2AM (Adrian Marcel song)
"2AM" is a song by American singer Adrian Marcel. It was released on February 4, 2014, as his commercial debut single. The song features a guest verse from California-based rapper Sage the Gemini and was produced by Chrishan.
Composition
According to Ryan Dombal of Pitchfork Media, the beat of "2AM" consists of four synth notes with "standard-grade ratchet drums".
Charts
Certifications
References
Winter
Winter is the coldest season of the year in polar and temperate climates, between autumn and spring. Winter is caused by the axis of the Earth in that hemisphere being oriented away from the Sun. Different cultures define different dates as the start of winter, and some use a definition based on weather. When it is winter in the Northern Hemisphere, it is summer in the Southern Hemisphere, and vice versa. In many regions, winter is associated with snow and freezing temperatures. The moment of winter solstice is when the sun's elevation with respect to the North or South Pole is at its most negative value (that is, the sun is at its farthest below the horizon as measured from the pole), meaning this day will have the shortest day and the longest night. The earliest sunset and latest sunrise dates outside the polar regions differ from the date of the winter solstice, however, and these depend on latitude, due to the variation in the solar day throughout the year caused by the Earth's elliptical orbit (see earliest and latest sunrise and sunset).
Winter (Tori Amos song)
"Winter" is a song by American singer-songwriter and musician Tori Amos, first released in 1992. The song was written about Amos' relationship with her father, who is a minister.
Release history
"Winter" was first released as the fourth single from Amos' debut studio album Little Earthquakes. It was released on March 9, 1992 by EastWest Records in the UK and Atlantic Records on November 24 in North America.
The song also appears on Amos' 2003 compilation, Tales of a Librarian. The music video can be seen on the two currently available video collections: Tori Amos: Complete Videos 1991–1998 and Fade to Red.
The single was released globally in a variety of formats with slightly differing artwork and track listings. The most commonly available version is the United States release, which is labeled as a "limited edition" release. That version comes in a digipak case with a compartment in which a "handwritten lyrics" insert is contained. The far more rare UK limited edition release features covers that would later appear on the Crucify EP which was released in the United States.
The Four Seasons (Vivaldi)
The Four Seasons (Italian: Le quattro stagioni) is a group of four violin concerti by Italian composer Antonio Vivaldi, each of which gives a musical expression to a season of the year. They were written about 1723 and were published in 1725 in Amsterdam, together with eight additional violin concerti, as Il cimento dell'armonia e dell'inventione ("The Contest Between Harmony and Invention").
The Four Seasons is the best known of Vivaldi's works. Unusually for the time, Vivaldi published the concerti with accompanying poems (possibly written by Vivaldi himself) that elucidated what it was about those seasons that his music was intended to evoke. It provides one of the earliest and most-detailed examples of what was later called program music—music with a narrative element.
Vivaldi took great pains to relate his music to the texts of the poems, translating the poetic lines themselves directly into the music on the page. In the middle section of the Spring concerto, where the goatherd sleeps, his barking dog can be marked in the viola section. Other natural occurrences are similarly evoked. Vivaldi separated each concerto into three movements, fast-slow-fast, and likewise each linked sonnet into three sections. His arrangement is as follows:
Gift (The Autumns EP)
Gift is an EP by the American alternative rock band The Autumns, released in a limited edition of 150 in 2003. The EP was given away at a fundraising concert put on by the band to help raise the money needed to mix their self-titled third album .
Track listing
Gift (Maaya Sakamoto song)
"Gift" is the third single from singer Maaya Sakamoto. It was released in Japan on September 22, 1997. "Gift" was used as the second ending song for Clamp School Detectives anime.
Track listing
References
Multiple sclerosis research
Treatments under investigation for multiple sclerosis may improve function, curtail attacks, or limit the progression of the underlying disease. Many treatments already in clinical trials involve drugs that are used in other diseases or medications that have not been designed specifically for multiple sclerosis. There are also trials involving the combination of drugs that are already in use for multiple sclerosis. Finally, there are also many basic investigations that try to understand better the disease and in the future may help to find new treatments.
Research directions
Research directions on MS treatments include investigations of MS pathogenesis and heterogeneity; research of more effective, convenient, or tolerable new treatments for RRMS; creation of therapies for the progressive subtypes; neuroprotection strategies; and the search for effective symptomatic treatments.
Advancements during the last decades have led to the recent approval of several oral drugs. These drugs are expected to gain in popularity and frequency of use at the expense of previously existing therapies. Further oral drugs are still under investigation, the most notable example being laquinimod, which was announced in August 2012 to be the focus of a third phase III trial after mixed results in the previous ones. Similarly, several other studies are aimed to improve efficacy and ease of use of already existing therapies through the use of novel preparations. Such is the case the PEGylated version of interferon-β-1a, that has a longer life than normal interferon and therefore it is being studied if given at less frequent doses has a similar efficacy than the existing product. Request for approval of peginterferon beta-1a is expected during 2013.
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