JAMA Senior Editor Derek Angus, MD, MPH, and JAMA Associate Editor Christopher Seymour, MD, MSc, discuss 4 critical care trials published in JAMA and simultaneously presented at the 2024 CCR Down Under meeting in Melbourne, Australia, with JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content: Electronic Sepsis Screening Among Patients Admitted to Hospital Wards Early Restrictive vs Liberal Oxygen for Trauma Patients High-Flow Nasal Oxygen vs Noninvasive Ventilation in Patients With Acute Respiratory Failure Do Sepsis Alerts Help? Reevaluating Respiratory Support in Acute Respiratory Failure—Insights From the RENOVATE Trial and Implications for Practice Is High-Flow Oxygen the Standard for All Patients With Acute Respiratory Failure? Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected Sepsis