Zeugma (Greek: Ζεῦγμα) is an ancient city of Commagene; located in modern Gaziantep Province, Turkey. It is a historical settlement that is considered among the four most important settlement areas under the reign of the kingdom of Commagene. It was named for the bridge of boats, or zeugma, that crossed the Euphrates river at that location.
Originally, the ancient city of Zeugma was founded as a Greek settlement by Seleucus I Nicator, one of the generals of Alexander the Great, in 300 BC. King Seleucus almost certainly named a city Seleucia after himself; whether this city is, or may be, the city known as Seleucia on the Euphrates or Seleucia at the Zeugma is disputed. The population in the city at its peak was approximately 80,000.
In 64 BC the city was conquered and ruled by the Roman Empire. It is presumed that the shift of the name of the city occurred at that time. Zeugma, means "bridge-passage" or "bridge of boats". During Roman rule, the city became one of the attractions in the region, due to its commercial potential originating from its geo-strategic location because the city was on the Silk Road connecting Antioch to China with a quay or pontoon bridge across the river Euphrates, the border with the Persian Empire until the late second century.