Ago

Ago or AGO may refer to:

People

Places

Other uses

Argonaute

The Argonaute protein family plays a central role in RNA silencing processes, as essential catalytic components of the RNA-induced silencing complex (RISC). RISC complex is responsible for the gene silencing phenomenon known as RNA interference (RNAi). Argonaute proteins bind different classes of small non-coding RNAs, including microRNAs (miRNAs), small interfering RNAs (siRNAs) and Piwi-interacting RNAs (piRNAs). Small RNAs guide Argonaute proteins to their specific targets through sequence complementarity (base pairing), which then leads to mRNA cleavage or translation inhibition.

Discovery

The RNA interference (RNAi) was first reported in 1995 by Guo and Kemphues, and similar pathways collectively referred to as RNA silencing were discovered in plants and fungi. The beginning of people’s understanding of the mechanism of RNA silencing began only in 1998 with the experiments of Fire and colleagues demonstrating that double-stranded RNA triggered RNAi. RNA silencing pathways process long RNAs into small RNAs that direct the repression of transcription or translation of nucleic acid targets with sequence corresponding to the small RNAs. These single-stranded RNAs, referred to as guide strands, are incorporated into RNA silencing effectors complexes such as the RNA-induced silencing complex (RISC). These RNA silencing effector complexes contain Argonaute family proteins.

Xpander

Xpander may refer to:

See also

Xpander (album)

Xpander is a 1999 EP by Sasha along with Charlie May, Andy Page (producer) and Gaëtan Schurrer. This single was featured on many compilations such as Global Underground: Ibiza, Pete Tong's Essential Selection, Hooj Choons' Nu Progressive Era, and many other DJ mix compilations. It is considered a seminal release within the Progressive Trance community. It was voted the 9th best Dance track of all time, by readers of Mixmag.

The track is in some ways a tribute to the Oberheim Xpander synthesizer, which is the main synthesizer used in the track.

This track was also featured on the PlayStation game Wipeout 3.

Track listing

References

External links