This article is an orphan, as few or no other articles link to it. Please introduce links to this page from related articles; suggestions may be available. (January 2012)

Zinc finger, ZZ-type containing 3
Rendering based on PDB 2FC7.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2FC7, 2YUM
Identifiers
Symbols	ZZZ3; ATAC1
External IDs	HomoloGene: 9182 GeneCards: ZZZ3 Gene
Gene Ontology Molecular function • DNA binding • zinc ion binding • metal ion binding Cellular component • nucleus Biological process • regulation of transcription, DNA-dependent Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	26009	108946
Ensembl	ENSG00000036549	ENSMUSG00000039068
UniProt	Q8IYH5	Q6KAQ7
RefSeq (mRNA)	NM_015534.4	NM_001080755.1
RefSeq (protein)	NP_056349.1	NP_001074224.1
Location (UCSC)	Chr 1: 78.03 – 78.15 Mb	Chr 3: 152.06 – 152.13 Mb
PubMed search	[1]	[2]
This box: view talk edit

ZZ-type zinc finger-containing protein 3 is a protein that in humans is encoded by the ZZZ3 gene.^[1]

Model organisms [link]

Model organisms have been used in the study of ZZZ3 function. A conditional knockout mouse line, called Zzz3^{tm1a(EUCOMM)Wtsi[5][6]} was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.^[7][8][9]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.^[3][10] Twenty four tests were carried out on mutant mice and two significant abnormalities were observed.^[3] No homozygous mutant embryos were identified during gestation, and therefore none survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice and no further abormal phenotypes were identified.^[3]

References [link]

Further reading [link]

This article on a gene on chromosome 1 is a stub. You can help Wikipedia by expanding it. v t e