YWHAE

14-3-3 protein epsilon is a protein that in humans is encoded by the YWHAE gene.

Function

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer.

Interactions

YWHAE has been shown to interact with:

  • C-Raf,
  • CDC25B,
  • HDAC4,
  • HERG,
  • IRS1 and
  • IGF1R,
  • MAP3K3,
  • NDEL1,
  • NGFRAP1, and
  • TGF beta 1.
  • See also

  • 14-3-3 protein
  • References

    Further reading

    Podcasts:

    PLAYLIST TIME:

    Steady Risin'

    by: Yo Yo

    [Chorus]
    I been on the low for a while, but now
    It's time to rise up, so open your eyes up
    And recognise the real, that's all up in your grill
    Yo Yo gots the flow, y'all niggas know the deal [x2]
    [Verse 1]
    It's a must that I thrush world plush a little lush money
    Green like sus-money, cream and takes the bus
    International connects, plus discuss the hush-hush
    West-side, Who Ride?, World-wide, Bomb-rush
    So what's the deal with all this 'keep it real' rapping
    I'm still flexing skills, collect my mill and keep stepping
    Pack a weapon close if I ghost a nigga then I'm Swayze
    Cause rapping pays me to live shady, wilin' crazy
    Just the killer Cali lady, snatch your fuckin lady
    If rappers be board, you niggas still couldn't play me
    So save the drama for your mommy and your poppy
    When I hit the track up a mad truck couldn't stop me
    To all you, Versace wearin' Donna Karen tricks
    Starin' all up in my grill, I'ma let you know the deal
    I'm still droppin' bombs like Sudam Husain
    Who-Bang, like Mack-10, sip gin and kick game
    [Chorus]
    [Verse 2]
    I've been on the low, but now it's time to show and prove
    Turn my dues to power moves, I got 'em winning never lose
    So whoever snooze, on the Y-O-Y-O better buy you
    A superior plot, I'm blowin' up the spot
    Hip-Hop's the mil-ticket, and I still kick it
    For my niggas in the hood, best believe it's all good
    My game is understood from LA to Amsterdam
    So I organise my fam' and rock the world like Pearl Jam
    This girl's a thriller, got more game than Shirl' Miller
    And as this world turns, my main concern is earnin' scrilla
    I'm realer than most don't test this west coast fever
    On your reciever, with more respect than Aretha
    Franklin, got mo' bankin', drudge and wheezy
    I'm movin on up so give it up this shit ain't easy
    But see I, step to my B I and be fly
    Like a sparrow, but their all stackin' up 'Genaro
    [Chorus]
    [Verse 3]
    You best rocognise game about the things that I told
    Everything that glitters an't gold, but this mic I hold
    Is worth about a million, really don't peep the flow
    I generate more pace than Wall Street when I blow
    You know this how we do, in killer Cali rule
    Mic check, one two, when the Yo be comin' through
    With the lyrical, verbal miracle, oh Jesus
    I say what I want and I do as I pleases
    For any nigga step in my direction and question
    My affection for this game that I be flexin'
    The same as chin-checkin, I'll be right there like demolition
    I'm on a mission, so just listen
    I'm spittin', the game related, that keep you faded
    Intoxicated, then your pocket get raided
    I made it, for them G's and Ladies
    Beneath the palm trees just shootin' the breeze
    [Chorus]
    That's the way, uh uh, we like it
    Bad as I wanna be, you don't wanna step to me
    That's the way, uh uh, we like it
    Steady Risin' to the top, movin' up another notch [x2]




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