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    A Simple Guide to Fibro-sarcoma, Diagnosis, Treatment and Related Conditions
    A Simple Guide to Fibro-sarcoma, Diagnosis, Treatment and Related Conditions
    A Simple Guide to Fibro-sarcoma, Diagnosis, Treatment and Related Conditions
    Ebook144 pages1 hour

    A Simple Guide to Fibro-sarcoma, Diagnosis, Treatment and Related Conditions

    By Kenneth Kee

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    About this ebook

    This book describes Fibro-sarcoma, Diagnosis and Treatment and Related Diseases

    Sarcoma is the cancer that starts in the soft tissues of the body.

    The soft tissues are the connective tissues that maintain everything in place, such as:
    1. Nerves, tendons, and ligaments
    2. Fibrous and deep skin tissues
    3. Blood and lymph vessels
    4. Fat and muscle

    Soft tissue sarcomas consist of more than 50 types.

    Fibro-sarcoma comprises about 5 percent of primary bone sarcomas.

    It is infrequent, involving about 1 in 2 million people.

    Fibro-sarcoma is so named since it is made of malignant spindled fibroblasts or myofibroblasts.

    It has its beginning in the fibrous tissue that encloses tendons, ligaments, and muscles.

    While it can originate in any area of the body, it is most frequent in the legs or trunk.

    Fibro-sarcomas are considered a malignant neoplasm composed of fibroblasts that may have differing quantities of collagen production and having ‘herringbone’ architecture.

    Fibro-sarcomas can be sub-classified into 2 types:
    1. Infantile or congenital fibro-sarcomas, or
    2. Adult-type fibro-sarcomas.

    Infantile fibro-sarcomas seldom metastasize while adult-type fibro-sarcomas are very malignant.

    In infants under the age of 1, it is termed infantile fibro-sarcoma (IFS) and is normally slow-growing.

    Infantile Fibro-sarcoma is a malignant tumor of infancy normally seen in children below age 1.

    The most frequent site of the tumor is the arms and legs followed next by the trunk.

    In older children and adults, it is termed adult form fibro-sarcoma.

    Adult Fibro-sarcoma often involves the deep soft tissues of the extremities, trunk, head, and neck.

    The exact cause of fibro-sarcoma is not known but genetics may play a role.

    Certain factors may raise the danger of developing the disease, such as some inherited disorders:
    Familial adenomatous polyposis
    Li-Fraumeni syndrome
    Neurofibromatosis type 1

    Other risk factors may be:
    Previous radiation therapy
    Certain chemicals, such as thorium dioxide, vinyl chloride, or arsenic
    Lymph edema, a swelling in the arms and legs

    The symptoms of fibro-sarcoma can be faint at first.

    The patient might notice a painless lump or swelling under the skin.

    As it develops, it can disrupt the ability to use the limb.

    If it begins in the abdomen, the patient probably will not notice until it is of significant size.

    Fibro-sarcoma tumors normally vary from 3-8 cm in size.

    Molecular analysis of the tumor is done to detect the fusion of ETV6 and NTRK3 genes; such detection of this particular mutation can help confirm a diagnosis of Infantile Fibro-sarcoma.

    A diagnosis of Fibro-sarcoma is normally established by excluding the possibility of other tumors.

    It is a diagnosis made through exclusion and may involve the imaging tests.

    Contrast-enhanced MRI is the favored method to evaluate tumors of the extremities or pelvis and will provide data of a tumor's size, margins, signal density, degree of necrosis and vascularization.

    If a mass is detected, the only way to confirm fibro-sarcoma is with a biopsy.

    Surgical excision is the main treatment for localized fibro-sarcomas.

    Intramuscular tumors should have a compartmental total excision.

    If there is extra-compartmental growth, or if the tumor has not reach the insertion of the muscle, a wide-surgical resection would be proper, with the aim of obtaining tumor-free margins.

    The prognosis of fibro-sarcomas is poor.

