XPB
XPB (xeroderma pigmentosum type B) is an ATP-dependent DNA helicase in humans that is a part of the TFIIH transcription factor complex.
Structure
The 3D-structure of the archaeal homolog of XPB has been solved by X-ray crystallography by Dr. John Tainer and his group at The Scripps Research Institute.
Function
XPB plays a significant role in normal basal transcription, transcription coupled repair (TCR), and nucleotide excision repair (NER). Purified XPB has been shown to unwind DNA with 3’-5’ polarity.
Disorders
Mutations in XPB and other related complementation groups, XPA-XPG, leads to a number of genetic disorders such as Xeroderma pigmentosum, Cockayne's syndrome, and trichothiodystrophy.
Interactions
XPB has been shown to interact with:
See also
References
Further reading
External links
Podcasts:
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'Diskathing
by: SubbYou may not care but don't be naive
Well take The best The positive aspect
Have some friends and a punkska band
I guess that's The key to your sobriety
Even if you're a pervert use your head
Before you date this girl, you better sure you've bled
It's o.k. you'll do some mistakes
Like Ace Ventura with Snowflakes
Ohhhhhhhhhhhhhh!
Life is like diskathing
And someday you'll have a lovely wife
You'll do like O.J. and kill her with a knife
You'll obey to your bastard dog
Live across The street from a big fat slob
You will be a fucking statistic
Another man without a diploma
But after all you'll be happy
Cause you know man, this is The key
[Chorus]
[Bridge]
[Solo]
Ba-ba-ba, ba-Barbara ann!!! [x3]
[Chorus]