Aripiprazole lauroxil
Aripiprazole lauroxil (USAN) (brand name Aristada) is a long-acting injectable atypical antipsychotic that was developed by Alkermes. It is an N-acyloxymethyl prodrug of aripiprazole that is administered via intramuscular injection once every four to six weeks for the treatment of schizophrenia. Aripiprazole lauroxil was approved by the U.S. FDA on 5 October 2015.
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Adenosine A2A receptor
The adenosine A2A receptor, also known as ADORA2A, is an adenosine receptor, and also denotes the human gene encoding it.
Structure
This protein is a member of the G protein-coupled receptor (GPCR) family which possess seven transmembrane alpha helices. The crystallographic structure of the adenosine A2A receptor reveals a ligand binding pocket distinct from that of other structurally determined GPCRs (i.e., the beta-2 adrenergic receptor and rhodopsin).
Heteromers
The actions of the A2A receptor are complicated by the fact that a variety of functional heteromers composed of a mixture of A2A subunits with subunits from other unrelated G-protein coupled receptors have been found in the brain, adding a further degree of complexity to the role of adenosine in modulation of neuronal activity. Hetereomers consisting of adenosine A1/A2A, dopamine D2/A2A and D3/A2A, glutamate mGluR5/A2A and cannabinoid CB1/A2A have all been observed, as well as CB1/A2A/D2 heterotrimers, and the functional significance and endogenous role of these hybrid receptors is still only starting to be unravelled.
Budd Rail Diesel Car
The Budd Rail Diesel Car, RDC or Buddliner is a self-propelled diesel multiple unit (DMU) railcar. Between 1949 and 1962, 398 RDCs were built by the Budd Company of Philadelphia, Pennsylvania, United States. The cars were primarily adopted for passenger service in rural areas with low traffic density or in short-haul commuter service, and were less expensive to operate in this context than a traditional diesel locomotive-drawn train with coaches. The cars could be used singly or several coupled together in train sets and controlled from the cab of the front unit. The RDC was one of the few DMU trains to achieve commercial success in North America. RDC trains were an early example of self-contained diesel multiple unit trains, an arrangement now in common use by railways all over the world.
Background
The self-propelled railcar was not a new concept in North American railroading. Beginning in the 1880s railroads experimented with steam-powered railcars on branch lines, where the costs of operating a conventional steam locomotive-hauled set of cars was prohibitive. These cars failed for several reasons: the boiler and engine were too heavy, water and fuel took up too much space, and high maintenance costs eliminated whatever advantage was gained from reducing labor costs. In the 1900s steam railcars gave way to gasoline, led by the McKeen Motor Car Company, which produced 152 between 1905–1917.J. G. Brill sold over 300 "railbuses" in the 1920s. Newcomer Electro-Motive Corporation, working with the Winton Motor Carriage Company, dominated the market at the end of the 1920s but had exited it completely by 1932 as the Great Depression gutted rail traffic.
Ricoh
The Ricoh Company, Ltd. (株式会社リコー, Kabushiki-gaisha Rikō) is a Japanese multinational imaging and electronics company. It was founded by the RIKEN zaibatsu on 6 February 1936 as Riken Sensitized Paper (理研感光紙, Riken Kankōshi). Ricoh's headquarters are located in Ricoh Building in Chūō, Tokyo.
Ricoh produces electronic products, primarily cameras and office equipment such as printers, photocopiers, fax machines, offers Software as a Service (SaaS) document management solutions such as DocumentMall, RicohDocs, document solutions such as GlobalScan, Print&Share and also offers Projectors. In the late 1990s through early 2000s, the company grew to become the largest copier manufacturer in the world. During this time, Ricoh acquired Savin, Gestetner, Lanier, Rex-Rotary, Monroe, Nashuatec, IKON and most recently IBM Printing Systems Division / Infoprint Solutions Company. Although the Monroe brand was discontinued, products continue to be marketed worldwide under the remaining brand names. In 2006, Ricoh acquired the European operations of Danka for $210 million. These operations continue as a stand-alone business unit, under the Infotec brand.
RDC
RDC may refer to:
In transportation:
In science and technology:
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