Xylamidine
Xylamidine is a drug which acts as an antagonist at the 5HT2A receptor, and to a lesser extent at the 5HT1A receptor. It does not cross the blood–brain barrier, which makes it useful for blocking peripheral serotonergic responses like cardiovascular and gastrointestinal effects, without producing the central effects of 5HT2A blockade such as sedation, or interfering with the central actions of 5HT2A agonists.
Synthesis
Xylamidine is an amidine which serves as a serotonin inhibitor. This agent is prepared by alkylation of 3-methoxyphenol (m-methoxyphenol) with α-chloropropionitrile, KI and potassium carbonate in MEK to give #, which is in turn reduced with lithium aluminum hydride to give the primary amine #. When # is treated with m-tolylacetonitrile in the presence of anhydrous HCl, the synthesis is completed. Alternately, one can react primary amine # with m-tolylacetamidine under acid catalysis to produce xylamidine.
References
Podcasts:
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by Tina Arena
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by Joseph Arthur
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by Kind Of Like Spitting
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by Shelby Lynne
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by Default
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by Aberfeldy
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by Jaydee Bixby
Soulmate No. 9
by: Tina ArenaSoulmate No.9
Say that I'm the only one
But I know that's just a lie
I'm your Soulmate No. 9
You're living in a fantasy, in your mind
Woah woah woah woah
You live in a made up world
You think that I don't see
It's a world of make believe
You spin a tangled web
Just like a fairytale
It's all in your head
You promised me the world
You promised me the sun light of sunrise
You promised me heaven
But your gonna turn it round
'Cause Soulmate No.9
Say that I'm the only one
But I know that's just a lie
I'm your Soulmate No. 9
You're living in a fantasy, in your mind
Soulmate No. 9
You say you're a grown up man
You've got it in control, your pockets lined in gold
That's not what I need from you
It's never what you say
It's only what you do
You look into my eyes
You try to hypnotise
You say that it's forever
But forever means goodbye
I would have loved you
If you'd just be who you are
If you just say that you want me
And let the feeling feel so real
I feel you, coming from the heart
Soulmate No. 9