    The 5-year survival rates for high-grade fibro-sarcomas are about 30%

    TABLE OF CONTENT
    Introduction
    Chapter 1 Fibro-sarcoma
    Chapter 2 Causes
    Chapter 3 Symptoms
    Chapter 4 Diagnosis
    Chapter 5 Treatment
    Chapter 6 Prognosis
    Chapter 7 Kaposi Sarcoma
    Chapter 8 Sarcomas
    Epilogue

    LanguageEnglish
    PublisherKenneth Kee
    Release dateFeb 6, 2022
    ISBN9781005158347
    A Simple Guide to Fibro-sarcoma, Diagnosis, Treatment and Related Conditions
    Author

    Kenneth Kee

    Medical doctor since 1972.Started Kee Clinic in 1974 at 15 Holland Dr #03-102, relocated to 36 Holland Dr #01-10 in 2009.Did my M.Sc (Health Management ) in 1991 and Ph.D (Healthcare Administration) in 1993.Dr Kenneth Kee is still working as a family doctor at the age of 74However he has reduced his consultation hours to 3 hours in the morning and 2 hours inthe afternoon.He first started writing free blogs on medical disorders seen in the clinic in 2007 on http://kennethkee.blogspot.com.His purpose in writing these simple guides was for the health education of his patients which is also his dissertation for his Ph.D (Healthcare Administration). He then wrote an autobiography account of his journey as a medical student to family doctor on his other blog http://afamilydoctorstale.blogspot.comThis autobiography account “A Family Doctor’s Tale” was combined with his early “A Simple Guide to Medical Disorders” into a new Wordpress Blog “A Family Doctor’s Tale” on http://ken-med.com.From which many free articles from the blog was taken and put together into 1000 eBooks.He apologized for typos and spelling mistakes in his earlier books.He will endeavor to improve the writing in futures.Some people have complained that the simple guides are too simple.For their information they are made simple in order to educate the patients.The later books go into more details of medical disorders.He has published 1000 eBooks on various subjects on health, 1 autobiography of his medical journey, another on the autobiography of a Cancer survivor, 2 children stories and one how to study for his nephew and grand-daughter.The purpose of these simple guides is to educate patient on health disorders and not meant as textbooks.He does not do any night duty since 2000 ever since Dr Tan had his second stroke.His clinic is now relocated to the Buona Vista Community Centre.The 2 units of his original clinic are being demolished to make way for a new Shopping Mall.He is now doing some blogging and internet surfing (bulletin boards since the 1980's) startingwith the Apple computer and going to PC.The entire PC is upgraded by himself from XT to the present Pentium duo core.The present Intel i7 CPU is out of reach at the moment because the CPU is still expensive.He is also into DIY changing his own toilet cistern and other electric appliance.His hunger for knowledge has not abated and he is a lifelong learner.The children have all grown up and there are 2 grandchildren who are even more technically advanced than the grandfather where mobile phones are concerned.This book is taken from some of the many articles in his blog (now with 740 posts) A Family Doctor’s Tale.Dr Kee is the author of:"A Family Doctor's Tale""Life Lessons Learned From The Study And Practice Of Medicine""Case Notes From A Family Doctor"

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      Book preview

      A Simple Guide to Fibro-sarcoma, Diagnosis, Treatment and Related Conditions - Kenneth Kee

      A

      Simple

      Guide

      To

      Fibro-sarcoma,

      Diagnosis,

      Treatment

      And

      Related Conditions

      By

      Dr Kenneth Kee

      M.B.,B.S. (Singapore)

      Ph.D (Healthcare Administration)

      Copyright Kenneth Kee 2022 Smashwords Edition

      Published by Kenneth Kee at Smashwords.com

      Dedication

      This book is dedicated

      To my wife Dorothy

      And my children

      Carolyn, Grace

      And Kelvin

      This book describes Fibro-sarcoma, Diagnosis and Treatment and Related Diseases which is seen in some of my patients in my Family Clinic.

      (What You Need to Treat Fibro-sarcoma)

      This e-Book is licensed for the personal enjoyment only. This eBook may not be re-sold or given away to other people. If you would like to share this book with another person, please purchase an additional copy for each reader.

      If you’re reading this book and did not purchase it, or it was not purchased for your use only, then please return to Smashwords.com and purchase your own copy.

      Thank you for respecting the hard work of this author.

