Sulfur oxide
Sulfur oxide refers to many types of sulfur and oxygen containing compounds such as SO, SO2, SO3, S7O2, S6O2, S2O2, etc.
Sulfur oxide (SOx) refers to one or more of the following:
SOX10
Transcription factor SOX-10 is a protein that in humans is encoded by the SOX10 gene.
Function
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development.
In melanocytic cells there is evidence that SOX10 gene expression may be regulated by MITF.
Clinical significance
Mutations in this gene are associated with Waardenburg-Shah, Waardenburg-Hirschsprung disease, and with uveal melanoma .
Interactions
The interaction between SOX10 and PAX3 is studied best in human patients with Waardenburg syndrome, an autosomal dominant disorder which is divided into four different types based upon mutations in additional genes. SOX10 and PAX3 interactions are thought to be regulators of other genes involved in the symptoms of Waardenburg syndrome, particularly MITF which influences the development of melanocytes as well as neural crest formation. MITF expression can be transactivated by both SOX10 and PAX3 to have an additive effect. The two genes have binding sites near one another on the upstream enhancer of the c-RET gene. SOX10 is also thought to target dopachrome tautomerase through a synergistic interaction with MITF which then results in other melanocyte alteration.
SOX4
Transcription factor SOX-4 is a protein that in humans is encoded by the SOX4 gene.
Function
This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein.
Sox4 is expressed in lymphocytes (B and T) and is required for B lymphocyte development.
Interactions
SOX4 has been shown to interact with SDCBP.
See also
References
Further reading
External links
Zabadak (song)
"Zabadak" is the name of a hit song by the British musical group Dave Dee, Dozy, Beaky, Mick and Tich, written by Ken Howard and Alan Blaikley. It was featured on the 1967 Boxing Day episode of Top of the Pops.
The song has been covered by several artists, among them The Sorrows on a single produced for the Italian market.
The song uses African style percussion (despite nonsense lyric) and was typical of the group's dabbling with other world styles of music, the Latin style of "Save Me" and the Greek style of "Bend It", which made DDDBMT among the more distinctive mid-1960s groups.
Chart positions
References
External links
Podcasts:
