Yy1

YY1 transcription factor

PDB rendering based on 1ubd.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1UBD, 1ZNM

Identifiers

Symbols

YY1; DELTA; INO80S; NF-E1; UCRBP; YIN-YANG-1

External IDs

OMIM: 600013 MGI: 99150 HomoloGene: 2556 GeneCards: YY1 Gene

Gene Ontology
Molecular function	• four-way junction DNA binding • DNA binding • sequence-specific DNA binding transcription factor activity • transcription coactivator activity • transcription corepressor activity • RNA binding • protein binding • zinc ion binding • transcription regulatory region DNA binding • metal ion binding
Cellular component	• intracellular • nucleus • transcription factor complex • plasma membrane • nuclear matrix • Ino80 complex • PcG protein complex
Biological process	• negative regulation of transcription from RNA polymerase II promoter • double-strand break repair via homologous recombination • DNA repair • DNA recombination • regulation of transcription from RNA polymerase II promoter • RNA localization • response to DNA damage stimulus • spermatogenesis • anterior/posterior pattern specification • response to UV-C • cell differentiation • cellular response to UV • camera-type eye morphogenesis • chromosome organization
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 14:
100.7 – 100.75 Mb

Chr 12:
110.03 – 110.05 Mb

PubMed search

[1]

[2]

Transcriptional repressor protein YY1 is a protein that in humans is encoded by the YY1 gene.^[1]^[2]

YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. Hence, the YY in the name standing for "yin-yang." YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1.^[3]

1 Interactions
2 References
3 Further reading
4 External links

Interactions [link]

YY1 has been shown to interact with Histone deacetylase 2,^[4]^[5]^[6] FKBP3,^[7] ATF6,^[8] Myc,^[9] SAP30,^[10] EP300,^[5]^[11] HDAC3,^[4]^[5] NOTCH1^[12] and RYBP.^[13]

References [link]

^ Shi Y, Seto E, Chang LS, Shenk T (November 1991). "Transcriptional repression by YY1, a human GLI-Kruppel-related protein, and relief of repression by adenovirus E1A protein". Cell 67 (2): 377–88. DOI:10.1016/0092-8674(91)90189-6. PMID 1655281.
^ Zhu W, Lossie AC, Camper SA, Gumucio DL (July 1994). "Chromosomal localization of the transcription factor YY1 in the mouse and human". Mamm Genome 5 (4): 234–6. DOI:10.1007/BF00360552. PMID 7912122.
^ "Entrez Gene: YY1 YY1 transcription factor". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7528.
^ ^a ^b Yang, W M; Yao Y L, Sun J M, Davie J R, Seto E (October 1997). "Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family". J. Biol. Chem. (UNITED STATES) 272 (44): 28001–7. DOI:10.1074/jbc.272.44.28001. ISSN 0021-9258. PMID 9346952.
^ ^a ^b ^c Yao, Y L; Yang W M, Seto E (September 2001). "Regulation of Transcription Factor YY1 by Acetylation and Deacetylation". Mol. Cell. Biol. (United States) 21 (17): 5979–91. DOI:10.1128/MCB.21.17.5979-5991.2001. ISSN 0270-7306. PMC 87316. PMID 11486036. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=87316.
^ Kalenik, J L; Chen D, Bradley M E, Chen S J, Lee T C (February 1997). "Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1". Nucleic Acids Res. (ENGLAND) 25 (4): 843–9. DOI:10.1093/nar/25.4.843. ISSN 0305-1048. PMC 146511. PMID 9016636. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=146511.
^ Yang, W M; Yao Y L, Seto E (September 2001). "The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1". EMBO J. (England) 20 (17): 4814–25. DOI:10.1093/emboj/20.17.4814. ISSN 0261-4189. PMC 125595. PMID 11532945. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=125595.
^ Li, M; Baumeister P, Roy B, Phan T, Foti D, Luo S, Lee A S (July 2000). "ATF6 as a Transcription Activator of the Endoplasmic Reticulum Stress Element: Thapsigargin Stress-Induced Changes and Synergistic Interactions with NF-Y and YY1". Mol. Cell. Biol. (UNITED STATES) 20 (14): 5096–106. DOI:10.1128/MCB.20.14.5096-5106.2000. ISSN 0270-7306. PMC 85959. PMID 10866666. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=85959.
^ Shrivastava, A; Saleque S, Kalpana G V, Artandi S, Goff S P, Calame K (Dec. 1993). "Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc". Science (UNITED STATES) 262 (5141): 1889–92. DOI:10.1126/science.8266081. ISSN 0036-8075. PMID 8266081.
^ Huang, Nu En; Lin Ching Hui, Lin Young Sun, Yu Winston C Y (June 2003). "Modulation of YY1 activity by SAP30". Biochem. Biophys. Res. Commun. (United States) 306 (1): 267–75. DOI:10.1016/S0006-291X(03)00966-5. ISSN 0006-291X. PMID 12788099.
^ Lee, J S; Galvin K M, See R H, Eckner R, Livingston D, Moran E, Shi Y (May 1995). "Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300". Genes Dev. (UNITED STATES) 9 (10): 1188–98. DOI:10.1101/gad.9.10.1188. ISSN 0890-9369. PMID 7758944.
^ Yeh, Tien-Shun; Lin Yu-Min, Hsieh Rong-Hong, Tseng Min-Jen (October 2003). "Association of transcription factor YY1 with the high molecular weight Notch complex suppresses the transactivation activity of Notch". J. Biol. Chem. (United States) 278 (43): 41963–9. DOI:10.1074/jbc.M304353200. ISSN 0021-9258. PMID 12913000.
^ García, E; Marcos-Gutiérrez C, del Mar Lorente M, Moreno J C, Vidal M (June 1999). "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1". EMBO J. (ENGLAND) 18 (12): 3404–18. DOI:10.1093/emboj/18.12.3404. ISSN 0261-4189. PMC 1171420. PMID 10369680. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171420.

