Biointerface

The cephalosporins release behavior from hybrid organic/inorganic nanomaterial has been evaluated. Sol-gel method was used for Fe3O4 nanoparticles synthesis Fe3O4 / oleic acid – core/shell has been prepared under microwave conditions for 10 minutes. The dimensions of Fe3O4/oleic acid nanoparticles were in the 5-20 nm range and they were previously characterized by High Resolution Transmission Electron Microscopy. After 24 hours at 105 oC, hybrid nanomaterial was dispersed in CHCl3, and then added cephalosporins. The cephalosporins deposition concentration on magnetic nanofluid was 0.3 %. The cephalosporin controlled release dynamics from the core/shell was studied by conductometry method and UV-VIS spectrometry. The analytical data confirm a larger retention in the case of the nanostructured support adsorption of all the active compounds. In all cases, at high times - over 4000 seconds the cephalosporins are far off the solubility threshold, which demonstrates that the adsorption in...

Abstract: Intestinal pathogenic Escherichia (E.) coli strains are a major cause of worldwide morbidity and in some cases, mortality. Several pathological types of E. coli have been characterized based on their different virulence genes and also on their pattern of ...

Abstract: Intestinal pathogenic Escherichia (E.) coli strains are a major cause of worldwide morbidity and in some cases, mortality. Several pathological types of E. coli have been characterized based on their different virulence genes and also on their pattern of ...

Abstract: The magnetic targeted drug delivery system is one of the most attractive strategies of delivering drugs to the area of interest. Magnetic drug targeting is based on using magnetic drug carrier particles to selectively deliver drugs to a specific site inside the body ...

Two substituted 1,2,3-triazoles 4 and 6 have been synthesized by the 1,3-dipolar cycloaddition reaction of 4-azido-8-(trifluoromethyl)quinoline 2 with ethyl acetoacetate and acetylacetone, respectively. The reaction of 2 with ethyl acetoacetate afforded 1-[8-(trifluoromethyl)quinolin-4-yl]-5-methyl-1H-1,2,3-triazole-4-carboxylic acid 3 and with acetylacetone afforded 1-{1-[8-(trifluoromethyl)quinolin-4-yl]-5-methyl-1H-1,2,3-triazol-4-yl}ethanone 5. Compound 3 is converted into its corresponding acid hydrazide and then condensed with different aromatic aldehydes to yield Schiff's base, N-[1-arylmethylene]-1-[8-(trifluoromethyl)quinolin-4-yl]-5-methyl-1H-1,2,3-triazole-4-carbohydrazides 4. Compound 5 is condensed with aromatic aldehydes to obtain [1-aryl-4-{1-[8-(trifluoromethyl)quinolin-4-yl]-5-methyl-1H-1,2,3-triazol-4-yl}prop-2-en-1-ones 6. The newly prepared 1,2,3-triazole derivatives 4 and 6 have been characterized by IR, NMR and mass spectral data. These compounds were screened for their antimicrobial activity.

ABSTRACT The chapter describes the state of the art of titanium foam for tissue attachment and, in particular, for the implant osseointegration as final application for the bone tissue reconstruction. The chapter introduces the description of the titanium alloys used for biomedical applications. Next, a section on the processing techniques for the foaming of the titanium or titanium alloys as well as the surface treatments for the control of physical and chemical surface properties is reported. Such overview aims at empathizing the range of technological approaches to obtain functional biomedical foams. Furthermore, a section on methods for endowing titanium surfaces with biomolecules for tissue integration is included. Finally, a survey on the tissue response to the material implantation is presented with a focus on the titanium interfaces previously described.