TCAP

TCAP may refer to:

See also

Telethonin

Telethonin, also known as Tcap, is a protein that in humans is encoded by the TCAP gene. Telethonin is expressed in cardiac and skeletal muscle at Z-discs and functions to regulate sarcomere assembly, T-tubule function and apoptosis. Telethonin has been implicated in several diseases, including limb-girdle muscular dystrophy, hypertrophic cardiomyopathy, dilated cardiomyopathy and idiopathic cardiomyopathy.

Structure

Telethonin is a 19.0 kDa protein composed of 167 amino acids. Telethonin has a unique β-sheet structure, which enables antiparallel association with the Titin Z1-Z2 domains in cardiac and skeletal muscle. Structural analysis of full-length Telethonin with the N-terminal region of Titin indicate that the C-terminus of Telethonin is critical for the dimerization of two Telethonin/Titin complexes into a higher oligomeric structure.

Function

Telethonin expression is developmentally regulated in both cardiac and skeletal muscle and is thought to be critical to sarcomere assembly. Telethonin was found to be a late assembling protein only present in mature myofibrils at Z-discs.

Yerba mate

Yerba mate (from Spanish [ˈʝerβa ˈmate]; Portuguese: erva-mate [ˈɛɾvɐ ˈmate] or [ˈɛɾvɐ ˈmatʃɪ]) is a species of the holly family (Aquifoliaceae), with the botanical name Ilex paraguariensis A. St.-Hil. named by the French botanist Auguste François César Prouvençal de Saint-Hilaire.

Yerba mate is widely known as the source of the beverage called mate (Portuguese: chimarrão, tererê/tereré and other variations). It is traditionally consumed in central and southern regions of South America, particularly Argentina, Bolivia, southern and center-western Brazil, Uruguay, Paraguay and southern Chile. It is also very popular in Syria where it is imported from Argentina. Yerba mate was initially utilized and cultivated by the Guaraní people and in some Tupí communities in southern Brazil, prior to European colonization. It was scientifically classified by the Swiss botanist Moses Bertoni, who settled in Paraguay in 1895. Yerba mate can also be found in various energy drinks on the market today.