AML
AML may refer to:
Associations
Computers
Transport
RUNX2
Runt-related transcription factor 2 (RUNX2) also known as core-binding factor subunit alpha-1 (CBF-alpha-1) is a protein that in humans is encoded by the RUNX2 gene. RUNX2 is a key transcription factor associated with osteoblast differentiation.
Function
This protein is a member of the RUNX family of transcription factors and has a Runt DNA-binding domain. It is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Transcript variants of the gene that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing.
Differences in RUNX2 are hypothesized to be the cause of the skeletal differences between modern humans and early humans such as Neanderthals. These differences include a different shape of the skull, a bell-shaped chest in Neanderthals, etc.
Podcasts:
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by Molella
Whistle's Party
by: MolellaAha aha aha aha aha
Ohhhh all the boyfriend beware
Ehi baby what's up? What you doin' tonight?
Oh yeah I'm going down to the Whistle's Party
The man, leave your boyfriend home
and why don't you come with me
because It's the place that's gonna make you feel good
I don't wanna in not
but if you wanna come you just call me, ok?
Ciao baby
In the beginning
in this time to movin to the left and dancing to the
right
we shake our bodies at the discotek
but now is the time to just feel good
Welcome to the place that feels good
Welcome to the place that feels good
Welcome to the place that feels good
Welcome to the place that feels good
Walking down the street I'm thinking about you
I'm thinking all the times the times we're together
if you wanna come with me blow your whistle to the beat
here I am all alone waiting for you to phone
Blow your whistle
let me blow your whistle the whistle
let me blow your whistle the whistle the whistle
let me blow your whistle the whistle
let me blow your whistle the whistle
blow your whistle
Welcome to the place that feels good
Welcome to the place that feels good
Welcome to the place that feels good
Welcome to the place that feels good
I'm walking down the street I'm thinking about you
I'm thinking all the times the times we're together
if you wanna come with me blow your whistle to the beat
here I am all alone waiting for you to phone
Blow your whistle
let me blow your whistle the whistle
let me blow your whistle the whistle the whistle
let me blow your whistle the whistle
let me blow your whistle the whistle
blow your whistle
Blow your whistle
let me blow your whistle the whistle
let me blow your whistle the whistle the whistle
let me blow your whistle the whistle
let me blow your whistle the whistle