Lyn

Lyn or LYN may refer to:

A surname, variant of Lynn

In television and film:

In biochemistry:

Inanimate entities:

In other fields:

LYN

Tyrosine-protein kinase Lyn is a protein that in humans is encoded in humans by the LYN gene.

Lyn is a member of the Src family of protein tyrosine kinases, which is mainly expressed in hematopoietic cells, in neural tissues liver, and adipose tissue. In various hematopoietic cells, Lyn has emerged as a key enzyme involved in the regulation of cell activation. In these cells, a small amount of LYN is associated with cell surface receptor proteins, including the B cell antigen receptor (BCR),CD40, or CD19. The abbreviation Lyn is derived from Lck/Yes novel tyrosine kinase, Lck and Yes also being members of the Src kinase family.

Function

Lyn has been described to have an inhibitory role in myeloid lineage proliferation. Following engagement of the B cell receptors, Lyn undergoes rapid phosphorylation and activation. LYN activation triggers a cascade of signaling events mediated by Lyn phosphorylation of tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the receptor proteins, and subsequent recruitment and activation of other kinases including Syk, phosholipase Cγ2 (PLCγ2) and phosphatidyl inositol-3 kinase. These kinases provide activation signals, which play critical roles in proliferation, Ca²⁺ mobilization and cell differentiation. Lyn plays an essential role in the transmission of inhibitory signals through phosphorylation of tyrosine residues within the immunoreceptor tyrosine-based inhibitory motifs (ITIM) in regulatory proteins such as CD22, PIR-B and FCγRIIb1. Their ITIM phosphorylation subsequently leads to recruitment and activation of phosphatases such as SHIP-1 and SHP-1, which further downmodulate signaling pathways, attenuate cell activation and can mediate tolerance. In B cells, Lyn sets the threshold of cell signaling and maintains the balance between activation and inhibition. Lyn thus functions as a rheostat that modulates signaling rather than as a binary on-off switch.

Lyn (singer)

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Lee Se-jin (born on Seoul, South Korea on 9 November 1981) is a South Korean R&B singer known professionally as Lyn. She has released ten full albums to date.

Biography

Lyn was born in Seoul, South Korea on 9 November 1981. She graduated from Seoul High School and attended University of Seoul.

Career

Lyn was first scouted by an agency because of her voice and from there, she first made her debut under her real name, Lee Se-jin, and released an album. The album sold poorly and was barely known. Lyn then took some time off to train vocally. She made a comeback in 2002 under the name Lyn with her supposedly first album Have You Ever Have A Broken Heart?. It was very successful and was able to shoot her up to one of the top R&B female solo singer of the year. After a surprise two years hiatus, Lyn released her second album Can U See The Bright. The album was very successful, surpassing her previous album with her popular single, "사랑했잖아" (Used To Love). Due to its popularity, the song was eventually covered on another successful singer Lee Seung-gi's album, released in late 2006. Lyn released her third album, The Pride of the Morning, on March 7, 2007, and sold 15,358 copies in that month, placing second in the Music Industry Association of Korea's monthly chart. Again, it was a success and was once again reclaim her title as one of the best R&B female singer. Overall her album sold 25,171 copies. Lyn then released more albums afterwards, and did not become very successful, but in 2009 she made a comeback with her 5th album called 'Let Go, Let In, It's a New Day'. In early 2012, she released her 7th album title 'Love Fiction'.

Park "Lyn" June

Park "Lyn" June (Hangul: 박준; born December 21, 1986) is a Terran player and former Warcraft III Orc player from South Korea who is currently playing for Team DK. Lyn was a successful Warcraft III player for the past few years. He is the only player who won almost all of the premier tournaments which include World Cyber Games,Electronic Sports World Cup, BlizzCon and Intel Extreme Masters. Only two premier tournaments which he never got champion are the World e-Sports Games and International E-Sports Festival but he also got the silver medals of World e-Sports Games in 2008 and 2010, and silver medals of International E-Sports Festival in 2007. His total prize money earnings from Warcraft 3 is the second highest in the Warcraft 3 history following the Jang "moon" Jae-ho.

Game style

He is the first player who uses Blade Master as the core hero and collect low price items to increase skills of Blade Master.

E-sport biography

Warcraft III

Lyn started his career in Chinese team World Elite. Then he joined the Swedish team SK-Gaming and Korean team WeMade FOX.

Lynn (name)

Lynn or Lynne is a surname and given name in English speaking countries.

Surname

It has a number of separate derivations:

The earliest recorded instance of the surname is Aedricus de Lenna of King's Lynn (1177).

Given name

As a given name, Lynn is predominantly female. Now it is more popular as a middle name than as a first name. It is also popular as a suffix for female first names, such as Madalyn/Madalynn, Jocelyn/Jocelynn, Ashlyn/Ashlynn and Emmalyn/Emmalynn. In the year 2013, only 90 girls were given the name Lynn in the United States (variant spellings not included), according to Social Security's "Beyond The Top 1000" name lists, available for download on their website.

4Lyn

4Lyn was a rock band from Hamburg, Germany. 4Lyn began their career as Headtrip in 1995 as high schoolers. They recorded demos and played locally, and in 2000 a gig at the Ohrenschmaus Festival in Hamburg got them attention from label scouts. "4Lyn" is an acronym of sorts; 4 is the number of band members, and LYN stands for "Loud Young Nobodies".

They released their debut self-titled record on Universal Records subsidiary Motor Music in 2001, and toured with Papa Roach, Thumb, Therapy?, Cosmotron, and Dredg. They recorded their sophomore effort, Neon, in Denmark, then toured throughout central Europe. They left Motor Music to sign with Edel Music for their third release, Take it as a Compliment, issued in 2004. In 2005 they wrote a theme song entitled "Go Sea Devils" for the Hamburg Sea Devils, a football team. 2007 saw the release of their self-produced album, Compadres.

In January 2008, the band released the album Hello. Then, as a gift to loyal fans, the band released a live album, Live In Hamburg, which could only be purchased through the band's official website (which had gone offline since their breakup; the band's official Facebook page has taken over as their main website).