RPA

RPA may refer to:

In Information Technology:

In government:

RPA (TV series)

RPA is an Australian reality television show that is filmed at Royal Prince Alfred Hospital and shows the everyday workings of this major hospital in Sydney, Australia. Premiering in 1995, the programme is based on the British series Jimmy's which was filmed at St James's University Hospital in Leeds.

Format

For the majority of its thirteen-year run, each episode of RPA has run for half an hour. However, its initial 2007 run was broadcast in combined hour-long episodes, and its return later in the year saw it assume a permanent one-hour timeslot. Operations are recorded on camera and the doctors provide commentary as they operate on patients.

A new RPA: Where Are They Now series, begun in 2007, runs for half an hour. It profiles the lives of patients who have previously appeared on RPA, recapping the original stories and showing follow-ups on the patients' lives or deaths following their initial appearance on the programme. Both series are narrated by Max Cullen.

A brand-new series of the medical/observational series aired on the Nine Network in October 2008. Max Cullen will continue to narrate. The program returned in February 2009 for another brand new series.

Replication protein A

Replication protein A (RPA) is a protein that binds to single-stranded DNA in eukaryotic cells. During DNA replication, RPA prevents single-stranded DNA (ssDNA) from winding back on itself or from forming secondary structures. This keeps DNA unwound for the polymerase to replicate it. RPA also binds to ssDNA during the initial phase of homologous recombination, an important process in DNA repair and prophase I of meiosis. Hypersensitivity to DNA damaging agents can be caused by mutations in the RPA gene. Like its role in DNA replication, this keeps ssDNA from binding to itself (self-complementizing) so that the resulting nucleoprotein filament can then be bound by Rad51 and its cofactors. RPA also binds to DNA during the Nucleotide Excision Repair process. This binding stabilizes the repair complex during the repair process. A bacterial homolog is called single-strand binding protein (SSB).

Structure

RPA is a heterotrimer, composed of the subunits RPA1 (70kDa subunit), RPA2 (32kDa subunit) and RPA3 (14kDa subunit). The three RPA subunits contain OB-folds (oligonucleotide/oligosaccharide binding).

RPA (Rubin Postaer and Associates)

RPA is an American advertising and marketing agency headquartered in Santa Monica, California. It was founded in 1986 by Gerry Rubin and Larry Postaer and currently employs approximately 500 associates. RPA has regional offices in Portland, Denver, Dallas, Chicago, Atlanta, Boston and Moorestown.

Services include broadcast and print creative development, TV, print and radio planning and buying, Web development and interactive marketing, e-mail and mobile marketing, search marketing, strategic planning and research, DRTV, collateral development, sales training and event marketing.

RPA billed in excess of $1 billion in 2007. RPA ranked fifth in revenue among U.S. independent advertising agencies in 2006, at $105.2 million (up 5.7% from 2005).

Clients

Recent awards and recognitions

RPA4

Replication protein A 30 kDa subunit is a protein that in humans is encoded by the RPA4 gene.

References

Further reading

Representation of the People Act 1918

The Representation of the People Act 1918 was an Act of Parliament passed to reform the electoral system in the United Kingdom. It is sometimes known as the Fourth Reform Act. This act was the first to include practically all men in the political system and began the inclusion of women.

Background

Even after the passing of the Third Reform Act in 1884, only 60% of male householders over the age of 21 had the vote. Following the horrors of World War I, millions of returning soldiers would still not have been entitled to vote in the long overdue general election. (The previous election had been in December 1910. The Parliament Act 1911 had set the maximum term of a Parliament at five years, but an amendment to the Act postponed the general election to after the war's conclusion.)

British politicians thus faced a crisis. Quite apart from the evident injustice of withholding the vote from the very men who had fought to preserve the British political system and Empire, the overthrow of the centuries-old Romanov monarchy and the Russian nobility in March of the previous year, and the subsequent revolution of workers and soldiers in November, raised the possibility of a similar socialist revolution in Britain.