Cirsium Biosciences

Partnering with Advanced Research Projects Agency for Health (ARPA-H) for our VECTORS project grant is a significant milestone in realizing our vision for the future of gene therapies. While the benefits of expanding our capabilities and infrastructure are countless, here are four transformative ways this grant allows us to accelerate innovation. 1. Reducing Costs & Speeding Timelines: Through our work with ARPA-H, we will rapidly advance critical research initiatives, including refining our plant-based bioreactor technology to increase efficiency further and reduce production costs for AAV at 10x compared to current methods. 2. Scaling Production Capabilities: Expanding our production facility increases our capacity by more than 5x, allowing us to meet the growing demand for gene therapy products. This scale-up is essential to support large-scale manufacturing as we move toward commercialization. 3. Driving Strategic Collaboration: The grant resources provided through the grant open doors for partnerships with leading experts and organizations seeking innovative approaches in AAV development to launch new therapeutic programs at a lower cost and with shorter timelines. 4. Advancing Patient Access: Our ultimate mission is to improve global access to life-saving gene therapies. This grant allows us to significantly reduce the cost and time to deliver gene therapies to patients, making these treatments more affordable and accessible to those in need. We’re thrilled to share this exciting journey with you and look forward to continuing to transform gene therapy innovation. Stay tuned for updates on leveraging this grant to drive progress! #PlantScience #GeneTherapyManufacturing #ARPAH #ViralVector #AAV

Cirsium is gearing up for the 2024 Cell & Gene Meeting on the Mesa in Phoenix next week! ☀️ We’re excited to dive into the latest advancements in gene therapy and showcase our unique platform, which uses plants as bioreactors to drive innovation. 🌱   This past month has been especially exciting for us. We’ve secured significant funding from ARPA-H for our groundbreaking VECTORS project, which creates new opportunities to accelerate our platform’s development.   Daniel G. and Jake Connors will attend, along with our incoming VP of Business Development, Adam Roose. If you’re attending, let’s connect! We’d love to share how we use this momentum to expand our platform’s technology and explore collaboration opportunities. #CGMesa24 #CellandGeneTherapy #CellTherapy #GeneTherapy Alliance for Regenerative Medicine

We're excited to attend #SfN24 in Chicago this Saturday! Join us as Daniel G. presents our groundbreaking platform, which utilizes plants as bioreactors for scalable and cost-effective AAV production. We look forward to connecting with everyone attending. #AAV #PlantScience #GeneTherapyManufacturing #ViralVector #Chicago #Plants #Bioreactors #AAVVectors

Making AAV in a bioreactor is crazy expensive. But here’s how to make it in plants instead: (At a fraction of the cost) 1. Create plant-specific plasmids for encoding AAV components 2. Transform nanograms of the plasmids into plant bacteria 3. Infiltrate plants with bacteria 4. Bacteria releases plasmid, which kickstarts AAV production in the somatic cells of the leafs 5. Literally “juice” the plants once AAV production concludes (Up till now, none of this needs to be performed in a clean room environment - even when GMP batches are being made). 6. Transfer juice to GMP clean room 7. Perform multi-step clarification 8. Run through TFF filtration 9. Purify AAV with affinity chromatography, Iodixanol gradients or ion exchange chromatography 10. Formulate in your favorite excipient This is much less expensive. As in, 100x less. And the waste is biodegradable. If you’re attending Mesa next week… Let’s chat. You can book a time to meet here using the partnering App: https://lnkd.in/gmtbeqWR #genetherapy #innovation #biotechnology

Join the Cirsium Biosciences team! We’re hiring a Plant Scientist to contribute to our dynamic research group. Learn more and apply at CirsiumBio.com/careers #PlantScientist #Scientist #Hiring #SanDiegoJobs #Biotechnology #BiotechJobs #GeneTherapyManufacturing #PlantScience #SanDiego #AAV #ViralVectors

We’re excited to announce that Cirsium Biosciences has been awarded funding from the ARPA-H Open Broad Agency Announcement (BAA) for our VECTORS project! This award allows us to accelerate the development of our innovative plant-based manufacturing platform, which aims to transform health outcomes across a wide range of diseases and conditions. Thank you to Advanced Research Projects Agency for Health (ARPA-H) for this opportunity. We’re eager to advance gene therapy and contribute to the future of healthcare! Read more about this award: https://lnkd.in/eSbXXR6m #PlantScience #GeneTherapyManufacturing #ARPAH #ViralVector #AAV

🌿 When discussing our plant-based process, we often hear, "So, do you work with real, live plants?" The answer is yes—and it's even more fascinating than you might think. From cultivating plants in our state-of-the-art greenhouses to using them in groundbreaking research, we leverage plants' capabilities to push novel solutions for gene therapy manufacturing. Explore below how we work with plants to drive cutting-edge advancements. #PlantScience #GeneTherapyManufacturing #Biotechnology #AAV #ViralVector

Today begins National Hispanic Heritage Month, observing the Hispanic and Latinx communities' cultures, history, and contributions. We are especially grateful for the profound impact this community has had on advancing the field of science. This article highlights the significant achievements of Hispanic scientists whose contributions have shaped our world. https://lnkd.in/eNhn6u3Y #NationalHispanicHertiageMonth #HispanicHertiage

Daniel G., our CEO, offers a great summary in this video on how our plant-based platform addresses key industry bottlenecks. Thank you for the highlight, Benjamin McLeod!

This may look like an afternoon smoothie, but our "leaf blend" is a crucial part of our AAV production process. 🌿 In this step, AAV-producing leaves are homogenized in a blender and our biologic can be extracted from the leaves for downstream purification. Similar to tissue homogenization, the mechanical shear from the blades ruptures the plant cells and releases our AAVs into solution. #GeneTherapyManufacturing #PlantScience #ViralVector #Plants #AAV