Ziconotide
Ziconotide (SNX-111; Prialt) is an atypical analgesic agent for the amelioration of severe and chronic pain. Derived from Conus magus (Cone Snail), it is the synthetic form of an ω-conotoxin peptide.
In December 2004 the Food and Drug Administration approved ziconotide when delivered as an infusion into the cerebrospinal fluid using an intrathecal pump system.
Discovery
Ziconotide is derived from the toxin of the cone snail species Conus magus. Scientists have been intrigued by the effects of the thousands of chemicals in marine snail toxins since the initial investigations in the late 1960s by Baldomero Olivera. Olivera, now a professor of biology in the University of Utah, was inspired by accounts of the deadly effects of these toxins from his childhood in the Philippines. Ziconotide was discovered in the early 1980s by University of Utah research scientist Michael McIntosh, when he was barely out of high school and working with Baldomero Olivera.
Ziconotide was developed into an artificially manufactured drug by Elan Corporation. It was approved for sale under the name Prialt by the U.S. Food and Drug Administration on December 28, 2004, and by the European Commission on February 22, 2005. Azur Pharma acquired worldwide rights (except Europe) to Prialt in 2010.
Podcasts:
-
by The Donnas
-
by Liv Kristine
-
by Tom Kimmel
-
by Electric Eel Shock
Skintight
by: The DonnasI saw you standing by the Slurpee machine,
White studded belt and skin tight jeans
I tried to buy you a Hostess Cupcake,
Baby you're so sweet I got a toothache
I wanna take you home with me,
Wine and Dine you with some cable tv,
C'mon now don't be so shy
In those skintight jeans you're my kinda guy
Skintight baby, all right
Turn out the light and take a bite
Skintight - all night
This feels right, and skintight
Skintight baby all right
Skintight - all night
Turn up the music you can make me all right
We're gonna get it
Friday Fun tonight
In the darkness it's not hard to miss
I can't resist; I need your kiss
Skintight baby, all right
Turn out the light and take a bite
Skintight - all night
This feels right, and skintight
Skintight baby all right Skintight - all night
I saw you talkin' to that slut named Star.
She was standin' by the Nacho Bar.
She only likes you 'cause you're in magazines
But I just like you in your skintight jeans
Skintight baby, all right
Turn out the light and take a bite
Skintight - all night
This feels right, and skintight
Skintight baby all right
Skintight - all night