Ōuchi clan (大内氏 Ōuchi-shi) was one of the most powerful and important families in Japan during the reign of the Ashikaga shogunate in the 12th to 14th centuries. Their domains, ruled from the castle town of Yamaguchi, comprised six provinces at their height, and the Ōuchi played a major role in supporting the Ashikaga in the Nanboku-cho Wars against the Imperial Court. The Ōuchi remained powerful up until the 1560s, when they became eclipsed by their vassals, the Mōri clan.
Based in Suō Province, towards the western end of Honshū, the Ōuchi were among the primary families to be involved in foreign trade and relations, particularly with China. Following the Ōnin War (1467–1477), a strong rivalry developed between the Ōuchi and the Hosokawa family, who were now in power. The two clashed at Ningbo in 1523, and as a result the Chinese closed Ningbo to Japanese traders. By the time the Ōuchi were again allowed to send a ship a few years later, the trade was dying out. The family's trade with China fully came to an end by 1548, their monopoly broken by merchants from the seaport of Sakai. The Ōuchi also housed the Spanish Jesuit missionary Francis Xavier for a time in 1551.