      Introduction

      I have been writing medical articles for my blog: http://kennethkee.blogspot.com (A Simple Guide to Medical Disorder) for the benefit of my patients since 2007.

      My purpose in writing these simple guides was for the health education of my patients.

      Health Education was also my dissertation for my Ph.D (Healthcare Administration).

      I then wrote an autobiography account of my journey as a medical student to family doctor on my other blog: http://afamilydoctorstale.blogspot.com.

      This autobiography account A Family Doctor’s Tale was combined with my early A Simple Guide to Medical Disorders into a new Wordpress Blog A Family Doctor’s Tale on http://kenkee481.wordpress.com.

      From which many free articles from the blog was taken and put together into 800 eBooks.

      Some people have complained that the simple guides are too simple.

      For their information they are made simple in order to educate the patients.

      The later books go into more details of medical disorders.

      The first chapter is always from my earlier blogs which unfortunately tends to have typos and spelling mistakes.

      Since 2013, I have tried to improve my spelling and writing.

      As I tried to bring the patient the latest information about a disorder or illness by reading the latest journals both online and offline, I find that I am learning more and improving on my own medical knowledge in diagnosis and treatment for my patients.

      My diagnosis and treatment capability has improved tremendously from my continued education.

      Just by writing all these simple guides I find that I have learned a lot from the reviews (good or bad), criticism and advice.

      I am sorry for the repetitions in these simple guides as the second chapters onwards have new information as compared to my first chapter taken from my blog.

      I also find repetition definitely help me and maybe some readers to remember the facts in the books more easily.

      I apologize if these repetitions are irritating to some readers.

      Chapter 1

      Fibro sarcoma

      What is Fibro sarcoma?

      Sarcoma is the cancer that starts in the soft tissues of the body.

      The soft tissues are the connective tissues that maintain everything in place, such as:

      1. Nerves, tendons, and ligaments

      2. Fibrous and deep skin tissues

      3. Blood and lymph vessels

      4. Fat and muscle

      Soft tissue sarcomas consist of more than 50 types.

      Fibro-sarcoma comprises about 5 percent of primary bone sarcomas.

      It is infrequent, involving about 1 in 2 million people.

      Fibro-sarcoma is so named since it is made of malignant spindled fibroblasts or myofibroblasts.

      It has its beginning in the fibrous tissue that encloses tendons, ligaments, and muscles.

      While it can originate in any area of the body, it is most frequent in the legs or trunk.

      Fibro-sarcomas are considered a malignant neoplasm composed of fibroblasts that may have differing quantities of collagen production and having ‘herringbone’ architecture.

      Fibro-sarcomas can be sub-classified into 2 types:

      1. Infantile or congenital fibro-sarcomas, or

      2. Adult-type fibro-sarcomas.

      Infantile fibro-sarcomas seldom metastasize while adult-type fibro-sarcomas are very malignant.

      In infants under the age of 1, it is termed infantile fibro-sarcoma (IFS) and is normally slow-growing.

      Infantile Fibro-sarcoma is a malignant tumor of infancy normally seen in children below age 1.

      The most frequent site of the tumor is the arms and legs followed next by the trunk.

      In older children and adults, it is termed adult form fibro-sarcoma.

      Adult Fibro-sarcoma often involves the deep soft tissues of the extremities, trunk, head, and neck.

      Incidence

      Most cases of Infantile Fibro-sarcoma are observed within the first 12 months of birth; almost all patients have been reported in children younger than 2 years.

      Most cases of Adult Fibro-sarcoma are evident in middle-aged and older adults in the 40-60 year age group (average age of 56 years).

      It can be occasionally observed in older children.

      Both males and females are involved equally.

      All racial and ethnic groups may be involved.

      Adult fibro-sarcomas have shown a decreasing incidence over the past several years as the classification of fibro-sarcoma persistently narrows and other mesenchymal and non-mesenchymal tumors that imitate fibro-sarcomas are more accurately diagnosed.

      What are the causes of fibro-sarcoma?

      Causes

      The exact cause of fibro-sarcoma is not known but genetics may play a role.

      Certain factors may raise the

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