External links [link]

FactorBook YY1

PDB gallery

1ubd: CO-CRYSTAL STRUCTURE OF HUMAN YY1 ZINC FINGER DOMAIN BOUND TO THE ADENO-ASSOCIATED VIRUS P5 INITIATOR ELEMENT

Transcription factors and intracellular receptors

(1) Basic domains

(1.1) Basic leucine zipper (bZIP)	Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) · AP-1 (c-Fos, FOSB, FOSL1, FOSL2, JDP2, c-Jun, JUNB, JUND) · BACH (1, 2) · BATF · BLZF1 · C/EBP (α, β, γ, δ, ε, ζ) · CREB (1, 3, L1) · CREM · DBP · DDIT3 · GABPA · HLF · MAF (B, F, G, K) · NFE (2, L1, L2, L3) · NFIL3 · NRL · NRF (1, 2, 3) · XBP1

(1.2) Basic helix-loop-helix (bHLH)	ATOH1 · AhR · AHRR · ARNT · ASCL1 · BHLH (2, 9) · BMAL (ARNTL, ARNTL2) · CLOCK · EPAS1 · FIGLA · HAND (1, 2) · HES (5, 6) · HEY (1, 2, L) · HES1 · HIF (1A, 3A) · ID (1, 2, 3, 4) · LYL1 · MESP2 · MXD4 · MYCL1 · MYCN · Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) · Neurogenins (1, 2, 3) · NeuroD (1, 2) · NPAS (1, 2, 3) · OLIG (1, 2) · Pho4 · Scleraxis · SIM (1, 2) · TAL (1, 2) · Twist · USF1

(1.3) bHLH-ZIP	AP-4 · MAX · MITF · MNT · MLX · MXI1 · Myc · SREBP (1, 2)

(1.4) NF-1	NFI (A, B, C, X) · SMAD (R-SMAD (1, 2, 3, 5, 9) - I-SMAD (6, 7) - 4)

(1.5) RF-X	RFX (1, 2, 3, 4, 5, 6, ANK)

(1.6) Basic helix-span-helix (bHSH)	AP-2 (α, β, γ, δ, ε)

(2) Zinc finger DNA-binding domains

(2.1) Nuclear receptor (Cys₄)	subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) subfamily 3 (Steroid hormone (Androgen, Estrogen (α, β), Glucocorticoid, Mineralocorticoid, Progesterone), Estrogen related (α, β, γ)) subfamily 4 NUR (NGFIB, NOR1, NURR1) · subfamily 5 (LRH-1, SF1) · subfamily 6 (GCNF) · subfamily 0 (DAX1, SHP)

