Ponç or Ponc may refer to:
PON or Pon may refer to:
Pān is the Mandarin pinyin romanization of the East Asian surname 潘. It is listed 43rd in the Song dynasty classic text Hundred Family Surnames. It is romanized as P'an in Wade–Giles; Poon, Pon, or Pun in Cantonese; Phua in Hokkien and Teochew.
潘 is also a common surname in Vietnam and Korea. It is romanized Phan in Vietnamese and Ban or Pan in Korean.
Pan 潘 is the 37th most common surname in mainland China and the 31st most common surname on Taiwan.
None of the romanizations of Pan 潘 appeared among the 1000 most common surnames during the 2000 US census.
As with many Chinese surnames, the origins of the Pan are various and sometimes legendary.
One origin was a clan name taken from a fief north of Shaanxi granted to Ji Sun, a descendant of King Wen of Zhou. Some members descend from Ji Sun himself, others from his vassals.
Another source was a cadet branch of the ruling House of Mi (芈) of the State of Chu during the Spring and Autumn period. Among these Pans, Pan Chong served as regent and advisor for the state of Chu. When King Cheng of Chu decided to make a younger son the crown prince, Pan Chong aided the elder prince Shangchen instead. Shangchen forced King Cheng to commit suicide and ascended the throne as King Mu of Chu. Pan Chong was made the "Royal Tutor".
Paraoxonase 3, also known as PON3, is a protein which in humans is encoded by the PON3 gene.
This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized.
Serum paraoxonase/arylesterase 2 is an enzyme that in humans is encoded by the PON2 gene.
This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described.
Serum paraoxonase/arylesterase 1 (PON1) also known as A esterase , homocysteine thiolactonase or serum aryldialkylphosphatase 1 is an enzyme that in humans is encoded by the PON1 gene. Paraoxonase 1 has esterase and more specifically paraoxonase activity. Serum PON1 is found in all mammalian species studied so far but is not present in the serum of birds, fish and reptiles or in insects. PON1 is the first discovered member of a multigene family also containing PON2 and PON3, the genes for which are located adjacent to each other on chromosome 7.
Human PON1 is a glycoprotein composed of 354 amino acids and has a molecular weight of 43000 Daltons which associates with high-density lipoprotein (HDL, "good cholesterol") in the circulation. Serum PON1 is secreted mainly by the liver although local synthesis occurs in several tissues and PON1 protein is found in almost all tissues. X-ray crystallography has revealed the structure of PON1 to be a 6 bladed propeller with a unique lid structure covering the active site passage and which allows association with HDL. The structure contains 2 calcium ions which are essential for catalytic activity and enzyme stability.