝗳 𝗥𝗲𝗮𝗱𝘆-𝘁𝗼-𝗔𝘀𝘀𝗮𝘆 (𝗥𝗧𝗔) 𝗳𝗿𝗼𝘇𝗲𝗻 𝗰𝗲𝗹𝗹𝘀: These cells eliminate the need for live cultures and deliver consistent results post-thaw. Validation data will highlight successful acetylcholine potentiation with PAMs like PNU-120596 and NS-1738 on SyncroPatch 384. ✔️ 𝗡𝗲𝘄 𝗡𝗣𝗖-𝟯𝟴𝟰𝗧 𝗙/𝗠 𝗦𝗧𝗜𝗠 𝗖𝗵𝗶𝗽: Nanion’s F/M STIM chips deliver superior performance with higher seal resistance, greater current amplitudes, and faster response kinetics, while maintaining consistency in EC50 values for ligands such as acetylcholine, nicotine, and the PAM PNU-120596. Join us at the webinar to get insights from James Costantin (Eurofins DiscoverX) on cell line advancements, and from Ilka Rinke (Nanion Technologies) on enhanced capabilities of the NPC-384T F/M STIM chip on the SyncroPatch 384. 📅 Save your spot and register here: https://lnkd.in/dzpxH4cT #Webinar #Neuroscience #IonChannels #Electrophysiology #DrugDiscovery #APC #SyncroPatch384 #PatchClamp
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Minimize #assaydevelopment time & eliminate lengthy, expensive, & time-consuming cell cultures with #assayready kits. Ensure robust & reliable performance every time by choosing from two assay ready kit formats: eXpress™ & bioassays, that are based on research or #drugdiscoverydevelopment phase. - eXpress Kits: Suited for discovery & basic research including rapid analysis for screening, proof-of-concept, & rank-ordering studies - Bioassay Kits: Suited for characterization studies to commercial release including MOA confirmation, nAb detection, stability, & potency studies through late discovery into clinical release eXplore these formats: https://lnkd.in/d4kr_eK2
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Take advantage & save now on KILR® #cytotoxicity products! Find out for yourself why KILR is the chosen platform for #ADCC, #ADCP, & #CDC assays. Obtain a 40% discount when ordering KILR #Bioassay Kits, Cell Lines, & Cell Pools.. SAVE NOW --> https://lnkd.in/gvacJQXn
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Newly launched!! hCav1.2 RTA frozen cells expand Eurofins DiscoverX®'s portfolio of ready-to-assay (RTA) cardiac #ionchannels (including hNav1.5 & hERG cells) now offering the ability to assess all three #cardiacionchannels (recommended by the FDA) to test against new #drugcandidates. Easily screen & assess #electrophysiologicalpharmacology of cardiac ion channel inhibitors for drug discovery using this complete portfolio of PrecisION™ cardiac ion channel RTA cells. Check out now: https://lnkd.in/gXPHyYCs
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Save now on MOA-reflective, functional #cellbasedassays to analyze signaling, dimerization, internalization, & clustering/crosslinking of #checkpointreceptors. Obtain a 25% discount when ordering Checkpoint Receptor Cell Lines, Bioassay Kits, & eXpress Assay Kits. SAVE NOW --> https://lnkd.in/g6mJXhHg
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Save now on functional, MOA-reflective assays targeting human #cytokinereceptors for screening, characterization, QC lot release, & NAb studies. Obtain a 20% discount when ordering Cytokine Receptor #CellLines, #BioassayKits, & eXpress Assay Kits. ACT FAST & SAVE --> https://lnkd.in/g7BAX9uN
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