(2.2) Other Cys₄	GATA (1, 2, 3, 4, 5, 6) · MTA (1, 2, 3) · TRPS1

(2.3) Cys₂His₂	General transcription factors (TFIIA, TFIIB, TFIID, TFIIE (1, 2), TFIIF (1, 2), TFIIH (1, 2, 4, 2I, 3A, 3C1, 3C2)) ATBF1 · BCL (6, 11A, 11B) · CTCF · E4F1 · EGR (1, 2, 3, 4) · ERV3 · GFI1 · GLI-Krüppel family (1, 2, 3, REST, S2, YY1) · HIC (1, 2) · HIVEP (1, 2, 3) · IKZF (1, 2, 3) · ILF (2, 3) · KLF (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 17) · MTF1 · MYT1 · OSR1 · PRDM9 · SALL (1, 2, 3, 4) · SP (1, 2, 4, 7, 8) · TSHZ3 · WT1 · Zbtb7 (7A, 7B) · ZBTB (11, 16, 17, 20, 32, 33, 40) · zinc finger (3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 300, 318, 330, 346, 350, 365, 366, 384, 423, 451, 452, 471, 593, 638, 644, 649, 655)

(2.4) Cys₆	HIVEP1

(2.5) Alternating composition	AIRE · DIDO1 · GRLF1 · ING (1, 2, 4) · JARID (1A, 1B, 1C, 1D, 2) · JMJD1B

(3) Helix-turn-helix domains

(3.1) Homeodomain	ARX · CDX (1, 2) · CRX · CUTL1 · DBX (1, 2) · DLX (3, 4, 5) · EMX (1, 2) · EN (1, 2) · FHL (1, 2, 3) · HESX1 · HHEX · HLX · Homeobox (A1, A2, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C12, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) · HOPX · IRX (1, 2, 3, 4, 5, 6, MKX) · LMX (1A, 1B) · MEIS (1, 2) · MEOX2 · MNX1 · MSX (1, 2) · NANOG · NKX (2-1, 2-2, 2-3, 2-5, 3-1, 3-2, 6-1, 6-2) · NOBOX · PBX (1, 2, 3) · PHF (1, 3, 6, 8, 10, 16, 17, 20, 21A) · PHOX (2A, 2B) · PITX (1, 2, 3) · POU domain (PIT-1, BRN-3: A, B, C, Octamer transcription factor: 1, 2, 3/4, 6, 7, 11) · OTX (1, 2) · PDX1 · SATB2 · SHOX2 · SIX (1, 2, 3, 4, 5) · VAX1 · ZEB (1, 2)

(3.2) Paired box	PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)

(3.3) Fork head / winged helix	E2F (1, 2, 3, 4, 5) · FOX proteins (A1, A2, A3, C1, C2, D3, D4, E1, E3, F1, G1, H1, I1, J1, J2, K1, K2, L2, M1, N1, N3, O1, O3, O4, P1, P2, P3, P4)

(3.4) Heat Shock Factors	HSF (1, 2, 4)

(3.5) Tryptophan clusters	ELF (2, 4, 5) · EGF · ELK (1, 3, 4) · ERF · ETS (1, 2, ERG, SPIB) · ETV (1, 4, 5, 6) · FLI1 · Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) · MYB · MYBL2

(3.6) TEA domain	transcriptional enhancer factor (1, 2, 3, 4)

(4) β-Scaffold factors with minor groove contacts

(4.1) Rel homology region	NF-κB (NFKB1, NFKB2, REL, RELA, RELB) · NFAT (C1, C2, C3, C4, 5)

(4.2) STAT	STAT (1, 2, 3, 4, 5, 6)

(4.3) p53	p53 · TBX (1, 2, 3, 5, 19, 21, 22, Brachyury, TBR1, TBR2) · TP63

(4.4) MADS box	Mef2 (A, B, C, D) · SRF

(4.6) TATA binding proteins	TBP · TBPL1

(4.7) High-mobility group	BBX · HMGB (1, 2, 3, 4) · HMGN (1, 2, 3, 4) · HNF (1A, 1B) · LEF1 · SOX (1, 2, 3, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14, 15, 18, 21) · SRY · SSRP1 · TCF (3, 4) · TOX (1, 2, 3, 4)

(4.9) Grainyhead	TFCP2

(4.10) Cold-shock domain	CSDA, YBX1

(4.11) Runt	CBF (CBFA2T2, CBFA2T3, RUNX1, RUNX2, RUNX3, RUNX1T1)

(0) Other transcription factors

(0.2) HMGI(Y)	HMGA (1, 2) · HBP1

(0.3) Pocket domain	Rb · RBL1 · RBL2

(0.5) AP-2/EREBP-related factors	Apetala 2 · EREBP · B3

(0.6) Miscellaneous	ARID (1A, 1B, 2, 3A, 3B, 4A) · CAP · IFI (16, 35) · MLL (2, 3, T1) · MNDA · NFY (A, B, C) · Rho/Sigma

see also transcription factor/coregulator deficiencies
B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)

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Contents

Interactions [link]

References [link]

Further reading [link]

External links [link]

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